Dynamism of immature myeloid cells in tumor-bearing host and its regulation by chemokines

• Project/Area Number: 19790283
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Experimental pathology
• Research Institution: The University of Tokyo
• Principal Investigator: UEHA Satoshi The University of Tokyo, 大学院医学系研究科, 特任助教 (00447385)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,570,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2007: ¥2,400,000 (Direct Cost: ¥2,400,000)
• Keywords: 腫瘍 / 細胞遊走 / ケモカイン / 樹状細胞 / マクロファージ / 好中球 / 癌 / MDSC / TAM

Research Abstract

マウス皮下腫瘍モデルを用いて、担癌宿主における免疫抑制に重要な役割を果たすとされるImCが主にマクロファージと好中球から構成されており、これらの細胞の担癌宿主内動態がケモカイン受容体CCR2 によって制御されている事を明らかにした。

Research Products

• [Journal Article] Chemokine-mediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing mice. (2008)
  • Author(s): Sawanobori Y, Ueha S, Kurachi M, Shimaoka T, Talmadge JE, Abe J, Shono Y, Kitabatake M, Kakimi K, Mukaida N, Matsushima K.
  • Journal Title: Blood 111(12) Pages: 5457-66
  • Peer Reviewed
• [Journal Article] Chemokine-mediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing mice (2008)
  • Author(s): Ueha S
  • Journal Title: Blood (印刷中)
  • Peer Reviewed
• [Presentation] Chemokine-mediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing mice (2008)
  • Author(s): 上羽悟史
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都市左京区・国立京都国際会館
  • Year and Date: 2008-12-02
• [Presentation] Chemokine-mediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing mice (2008)
  • Author(s): 上羽悟史
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋市熱田区・名古屋国際会議場
  • Year and Date: 2008-10-28
• [Presentation] ケモカインによるCD11b+Gr-1+ "Myeloid-derived suppressor cells"の単眼宿主内動態制御 (2008)
  • Author(s): 上羽悟史
  • Organizer: 第29回日本炎症・再生学会
  • Place of Presentation: 東京都千代田区・都市センターホテル
  • Year and Date: 2008-07-09
• [Presentation] ケモカインによるCD11b+Gr-1+"Myeloid derived suppressor cells"の単眼宿主内動態制御 (2008)
  • Author(s): 上羽悟史
  • Organizer: 第29回日本炎症・再生学会
  • Place of Presentation: 東京都千代田区・都市センターホテル
  • Year and Date: 2008-07-09
• [Presentation] Chemokine-mediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing mice (2008)
  • Author(s): 上羽悟史
  • Organizer: 第12回基盤的癌免疫研究会
  • Place of Presentation: さいたま市大宮区・大宮ソニックシティ
  • Year and Date: 2008-07-03
• [Presentation] Chemokine-mediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing mice (2008)
  • Author(s): 上羽悟史
  • Organizer: 第17回日本癌病態治療研究会
  • Place of Presentation: 京都市下京区・メルパルク京都
  • Year and Date: 2008-06-27
• [Presentation] Pivotal role of CCR2 in the recruitment of CD11b+Gr-1dull immature myeloid cells to the tumor tissue (2007)
  • Author(s): Yasushi Sawanobori
  • Organizer: 第37回日本免疫学会総会・学術集会
  • Place of Presentation: 港区グランドプリンスホテル新高輪
  • Year and Date: 2007-11-22
• [Presentation] Pivotal role of CCR2 in the recruitment of CD11b+Gr-1dull immature myeloid cells to the tumor tissue (2007)
  • Author(s): Yasushi Sawanobori
  • Organizer: 第37回 日本免疫学会総会・学術集会
  • Place of Presentation: 駿河区静岡コンベンションアーツセンター
  • Year and Date: 2007-11-22
• [Presentation] Pivotal role of CCR2 in the recruitment of CD11b+Gr-1dull immature myeloid cells to the tumor tissue (2007)
  • Author(s): Satoshi Ueha
  • Organizer: 66th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: 横浜市パシフィコ横浜
  • Year and Date: 2007-10-03
• [Presentation] Pivotal role of CCR2 in the recruitment of CD11b+Gr-1dull immature myeloid cells to the tumor tissue (2007)
  • Author(s): Satoshi Ueha
  • Organizer: 66th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: 横浜市 パシフィコ横浜
  • Year and Date: 2007-10-03
• [Presentation] CCR2による未成熟ミエロイド系細胞の腫瘍浸潤制御 (2007)
  • Author(s): 上羽悟史
  • Organizer: 第28回日本炎症・再生医学会
  • Place of Presentation: 新宿区京王プラザホテル
  • Year and Date: 2007-08-02
• [Presentation] CCR2による未成熟ミエロイド系細胞の腫瘍浸潤制御 (2007)
  • Author(s): 上羽 悟史
  • Organizer: 第28回日本炎症・再生医学会
  • Place of Presentation: 新宿区 京王プラザホテル
  • Year and Date: 2007-08-02
• [Presentation] Pivotal role of CCR2 in the recruitment of CD11b+Gr-1dull immature myeloid cells to the tumor tissue (2007)
  • Author(s): Satoshi Ueha
  • Organizer: 第11回基盤的癌免疫研究会総会
  • Place of Presentation: 文京区東京大学鉄門記念講堂
  • Year and Date: 2007-07-11
• [Presentation] Pivotal role of CCR2 in the recruitment of CD11b+Gr-1dull immature myeloid cells to the tumor tissue (2007)
  • Author(s): Satoshi Ueha
  • Organizer: 第11回基盤的癌免疫研究会総会
  • Place of Presentation: 文京区 東京大学鉄門記念講堂
  • Year and Date: 2007-07-11
• [Presentation] Pivotal role of CCR2 in the recruitment of CD11b+Gr-1dull immature myeloid cells to the tumor tissue (2007)
  • Author(s): Satoshi Ueha
  • Organizer: International symposium on molecular cell biology of macrophages
  • Place of Presentation: 駿河区静岡コンベンションアーツセンター
  • Year and Date: 2007-06-15
• [Book] ケモカインによる制御性T 細胞と骨髄系抑制性細胞の担癌宿主内動態制御 (2009)
  • Author(s): 上羽悟史, 松島綱治
  • Publisher: Minophargen Medical Review