Analysis of IGFBP-4/-2expression deficiency in association with cancer progression

• Project/Area Number: 19790272
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Human pathology
• Research Institution: St.Marianna University School of Medicine
• Principal Investigator: SATO Hanako St.Marianna University School of Medicine, 医学部, 助教 (60438132)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,660,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2007: ¥2,100,000 (Direct Cost: ¥2,100,000)
• Keywords: IGFBP-4 / IGFBP-2 / promoter / Hypermethylation / 癌 / Hypermethvlation / Promoter

Research Abstract

正常細胞では増殖抑制因子IGFBP-4/-2を介したフィードバック機構が活性化することにより過剰な増殖が抑制されている。本研究では、癌化・悪性化に伴ってIGFBP-4/-2遺伝子発現制御領域にメチル化が起こることによりIGFBP-4/-2発現が減弱することを多種の癌細胞を用いて明らかにした。この事実はエピジェネティックな要因による癌細胞増殖抑制機構の破綻が普遍的に惹起されていることを示唆している。

Research Products

• [Journal Article] Small Cell Lung Cancer : Significance of RB Alteration and TTF-1 Expression in its Carcinogenesis (2009)
  • Author(s): Kitamura H, Yazawa T, Sato H, Okudela K, Shimoyamada H
  • Journal Title: Phenotype and Biology. Endocrine Pathology (in press)
  • Peer Reviewed
• [Journal Article] Small Cell Lung Cancer: Significance of RB Alterations and TTF-1 Expression in its Carcinogenesis, Phenotype and Biology (2009)
  • Author(s): Kitamura H, et.al.
  • Journal Title: Endocrine Pathology (in press)
  • Peer Reviewed
• [Journal Article] Molecular and Genetitc Pathogenesis of lung Cancer : Differences Between Small-Cell and Non-Small-Cell Carcinomas (2008)
  • Author(s): Kitamura H, Yazawa T, Okudela K, Shimoyamada H, Sato H
  • Journal Title: The Open Pathology Journal 2 Pages: 106-114
  • Peer Reviewed
• [Journal Article] Sex determination using mastoid process measurements : standards for Jamanese human skeletons of the medieval and early modern periods (2008)
  • Author(s): Nagaoka T, Shizushima A, Sawada J, Tomo S, Hoshino K, Sato H, Hirata K
  • Journal Title: Anthropological Science 116 Pages: 105-113
  • Peer Reviewed
• [Journal Article] Molecular and genetic pathogenesis of lung cancer : differences between small-cell and non-small-cell carcinomas (2008)
  • Author(s): Kitamura H, et.al.
  • Journal Title: The Open Pathology Journal1 2 Pages: 106-114
  • Peer Reviewed
• [Journal Article] Sex determination using mastoid process measurements : standards for Jamanese human skeletons of the medieval and early modern periods (2008)
  • Author(s): Nagaoka T, et.al.
  • Journal Title: Anthropological Science 116 Pages: 105-113
  • Peer Reviewed
• [Presentation] 肺癌細胞におけるThyroid Transcription Factor-1(TTF-1)発現とTTF-l promoterのメチレーションとの関連 (2008)
  • Author(s): 佐藤華子、矢澤卓也、下山田博明、奥寺康司、宮田千恵、後藤和哉、石井順、榮田昌史、鈴木瞳、菅間博、北村均
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 金沢
  • Year and Date: 2008-05-17
• [Presentation] 肺癌細胞におけるThyroid Transcription Factor-1(TTF-1)発現とTTF-1 promoterのメチレーションとの関連 (2008)
  • Author(s): 佐藤華子、他4名
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 金沢
  • Year and Date: 2008-05-17
• [Presentation] 肺小細胞癌におけるIGFBP-2過剰発現メカニズムの解析および腫瘍マーカーとしての有用性に関する基礎的検討 (2008)
  • Author(s): 矢澤卓也、佐藤華子、下山田博明、奥寺康司、宮田千恵、石井順、後藤和哉、榮田昌史、北村均
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 金沢
  • Year and Date: 2008-05-15
• [Presentation] Growth regulation viainsulin-like growth factor binding protein-4 and -2 in lung epithelialcells and cancers (2007)
  • Author(s): Sato H, Yazawa T, Shimoyamada H, Okudela K, Kitamura H
  • Organizer: 12th World Conference on Lung Cancer
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2007-09-04
• [Presentation] Effects of vascular endothelial growth factors(VEGFs) on biological behavior of intrathoracic lung cancer cells (2007)
  • Author(s): Shimoyamada H, Yazawa T, Sato H, Okudela K, Kitamura H
  • Organizer: 12th World Conference on Lung Cancer
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2007-09-04
• [Presentation] Growth Regulation via Insulin-like Growth Factor Binding Protein-4 and -2 in lung epithelial cells and cancers. (2007)
  • Author(s): Sato H, et al.
  • Organizer: 12th World Conference on Lung Cancer
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2007-09-04
• [Book] 肺癌-基礎・臨床研究のアップデートー (2008)
  • Author(s): 北村均、矢澤卓也、下山田博明、奥寺康司、佐藤華子
  • Publisher: 日本臨休社
• [Book] 肺癌-基礎・臨床研究のアップデート- (2008)
  • Author(s): 北村均、他4名
  • Publisher: 日本臨牀社