Analysis for significance of HER2 oncogene amplification and genomic instability in breast cancer from atomic bomb survivors
Project/Area Number |
19790263
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Human pathology
|
Research Institution | Nagasaki University |
Principal Investigator |
MEIRMANOV Serik Nagasaki University, 大学院・医歯薬学総合研究科, 助教 (20423642)
|
Project Period (FY) |
2007 – 2008
|
Project Status |
Completed (Fiscal Year 2008)
|
Budget Amount *help |
¥3,620,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥1,800,000 (Direct Cost: ¥1,800,000)
|
Keywords | 放射線 / 乳癌 / 被爆者 / 遺伝子増幅 / ゲノム不安定性 / ゲノム不安性 / がん遺伝子 |
Research Abstract |
被爆者には乳癌リスクの上昇に加え、HER-2とC-MYCがん遺伝子増幅が高頻度であることが判明した。様々な腫瘍でがん遺伝子増幅が知られていてゲノム不安定性が関与している。放射線は線量依存性にDNA二重鎖切断を引き起こし、切断されたDNAは修復機構により再結合するが、修復メカニズムはエラーも起こす。そのため遺伝子の再配列や増幅が生じると考えられる。
|
Report
(3 results)
Research Products
(17 results)
-
-
[Journal Article] Foci formation of P53-binding protein 1 in thyroid tumors : activation of genomic instability during thyroid carcinogenesis2008
Author(s)
Nakashima M, Suzuki K, Meirmanov S, Naruke Y, Matsuu-Matsuyama M, Shichijo K, Saenko V, Kondo H, Hayashi T, Ito M, Yamashita S, Sekine I.
-
Journal Title
Int J Cancer 122
Pages: 1082-1088
Related Report
Peer Reviewed
-
-
-
-
-
-
[Journal Article] Clinical implications of pre-operative rapid BRAF analysis for papillary thyroid cancer.2007
Author(s)
Kumagai A, Namba H, Akanov Z, Saenko VA, Meirmanov S, Ohtsuru A, Yano H, Maeda S, Anami M, Hayashi T, Ito M, Sagandikova S, Eleubaeva Z, Mussinov D, Espenbetova M, Yamashita S
-
Journal Title
Endocr J 54
Pages: 399-405
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-