Functional analysis of ADAMTS-13 on atherothrombosis
| Project/Area Number |
19790293
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental pathology
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| Research Institution | University of Miyazaki |
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Principal Investigator |
YAMASHITA Atsushi University of Miyazaki, 医学部・病理学講座, 助教 (90372797)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥3,710,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥510,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | 疾患モデル動物 / ADAMTS13 / フォンウィルブランド因子 / 動脈血栓 |
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| Research Abstract |
血栓形成に重要な血液因子であるフォンウィルブランド因子の分解酵素ADAMTS-13が動脈硬化性血栓に局在すること、動脈硬化性血栓の形成に抑制性に機能していることを明らかにした。
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Report
(3 results)
Research Products
(43 results)
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[Journal Article] Ultrasound accelerates thrombolysis of acutely induced platelet-rich thrombi similar to those in acute myocardial infarction2007
Author(s)
Kawata H, Naya N, Takemoto Y, Uemura S, Nakajima T, Horii M, Takeda Y, Fujimoto S, Yamashita A, Asada Y, Saito Y
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Thrombin generation by intimal tissue factor contributes to thrombus formation on macrophage-rich neointima but not normal intima of hyperlipidemic rabbits
Author(s)
Yamashita A, Matsuda S, Matsumoto T, Moriguchi-Goto S, Takahashi M, Sugita C, Sumi T, Imamura T, Shima M, Kitamura K, Asada Y
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Journal Title
Atherosclerosis (in press)
Related Report
Peer Reviewed
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