Localization of erythrocyte invasion ligand defines virulence of Malaria parasites

• Project/Area Number: 19790308
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Parasitology (including Sanitary zoology)
• Research Institution: Ehime University
• Principal Investigator: OTSUKI Hitoshi Ehime University, 大学院・医学系研究科, 助教 (80403806)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,780,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
• Keywords: マラリア / 病原性 / 侵入 / 遺伝子組換え / マラリア原虫 / 赤血球侵入 / 遺伝子導入

Research Abstract

マラリア原虫の赤血球侵入分子EBLは原虫の赤血球侵入にとって必須なリガンド分子であり、かつ重要なワクチン候補分子でもある。本研究により、EBL分子の機能不明なシステインに富んだ領域6が、細胞内輸送におけるマイクロネームへの輸送を決定する部位である事、ネズミマラリア原虫Plasmodium yoelii17X株と17XL株の赤血球への感染性の違いは、領域6のアミノ酸置換を原因とするEBL分子の異なった細胞内小器官への局在が原因である事が明らかとなった。

Research Products

• [Journal Article] Single amino acid substitution in Plasmodium yoelii erythrocyte ligand determines its localization and controls parasite virulence (2009)
  • Author(s): 大槻均、金子修、Amporn Thongkukiatkul、橘真由美、入子英幸、竹尾暁、坪井敬文、鳥居本美
  • Journal Title: Proceedings of the National Academy of Sciences of the United States of America vol.106 no.17 Pages: 7167-7172
  • NAID: 120006984096
  • Peer Reviewed
• [Journal Article] Single amino acid substitution in Plasmodium yoelii erythrocyte ligand determines its localization and controls parasite virulence (2009)
  • Author(s): 大槻均、金子修、Amporn Thongkugiatkul、橘真由美、入子英幸、竹尾暁, 坪井敬文、鳥居本美
  • Journal Title: Proceedings of the National Academy of Sciences of the United States of America 電子版 Pages: 1-6
  • NAID: 120006984096
  • Peer Reviewed
• [Presentation] Erythrocyte-Binding-Like molecule and Virulence of Plasmodium yoelii 43rd Annual (2009)
  • Author(s): 大槻均、金子修、Amporn Thongkukiatkul、橘真由美、入子英幸、竹尾暁、坪井敬文、鳥居本美
  • Organizer: U.S.-Japan Joint Conference on Parasitic Diseases
  • Place of Presentation: 東京
  • Year and Date: 2009-01-07
• [Presentation] ErythrocyteBinding-Like molecule and Virulence of Plasmodium yoelii (2009)
  • Author(s): 大槻均、金子修、Ampom Thongku kiatkul、橘真由美、入子英幸、竹尾暁、坪井敬文、鳥居本美
  • Organizer: 43rd Annual U.S.-Japan Joint Conference on Parasitic Diseases
  • Place of Presentation: 東京
  • Year and Date: 2009-01-07
• [Presentation] Erythrocyte-Binding-Like molecule and Virulence of Plasmodium yoelii (2008)
  • Author(s): 大槻均、金子修、Amporn Thongkukiatkul、橘真由美、入子英幸、竹尾暁、坪井敬文、鳥居本美
  • Organizer: Molecular Parasitology Meeting
  • Place of Presentation: 米国
  • Year and Date: 2008-09-21
• [Presentation] Erythrocyte-Binding-Like molecule and Virulence of Plasmodium yoelii Molecular Parasitology Meeting (2008)
  • Author(s): 大槻均、金子修、Ampom Thongku kiatkul、橘真由美、入子英幸、竹尾暁、坪井敬文、鳥居本美
  • Organizer: Molecular Parasitology Meeting
  • Place of Presentation: 米国マサチューセッチュ州ウッズホール
  • Year and Date: 2008-09-21
• [Presentation] ネズミマラリア原虫の赤血球結合分子EBLの局在と病原性 (2008)
  • Author(s): 大槻均、金子修、Amporn Thongkukiatkul、橘真由美、入子英幸、竹尾暁、坪井敬文、鳥居本美
  • Organizer: 日本寄生虫学会大会
  • Place of Presentation: 長崎市
  • Year and Date: 2008-04-03
• [Presentation] ネズミマラリア原虫の赤血球結合分子EBLの局在と病原生 (2008)
  • Author(s): 大槻均、金子修、Ampom Thongku kiatkul、橘真由美、入子英幸、竹尾暁、坪井敬文、鳥居本美
  • Organizer: 日本寄生虫学会大会
  • Place of Presentation: 長崎市
  • Year and Date: 2008-04-03