The expression and function of CD133 in cancer cells
Project/Area Number |
19790240
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Pathological medical chemistry
|
Research Institution | Kinki University |
Principal Investigator |
ARAO Tokuzo Kinki University, 医学部, 講師 (20441074)
|
Research Collaborator |
NISHIO Kazuto 近畿大学, 医学部, 教授 (10208134)
|
Project Period (FY) |
2007 – 2008
|
Project Status |
Completed (Fiscal Year 2008)
|
Budget Amount *help |
¥3,230,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,800,000 (Direct Cost: ¥1,800,000)
|
Keywords | CD133 / がん幹細胞 / 分子腫瘍学 / mTORシグナル / HIF-1A / 消化器癌 / 幹細胞 / マイクロアレイ |
Research Abstract |
がん細胞の幹細胞マーカーCD133の発現は、mTORシグナル阻害により発現が誘導され、低酸素およびHIF-1A誘導剤により発現が著明に抑制されることを見出した.本研究によりCD133発現制御メカニズムは、HIF-1Aを介して抑制的に制御されていることを初めて明らかにした.この研究はがん幹細胞の発生初期のシグナル伝達およびがん幹細胞機能維持の原因解明につながる手がかりになると考えられる.
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Report
(3 results)
Research Products
(61 results)
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[Journal Article] Circulating endothelial cells in non-small cell lung cancer patients treated with carboplatin and paclitaxel2009
Author(s)
Kawaishi M, Fujiwara Y, Fukui T, Kato T, Yamada K, Ohe Y, Kunitoh H, Sekine I, Yamamoto N, Nokihara H, Watabe T, Shimoda Y, Arao T, Nishio K, Tamura T, Koizumi F
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Journal Title
J Thorac Oncol 4(2)
Pages: 208-13
Related Report
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[Journal Article] Identification of Predictive Biomarkers for Response to Trastuzumab Using Plasma FUCA Activity and N-Glycan Identified by MALDI-TOF-MS2009
Author(s)
Matsumoto K, Shimizu C, Arao T, Andoh M, Katsumata N, Kohno T, Yonemori K, Koizumi F, Yokote H, Aogi K, Tamura K, Nishio K, Fujiwara Y
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Journal Title
J Proteome Res 8(2)
Pages: 457-462
Related Report
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[Journal Article] Identification of prognostic biomarkers in gastric cancer using endoscopic biopsy samples2008
Author(s)
Yamada Y, Arao T, Gotoda T, Taniguchi H, Oda I, Shirao K, Shimada Y, Hamaguchi T, Kato K, Hamano T, Koizumi F, Tamura T, Saito D, Shimoda T, Saka M, Fukagawa T, Katai H, Sano T, Sasako M, Nishio K
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Journal Title
Cancer Sci 99(11)
Pages: 2193-9
NAID
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[Journal Article] Aberrant expression of Fra-2 promotes CCR4 expression and cell proliferation in adult T-cell leukemia2008
Author(s)
Nakayama T, Hieshima K, Arao T, Jin Z, Nagakubo D, Shirakawa AK, Yamada Y, Fujii M, Oiso N, Kawada A, Nishio K, Yoshie O
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Journal Title
Oncogene 27(23)
Pages: 3221-32
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