Functional analysis of ADAMTS-13 on atherothrombosis

• Project/Area Number: 19790293
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Experimental pathology
• Research Institution: University of Miyazaki
• Principal Investigator: YAMASHITA Atsushi University of Miyazaki, 医学部・病理学講座, 助教 (90372797)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,710,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥510,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2007: ¥1,500,000 (Direct Cost: ¥1,500,000)
• Keywords: 疾患モデル動物 / ADAMTS13 / フォンウィルブランド因子 / 動脈血栓

Research Abstract

血栓形成に重要な血液因子であるフォンウィルブランド因子の分解酵素ADAMTS-13が動脈硬化性血栓に局在すること、動脈硬化性血栓の形成に抑制性に機能していることを明らかにした。

Research Products

• [Journal Article] Interleukin-10 correlates with oxidized low density lipoprotein in coronary culprit plaques (2009)
  • Author(s): Nishihira, K
  • Journal Title: Thromb Res (In press)
  • Peer Reviewed
• [Journal Article] Critical Role of von Willebrand Factor and Platelet Interaction in VenousThromboembolism (2009)
  • Author(s): Takahashi, M
  • Journal Title: Histol Histophathol (In press)
  • Peer Reviewed
• [Journal Article] Thrombin generation by intimal tissue factor contributes to thrombus format macrophage-rich neointima but not normal intima of hyperlipidemic rabbits (2009)
  • Author(s): Yamashita, A
  • Journal Title: Atherosclerosis (In press)
  • Peer Reviewed
• [Journal Article] Serotonin induces vasoconstriction of smooth muscle cell-rich neointima through 5-hydroxytryptamine2A receptor in rabbit femoral arteries (2008)
  • Author(s): Yamashita A, Nishihira K, Tanaka N, Moriguchi-Goto S, Imamura T, Ishida T, Kawashima S, Yamamoto R, Kitamura K, Asada Y
  • Journal Title: J Thromb Haemost 6 Pages: 1207-14
  • Peer Reviewed
• [Journal Article] Both 5-hydroxytryptamine 5-HT2A and 5-HT1B receptors are involved in the vasoconstrictor response to 5-HT in the human isolated internal thoracic artery (2008)
  • Author(s): Tanaka N, Nakamura E, Ohkura M, Kuwabara M, Yamashita A, Onitsuka T, Asada Y, Hisa H, Yamamoto R
  • Journal Title: Clin Exp Pharmacol Physiol 35 Pages: 836-40
  • Peer Reviewed
• [Journal Article] Thioredoxin in coronary culprit lesions: possible relationship to oxidative stress and intraplaque hemorrhage (2008)
  • Author(s): Nishihira K, Yamashita A, Imamura T, Hatakeyama K, Sato Y, Nakamura H, Yodoi J, Ogawa H, Kitamura K, Asada Y
  • Journal Title: Atherosclerosis 201 Pages: 360-7
  • Peer Reviewed
• [Journal Article] Medial and adventitial macrophages are associated with expansive atherosclerotic remodeling in rabbit femoral artery (2008)
  • Author(s): Yamashita A, Shoji K, Tsuruda T, Furukoji E, Takahashi M, Nishihira K, Tamura S, Asada Y
  • Journal Title: Histol Histopathol 23 Pages: 127-36
  • Peer Reviewed
• [Journal Article] Ecto-nucleoside triphosphate diphosphohydrolase inhibits ATP- and ADP-induced vasoconstriction (2008)
  • Author(s): Furukoji E, Tanaka N, Yamashita A, Matsumoto M, Fujimura Y, Yamamoto R, Tamura S, Asada Y
  • Journal Title: Thromb Res 121 Pages: 583-5
  • Peer Reviewed
• [Journal Article] ADANITS-13 attenuates thrombus formation on type I collagen surface and disrupted plaques under flow conditions (2008)
  • Author(s): origuchi-Goto, S
  • Journal Title: I Atherosclerosis (In press)
  • Peer Reviewed
• [Journal Article] Thioredoxin in coronary culprit lesions : possible relationship to oxidative stress and intraplaque hemorrhage (2008)
  • Author(s): Nishihira, K
  • Journal Title: Atherosclerosis 201 Pages: 360-367
  • Peer Reviewed
• [Journal Article] Both 5-hydroxytryptamine 5-HT2A and 5-HT1B receptors are involved in the vasoconstrictor response to 5-HT in the human isolated internal thoracic artery (2008)
  • Author(s): Tanaka, N
