Analysis of amplification and overexpression of EGFR, Her2/neu in malignant pleural mesothelioma

Research Project

Project/Area Number	19790250
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Human pathology
Research Institution	Chiba University
Principal Investigator	YONEMORI Yoko Chiba University, 大学院・医学研究院, 助教 (10422247)
Project Period (FY)	2007 – 2008
Project Status	Completed (Fiscal Year 2008)
Budget Amount *help	¥3,390,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥390,000) Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
Keywords	呼吸器 / 胸膜悪性中皮腫 / FISH / HER2 / neu / EGFR
Research Abstract	Overexpression of the EGFR proteins and ErbB-2 proteins were examined by immunohistochemistry in seventeen malignant pleural mesothelioma. Overexpression of ErbB-2 was found in 11.7% of tumors and was not associated with gene amplification. Overexpression of EGFR was found in 5.8% of tumors and was not associated with gene amplification.