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Epigenetic regulation of TTF-1and its differentiation-inducing properties

Research Project

Project/Area Number 19790257
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Human pathology
Research InstitutionUniversity of Yamanashi

Principal Investigator

KONDO Tetsuo  University of Yamanashi, 大学院・医学工学総合研究部, 講師 (30334858)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,680,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,600,000 (Direct Cost: ¥1,600,000)
Keywords甲状腺癌 / 遺伝子 / エピジェネティックス
Research Abstract

In the thyroid, Thyroid transcription factor-1 (TTF-1) is essential for thyroid organogenesis and governs thyroid functions by regulating various thyroid-specific genes. However, certain subtypes of thyroid cancers have shown low or negative expression of TTF-1. The aim of our study was to investigate the function of epigenetic modification in dysregulation of TTF-1 in thyroid carcinoma cells. Our data showed that epigenetics is involved with inactivation of TTF-1 in thyroid carcinomas, and provide a possible means of using TTF-1 as a target for differentiation-inducing therapy through epigenetic modification.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (11 results)

All 2009 2008 2007

All Journal Article (7 results) (of which Peer Reviewed: 4 results) Presentation (4 results)

  • [Journal Article] Epigenetic silencing of TTF-1/NKX2-1 through DNA hypermethylation and histone H3 modulation in thyroid carcinomas.2009

    • Author(s)
      Kondo T, Nakazawa T, Ma D, et, al.
    • Journal Title

      Lab Invest 89(7)

      Pages: 791-799

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic silencing of TTF-1/NKX2-1 through DNA hypermethylation and histone H3 modulation in thyroid carcinomas.2009

    • Author(s)
      Kondo T, et al
    • Journal Title

      Laboratory Investigation 89(7)

      Pages: 791-799

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic dysregulation in thyroid neoplasia2008

    • Author(s)
      Kondo T, Asa SL, Ezzat S.
    • Journal Title

      Endocrinol Metab Clin North 37(2)

      Pages: 389-400

    • Related Report
      2009 Final Research Report
  • [Journal Article] Epigenetic dysregulation in thyroid neoplasia2008

    • Author(s)
      Kondo T, et.al.
    • Journal Title

      Endocrinol Metab Clin North Am 37

      Pages: 389-400

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Enhanced B-Raf protein expression is independent of V600E mutant status in thyroid carcinomas.2007

    • Author(s)
      Kondo T, et. al.
    • Journal Title

      Human Pathology 38

      Pages: 1810-1818

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The canser/testis antigen melanoma-associated antigen A3/A6 is a novel target of fibroblast growth factor receptor 2-IIIb through histone H3 modifications in thyroid cancer.2007

    • Author(s)
      Kondo T, et. al.
    • Journal Title

      Clinical Cancer Research 13

      Pages: 4713-4720

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetically controlled fibroblast growth factor receptor 2 signaling imposes on the RAS/BRAF/mitogen-activated protein kinase pathway to modulate thyroid cancer progression.2007

    • Author(s)
      Kondo T, et. al.
    • Journal Title

      Cancer Research 67

      Pages: 5461-5470

    • Related Report
      2007 Annual Research Report
  • [Presentation] 転写因子TTF-1のエピジェネティックス制御に関する検討2009

    • Author(s)
      近藤哲夫, 他
    • Organizer
      第13回日本内分泌病理学会
    • Place of Presentation
      甲府
    • Year and Date
      2009-10-25
    • Related Report
      2009 Final Research Report
  • [Presentation] Epigenetically Silencing of TTF-1/NKX2-1 through DNA Hyper-Methylation and Histone H3 Modulation in Thyroid Carcinomas2009

    • Author(s)
      Kondo T, et al
    • Organizer
      ENDO(北米内分泌学会)
    • Place of Presentation
      Washington DC、USA
    • Year and Date
      2009-07-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] 甲状腺癌におけるthyroid transcription factor-1のエピジェネティックス機構を介した遺伝子発現制御2009

    • Author(s)
      近藤哲夫, 他
    • Organizer
      第98回日本病理学会
    • Place of Presentation
      京都
    • Year and Date
      2009-05-02
    • Related Report
      2009 Final Research Report
  • [Presentation] 甲状腺癌におけるB-Raf蛋白発現に関する検討2007

    • Author(s)
      近藤哲夫, 他
    • Organizer
      日本内分泌病理学会
    • Place of Presentation
      札幌
    • Year and Date
      2007-10-19
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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