CXCL14 and tissue macrophages in gastrointestinal tumorigenesis

• Project/Area Number: 19790285
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Experimental pathology
• Research Institution: Kanazawa University
• Principal Investigator: OSHIMA Hiroko Kanazawa University, がん研究所, 助教 (80362515)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥570,000); Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,300,000)
• Keywords: 胃がん / 腸管腫瘍 / マクロファージ / CXCL14 / ケモカイン / 炎症 / 胃癌

Research Abstract

消化器がんの発生過程では胃や大腸の粘膜上皮細胞が腫瘍化することとともに、腫瘍細胞周囲にマクロファージが浸潤して活性化することが重要であると考えられていた。本研究では、腸管腫瘍発生マウスモデルでマクロファージを欠損させると腫瘍発生が抑制されることを明らかにした。さらに、マクロファージ浸潤に関与すると考えられたケモカインCXCL14の遺伝子ノックアウトマウスを作製して解析した結果、CXCL14は腫瘍組織へのマクロファージ浸潤に関与していない可能性が示された。

Research Products

• [Journal Article] Induction of prostaglandin E2 pathway promotes gastric hamartoma development with suppression of bone morphogenetic protein signaling. (2009)
  • Author(s): Oshima H, Itadani H, Kotani H, 他1名
  • Journal Title: Cancer Res 69 Pages: 2729-2733
  • NAID: 120001413737
  • Peer Reviewed
• [Journal Article] Induction of prostaglandin E2 pathway promotes gastric hamartoma development with suppression of bone morphogenetic protein signaling (2009)
  • Author(s): Oshima H, et.al.
  • Journal Title: Cancer Research 69(in press)
  • NAID: 120001413737
  • Peer Reviewed
• [Journal Article] The interleukin-6 family cytokine interleukin-11 regulates homeostatic epithelial cell turnover and promotes gastric tumor development. (2008)
  • Author(s): Howlett M, Giraud A, Lescesen H, 他11名
  • Journal Title: Gastroenterology 136 Pages: 967-977
  • Peer Reviewed
• [Journal Article] Activated macrophages promote Wnt signaling through tumor necrosis factor-α in gastric tumor cell. (2008)
  • Author(s): Oguma K, Oshima H, Aoki M, 他7名
  • Journal Title: EMBO J 27 Pages: 1671-1681
  • Peer Reviewed
• [Journal Article] Stromal fiboblasts activated by tumor cells promote angiogenesis in mouse gastric cancer. (2008)
  • Author(s): Guo X, Oshima H, Kitamura T, 他2名
  • Journal Title: J Biol Chem 283 Pages: 19864-19871
  • Peer Reviewed
• [Journal Article] Platelet 12-lipoxigenase accelerates tumor promotion of mouse epidermal cells through enhancement of cloning efficiency. (2008)
  • Author(s): Piao YS, Du YC, Oshima H, 他4名
  • Journal Title: Carcinogenesis 29 Pages: 440-447
  • Peer Reviewed
• [Journal Article] Activated macrophages promote Wnt signaling through tumor necrosis factor-a in gastric tumor cells (2008)
  • Author(s): Oguma K, Oshima H, et.al.
  • Journal Title: EMBO Journal 27 Pages: 1671-1381
  • Peer Reviewed
• [Journal Article] Stromal fibroblasts activated by tumor cells promote angiogenesis in mouse gastric cancer (2008)
  • Author(s): Guo X, Oshima H, et.al.
  • Journal Title: Journal of Biological Chemistry 283 Pages: 19864-19871
  • Peer Reviewed
• [Journal Article] Increased level of serum vascular endothelial growth factor by long-term exposure to hypergravity. (2007)
  • Author(s): Oshima M, Suzuki H, Guo X, Oshima H.
  • Journal Title: Exp Anim 56 Pages: 309-313
  • NAID: 130000068034
  • Peer Reviewed
• [Journal Article] Increased level of serum vascular endothelial growth factor by long-term exposure to hypergravity (2007)
  • Author(s): Oshima M., et. al.
  • Journal Title: Experimental Animals 56 Pages: 309-313
  • NAID: 130000068034
  • Peer Reviewed
• [Journal Article] Platelet 12-1ipoxigenase accelerates tumor promotion of mouse epidermal cells through enhancement of cloning efficiency (2007)