  • Journal Title: Clin Exp Pharmacol Physiol 35 Pages: 836-840
  • Peer Reviewed
• [Journal Article] Serotonin induces vasoconstriction of smooth muscle cell-rich neointima through 5-hydroxytryptamine2A receptor in rabbit femoral arteries (2008)
  • Author(s): Yamashita, A
  • Journal Title: J Thromb Haemost 6 Pages: 1207-1214
  • Peer Reviewed
• [Journal Article] Ecto-nucleoside triphosphate diphosphohydrolase inhibits ATP-and ADP-induced vasoconstriction. (2008)
  • Author(s): Furukoji, E
  • Journal Title: Thromb Res 121 Pages: 583-585
  • Peer Reviewed
• [Journal Article] Medial and adventitial macrophages are associated with expansive atherosclerotic remodeling in rabbit femoral artery (2008)
  • Author(s): Yamashita, A
  • Journal Title: Histol Histopathol 23 Pages: 127-136
  • Peer Reviewed
• [Journal Article] Thioredoxin in Coronary Culprit Lesions: Possible Relationship to Oxidative Stress and Intraplaque Hemorrhage. (2008)
  • Author(s): Nishihira, K
  • Journal Title: Atherosclerosis (In press)
  • Peer Reviewed
• [Journal Article] Serotonin induces vasoconstriction of smooth muscle cell-rich neointima through 5-hydroxytryptamine_<2A>receptor in rabbit femoral arteries. (2008)
  • Author(s): Yamashita, A
  • Journal Title: J Thromb Haemost (In press)
  • Peer Reviewed
• [Journal Article] Both 5-hydroxytryptamine 5-HT(2A)and 5-HT(1B)receptors are involved in the vasoconstrictor response to 5-HT in the human isolated internal thoracic artery. (2008)
  • Author(s): Tanaka, N
  • Journal Title: Clin Exp Pharmacol Physiol (In press)
  • Peer Reviewed
• [Journal Article] Ultrasound accelerates thrombolysis of acutely induced platelet-rich thrombi similar to those in acute myocardial infarction (2007)
  • Author(s): Kawata H, Naya N, Takemoto Y, Uemura S, Nakajima T, Horii M, Takeda Y, Fujimoto S, Yamashita A, Asada Y, Saito Y
  • Journal Title: Circ J 71 Pages: 1643-8
  • Peer Reviewed
• [Journal Article] Expression of interleukin-18 in coronary plaque obtained by atherectomy from patients with stable and unstable angina (2007)
  • Author(s): Nishihira K, Imamura T, Hatakeyama K, Yamashita A, Shibata Y, Date H, Manabe I, Nagai R, Kitamura K, Asada Y
  • Journal Title: Thromb Res 121 Pages: 275-9
  • Peer Reviewed
• [Journal Article] Expression of interleukin-18 in coronary plaque obtained by atherectomy from patients with stable and unstable angina. (2007)
  • Author(s): Nishihira, K
  • Journal Title: Thromb Res 121 Pages: 275-279
  • Peer Reviewed
• [Journal Article] Ultrasound accelerates thrombolysis of acutely induced platelet-rich thrombi similar to those in acute myocardial infarction. (2007)
  • Author(s): Kawata, H
  • Journal Title: Cir J 71 Pages: 1643-1648
  • Peer Reviewed
• [Journal Article] ADAMTS-13 attenuates thrombus formation on type I collagen surface and disrupted plaques under flow conditions
  • Author(s): Moriguchi-Goto S, Yamashita A, Tamura N, Soejima K, Takahashi M, Nakagaki T, Goto S, Asada Y
  • Journal Title: Atherosclerosis (in press)
• [Journal Article] Thrombin generation by intimal tissue factor contributes to thrombus formation on macrophage-rich neointima but not normal intima of hyperlipidemic rabbits
  • Author(s): Yamashita A, Matsuda S, Matsumoto T, Moriguchi-Goto S, Takahashi M, Sugita C, Sumi T, Imamura T, Shima M, Kitamura K, Asada Y
  • Journal Title: Atherosclerosis (in press)
  • Peer Reviewed
• [Journal Article] Crucial Role of von Willebrand Factor and Platelet Interaction in Venous Thromboembolism
  • Author(s): Takahashi M, Yamashita A, Moriguchi-Goto S, Marutsuka K, Sato Y, Yamamoto H, Koshimoto C, Asada Y
  • Journal Title: Histol Histopathol (in press)
  • Peer Reviewed
• [Journal Article] Interleukin-10 correlates with oxidized low density lipoprotein in coronary culprit plaques
