| Budget Amount *help |
¥3,800,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥600,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Research Abstract |
Caspase-8 is one of the key factors for controlling both cell death and innate immune response in macrophage. In this study, we suggest that Salmonella can induce caspase-8 activation dependently on translocation of novel effectors, GogA and GtgA by SPI1 in macrophage cell. Whereas caspase-8 activation induced by the normal level of GogA and GtgA is involved in the induction of cytokine production, that induced by higher level of those is involved in the induction of apoptosis. Taking these findings together, it is suggested that Salmonella controls the induction of caspase-8 activity thorough regulation of GogA and GtgA expression.
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