  • Author(s): Piao Y., et. al.
  • Journal Title: Carcinogenesis 29 Pages: 440-447
  • Peer Reviewed
• [Presentation] Gastric tumorigenesis through EGFR activation in Wnt and PGE2 transgenic mice. (2008)
  • Author(s): Oshima H, Oguma K, Kotani H, 他1名
  • Organizer: 67th Annual Meeting for Japanese Cancer Association 日本癌学会学術総会
  • Place of Presentation: Nagoya
  • Year and Date: 2008-10-28
• [Presentation] Gastric tumorigenesis through EGFR activation in Wnt and PGE2 transgenic mice (2008)
  • Author(s): Oshima H, et.al.
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-28
• [Presentation] Gastric carcinogenesis : Lessons from mouse models of gastric cancer. (2008)
  • Author(s): Oshima H, Oshma M.
  • Organizer: 2nd Asan International Digestive Disease Symposium
  • Place of Presentation: Seoul
  • Year and Date: 2008-07-05
• [Presentation] Inflammatory responses accelerate Wnt signaling in gastric epithelial cells. (2008)
  • Author(s): Oshima M, Oshima H, Oguma K, 他2名
  • Organizer: 99th Annual Meeting of American Association for Cancer Research (AACR)
  • Place of Presentation: San Diego
  • Year and Date: 2008-04-15
• [Presentation] Novel gastric cancer mouse model by transgenic expression of Wnt1 and PGE_2 (2008)
  • Author(s): Oshima H.
  • Organizer: International symposium on tumor biology in Kanazawa
  • Place of Presentation: Kanazawa
  • Year and Date: 2008-01-24
• [Presentation] Promotion of Wnt signaling by activated macrophage-derived TNF-α. (2008)
  • Author(s): Oguma K, Oshima H, Aoki M, 他7名
  • Organizer: 67th Annual Meeting for Japanese Cancer Association 日本癌学会学術総会
  • Place of Presentation: Nagoya
• [Presentation] Novel gastric cancer mouse model by transgenic expression of Wnt1 and prostaglandin E_2 (2007)
  • Author(s): Oshima H, Taketo MM, Oshima M.
  • Organizer: 12th Korea-Japan Cancer Research Workshop
  • Place of Presentation: Sapporo
  • Year and Date: 2007-12-22
• [Presentation] 皮膚表皮JB6P+細胞の形質転換における12-リポキシゲナーゼの促進作用 (2007)
  • Author(s): 朴英実, 杜宇?, 大島浩子, 他4名
  • Organizer: 第30回日本分子生物学会第80回日本生化学会合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-14
• [Presentation] 活性化マクロファージによるWntシグナルの亢進 (2007)
  • Author(s): 小熊圭祐, 大島浩子, 仲一仁, 他2名
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-04
• [Presentation] WntシグナルとPGE_2経路の活性化による胃がん発生モデルマウス (2007)
  • Author(s): 大島正伸, 大島浩子, 武藤誠
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-04
• [Presentation] Mouse model of gastric cancer by simultaneous activation of Wnt and PGE_2 pathways. (2007)
  • Author(s): Oshima M, Oshima H and Taketo MM.
  • Organizer: Annual Meeting of American Association for Cancer Research (AACR)
  • Place of Presentation: Los Angeles
  • Year and Date: 2007-04-18
• [Presentation] Mouse model of gastric cancer by simultaneous activation of Wnt and PGE_2 pathways (2007)
  • Author(s): Oshima M, Oshima H, et. al.
  • Organizer: Annual Meeting of American Association for Cancer Research (AACR)
  • Place of Presentation: 米国ロサンゼルス
  • Year and Date: 2007-04-18
• [Book] Prostaglandin and transforming growth factor-β signaling in gastric cancer. In The Biology of Gastric Cancers(Eds. by Wang TC. et al.) (2008)
  • Author(s): Oshima M, Oshima H, Taketo MM.
  • Publisher: Springer
• [Book] "Prostaglandin and transforming growth factor β signaling in gastric cancer" in The Biology of Gastric Cancer (2008)
  • Author(s): Oshima M, Oshima H, et.al.
  • Total Pages: 28
  • Publisher: SpringeSpringer(New York)