Expression of RANKL in renal cell carcinoma and its association with bone metastasis

• Project/Area Number: 19790268
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Human pathology
• Research Institution: Keio University
• Principal Investigator: MIKAMI Shuji Keio University, 医学部, 助教 (20338180)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,780,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
• Keywords: 腎細胞癌 / 骨転移 / RANKL / RANK / OPG / 破骨細胞

Research Abstract

腎細胞癌96例におけるRANKL,RANK,OPG発現を検討した結果、RANKL,RANK高発現・OPG低発現例が高頻度に骨転移をきたすことが判明した。さらに腎細胞癌由来細胞株Caki-1にRANKL蛋白を添加して培養するとmigrationが亢進した。この作用はOPGを添加することで抑制された。RANKL,RANK高発現・OPG低発現例は骨のみでなく他臓器に転移しやすいこともわかったので、RANKL,RANK,OPGsystemはmigrationを制御することにより骨および他臓器への転移にかかわっていると考えられる。

Research Products

• [Journal Article] Increased RANKL expression is related to tumor migration and metastasis of renal cell carcinomas. (2009)
  • Author(s): Mikami S, Katsube K, Oya M,Ishida M, Kosaka T, Mochizuki S, Ikeda T, Mukai M, Okada Y.
  • Journal Title: Journal of Pathology (in press)
  • Peer Reviewed
• [Journal Article] Increased RANKL expression is related to tumor migration and metastasis of renal cell carcinomas (2009)
  • Author(s): Mikami S, Katsube K, Oya M, Ishida M, Kosaka T, Mochizuki S, Ikeda T, Mukai M, Okada Y
  • Journal Title: Journal of Pathology (in press)
  • Peer Reviewed
• [Presentation] RANKL EXPRESSION IN CLEAR CELL RENAL CELL CARCINOMAS AND ITS ASSOCIATION WITH BONE METASTASIS AND CANCER CELL MIGRATION (2008)
  • Author(s): Mikami S, Katsube K, Oya M, Mochizuki M, Shimoda M, Mizuno R, Ishida M, Ikeda T, Mukai M and Okada Y
  • Organizer: American Urological Association 2008 Annual Meeting
  • Place of Presentation: Orland, Florida, USA
  • Year and Date: 2008-05-18