Dynamism of immature myeloid cells in tumor-bearing host and its regulation by chemokines
Project/Area Number |
19790283
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Experimental pathology
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Research Institution | The University of Tokyo |
Principal Investigator |
UEHA Satoshi The University of Tokyo, 大学院医学系研究科, 特任助教 (00447385)
|
Project Period (FY) |
2007 – 2008
|
Project Status |
Completed (Fiscal Year 2008)
|
Budget Amount *help |
¥3,570,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥2,400,000 (Direct Cost: ¥2,400,000)
|
Keywords | 腫瘍 / 細胞遊走 / ケモカイン / 樹状細胞 / マクロファージ / 好中球 / 癌 / MDSC / TAM |
Research Abstract |
マウス皮下腫瘍モデルを用いて、担癌宿主における免疫抑制に重要な役割を果たすとされるImCが主にマクロファージと好中球から構成されており、これらの細胞の担癌宿主内動態がケモカイン受容体CCR2 によって制御されている事を明らかにした。
|
Report
(3 results)
Research Products
(18 results)
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[Journal Article] Chemokine-mediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing mice.2008
Author(s)
Sawanobori Y, Ueha S, Kurachi M, Shimaoka T, Talmadge JE, Abe J, Shono Y, Kitabatake M, Kakimi K, Mukaida N, Matsushima K.
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Journal Title
Blood 111(12)
Pages: 5457-66
Related Report
Peer Reviewed
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