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Expression of RANKL in renal cell carcinoma and its association with bone metastasis

Research Project

Project/Area Number 19790268
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Human pathology
Research InstitutionKeio University

Principal Investigator

MIKAMI Shuji  Keio University, 医学部, 助教 (20338180)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,780,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
Keywords腎細胞癌 / 骨転移 / RANKL / RANK / OPG / 破骨細胞
Research Abstract

腎細胞癌96例におけるRANKL,RANK,OPG発現を検討した結果、RANKL,RANK高発現・OPG低発現例が高頻度に骨転移をきたすことが判明した。さらに腎細胞癌由来細胞株Caki-1にRANKL蛋白を添加して培養するとmigrationが亢進した。この作用はOPGを添加することで抑制された。RANKL,RANK高発現・OPG低発現例は骨のみでなく他臓器に転移しやすいこともわかったので、RANKL,RANK,OPGsystemはmigrationを制御することにより骨および他臓器への転移にかかわっていると考えられる。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (3 results)

All 2009 2008

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (1 results)

  • [Journal Article] Increased RANKL expression is related to tumor migration and metastasis of renal cell carcinomas.2009

    • Author(s)
      Mikami S, Katsube K, Oya M,Ishida M, Kosaka T, Mochizuki S, Ikeda T, Mukai M, Okada Y.
    • Journal Title

      Journal of Pathology (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased RANKL expression is related to tumor migration and metastasis of renal cell carcinomas2009

    • Author(s)
      Mikami S, Katsube K, Oya M, Ishida M, Kosaka T, Mochizuki S, Ikeda T, Mukai M, Okada Y
    • Journal Title

      Journal of Pathology (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] RANKL EXPRESSION IN CLEAR CELL RENAL CELL CARCINOMAS AND ITS ASSOCIATION WITH BONE METASTASIS AND CANCER CELL MIGRATION2008

    • Author(s)
      Mikami S, Katsube K, Oya M, Mochizuki M, Shimoda M, Mizuno R, Ishida M, Ikeda T, Mukai M and Okada Y
    • Organizer
      American Urological Association 2008 Annual Meeting
    • Place of Presentation
      Orland, Florida, USA
    • Year and Date
      2008-05-18
    • Related Report
      2008 Annual Research Report 2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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