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Study of the mechanism on cancer-stroma interaction at the invasive front of colorectal cancer

Research Project

Project/Area Number 19790275
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Human pathology
Research InstitutionNational Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East

Principal Investigator

FUKASAWA Yuri  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East, 病理部, 研究員 (90392331)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,560,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥2,000,000 (Direct Cost: ¥2,000,000)
Keywords消化器 / がん / 病理学 / 癌
Research Abstract

大腸がんの浸潤先進部において、がん細胞周囲に存在する間質組織に注目し、圧排性発育を呈するがん間質と、浸潤性発育を呈するがん間質の発現を比較した。浸潤性発育を呈する腫瘍の周囲において発現の高かった候補遺伝子のうち、CXCL12(ケモカインのリガンドの一種)においてヒト大腸がん症例165例を用いた免疫組織化学染色を施行した。浸潤性発育を呈する腫瘍部分に高頻度にCXCL12の発現を認め、CXCL12高発現群は有意な差をもって予後不良であることがわかった。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (3 results)

All 2009 2008

All Journal Article (1 results) Presentation (2 results)

  • [Journal Article] Prognostic significance of CXCL12 expression in patients with colorectal carcinoma2009

    • Author(s)
      Yuri Akishima-Fukasawa, Yukihiro Nakanishi, Yoshinori Ino, Yoshihiro Moriya, Yae Kanai, Setsuo Hirohashi
    • Journal Title

      AJCP August in press

    • Related Report
      2008 Final Research Report
  • [Presentation] 大腸癌におけるCXCL12/SDF-1の発現の意義2008

    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      石川県立音楽堂(金沢市)
    • Year and Date
      2008-05-15
    • Related Report
      2008 Final Research Report
  • [Presentation] 大腸癌におけるCXCL12/SDF-1の発現の意義2008

    • Author(s)
      深澤 由里
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢
    • Year and Date
      2008-05-15
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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