  • Author(s): Nishihira K, Imamura T, Ishikawa T, Yamashita A, Shibata Y, Itabe H, Kitamura K, Asada Y
  • Journal Title: Thromb Res (in press)
  • Peer Reviewed
• [Presentation] 5-HTによる平滑筋細胞に富む動脈硬化巣の収縮:血栓性血管収縮における肥厚内膜の関与 (2008)
  • Author(s): 山下篤
  • Organizer: 第31回日本血栓止血学会
  • Place of Presentation: 大阪
• [Presentation] 血液凝固XI因子は深部静脈血栓に存在しトロンビン産生を介して血栓の成長に関与する (2008)
  • Author(s): 高橋良咲
  • Organizer: 第31回日本血栓止血学会
  • Place of Presentation: 大阪
• [Presentation] ヒト深部静脈血栓における血液凝固VIII因子の局在と機能 (2008)
  • Author(s): 杉田千泰
  • Organizer: 第31回日本血栓止血学会
  • Place of Presentation: 大阪
• [Presentation] 高脂血症下における動脈血栓の形成機序-動脈硬化巣と健常動脈での差異 (2008)
  • Author(s): 山下篤
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 金沢
• [Presentation] 5-HTによる平滑筋細胞に富む動脈硬化巣の収縮 : 血栓性血管収縮における肥厚内膜の関与 (2008)
  • Author(s): 山下篤
  • Organizer: 第31回日本血栓止血学会
  • Place of Presentation: 大阪
• [Presentation] 動脈硬化性血栓と健常動脈血栓の違い (2007)
  • Author(s): 山下篤
  • Organizer: 第30回日本血栓止血学会
  • Place of Presentation: 志摩市
• [Presentation] 動脈血栓におけるADAMTS13の局在と機能 (2007)
  • Author(s): 山下篤
  • Organizer: 第18回九州血管血栓フォーラム
  • Place of Presentation: 大分市
• [Presentation] ADAMTS-13 within hrombus down-regulates thrombus formation under flow conditions (2007)
  • Author(s): Moriguchi-Goto S
  • Organizer: XXIst Congress of the International Society on Thrombosis and Haemostasis
  • Place of Presentation: Jeneva
• [Presentation] Mechanisms of thrombus formation differ between atherosclerotic and normal arteries in hypercholesterolemic rabbits (2007)
  • Author(s): Yamashita A
  • Organizer: XXIst Congress of the International Society on Thrombosis and Haemostasis
  • Place of Presentation: Jeneva
• [Presentation] Platelet is an important factor in venous thromboembolism : Interaction of von Willebrand factor and platelet GPIb promotes venous thrombus growth (2007)
  • Author(s): Takahashi M
  • Organizer: XXIst Congress of the International Society on Thrombosis and Haemostasis
  • Place of Presentation: Jeneva
• [Presentation] Functional regulation of von Willebrand factor on the formation of platelet thrombi under blood flow condition by its specific cleaving protease of ADAMTS13 (2007)
  • Author(s): Tamura N
  • Organizer: XXIst Congress of the International Society on Thrombosis and Haemostasis
  • Place of Presentation: Jeneva
• [Presentation] ADAMTS-13 within thrombus down-regulates thrombus formation under flow conditions. (2007)
  • Author(s): Moriguchi-Goto, S
  • Organizer: XXIst Congress of the International Society on Thrombosis and Haemostasis
  • Place of Presentation: Jeneva
• [Presentation] Mechanisms of thrombus formation differ between atherosclerotic and normal arteries in hypercholesterolemic rabbits. (2007)
  • Author(s): Yamashita, A
  • Organizer: XXIst Congress of the International Society on Thrombosis and Haemostasis
  • Place of Presentation: Jeneva
• [Presentation] Platelet is an important factor in venous thromboembolism: Interaction of von Willebrand factor and platelet GPIb promotes venous thrombus growth. (2007)
  • Author(s): Takahashi, M
  • Organizer: XXIst Congress of the International Society on Thrombosis and Haemostasis
  • Place of Presentation: Jeneva
• [Presentation] Functional regulation of von Willebrand factor on the formation of platelet thrombi under blood flow condition by its specific cleaving protease of ADAMTS13. (2007)
  • Author(s): Tamura, N
  • Organizer: XXIst Congress of the International Society on Thrombosis and Haemostasis
  • Place of Presentation: Jeneva
• [Book] Recent Advances in Thrombosis and Hemostasis 2008 (2008)
  • Author(s): Tanaka, K and Davie EW
  • Publisher: Springer
• [Book] 血栓症・動脈硬化モデル動物作成法 (2007)
  • Author(s): 鈴木宏治、金芳堂
• [Book] 血栓症・動脈硬化モデル動物作成法 (2007)
  • Author(s): 鈴木宏治
  • Publisher: 金芳堂