The relationship between Salmonella-induced macrophage cell death and innate immune response
| Project/Area Number |
19790313
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Chiba University |
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Principal Investigator |
TAKAYA Akiko Chiba University, 大学院・薬学研究院, 准教授 (80334217)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,800,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥600,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | サルモネラ / マクロファージ / エフェクター / SPI1 / カスパーゼ-8 / NF-κB / 病原性 / NF-kB活性化 / SPI2 / サイトカイン / アポトーシス / カスパーゼー8 |
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| Research Abstract |
Caspase-8 is one of the key factors for controlling both cell death and innate immune response in macrophage. In this study, we suggest that Salmonella can induce caspase-8 activation dependently on translocation of novel effectors, GogA and GtgA by SPI1 in macrophage cell. Whereas caspase-8 activation induced by the normal level of GogA and GtgA is involved in the induction of cytokine production, that induced by higher level of those is involved in the induction of apoptosis. Taking these findings together, it is suggested that Salmonella controls the induction of caspase-8 activity thorough regulation of GogA and GtgA expression.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Expressed Salmonella antigens within macrophages enhance the proliferation of CD4+ and CD8+ T lymphocytes by means of bystander dendritic cells.2007
Author(s)
Eguchi, M., Sekiya, Y., Kikuchi, Y., Takaya, A., Yamamoto, T., Matsui, H.
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Journal Title
FEMS Immunol Med Microbiol. Vol.50
Pages: 411-420
Related Report
Peer Reviewed
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[Journal Article] Expressed Salmonella antigens within macrophages enhance the proliferation of CD4+ and CD8+ T lymphocytes by means of bystander dendritic cells.2007
Author(s)
Eguchi, M., Sekiya, Y., Kikuchi, Y., Takaya, A., Yamamoto, T., and Matsui, H
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Journal Title
FEMS Immunol Med Microbiol. 50
Pages: 411-420
Related Report
Peer Reviewed
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[Presentation] A novel effector, which is involved in the caspase-8 activation within Salmonella-infected macrophage cells.2009
Author(s)
Takaya, A., Kobayashi, S., Tsuzuku, N., Yamamoto, T.
Organizer
3rd ASM Conference on Salmonella.
Place of Presentation
Centre de Congres, Aix-en-Provence, France
Year and Date
2009-10-08
Related Report
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