Analysis of the tumor metastasis inhibited by Citrobacter rodentium infection and the investigation of bacterial anti-metastasis vaccine.
Project/Area Number |
19790317
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Bacteriology (including Mycology)
|
Research Institution | Keio University (2008) The University of Tokyo (2007) |
Principal Investigator |
NAGAI Takeshi Keio University, 医学部, 助教 (60418655)
|
Project Period (FY) |
2007 – 2008
|
Project Status |
Completed (Fiscal Year 2008)
|
Budget Amount *help |
¥3,780,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
|
Keywords | 細菌 / 感染症 / 癌 / 癌転移 / 細菌感染 |
Research Abstract |
マウスに大腸炎を誘導するCitrobacter rodentiumと癌転移の相関関係について研究を行った。一度C. rodentiumに感染したマウスでは、その後の黒色腫細胞移入による肺への癌転移が有意に抑制された。この抑制作用は、C. rodentiumに対する何らかの抗体が、癌細胞の表面抗原に交差反応をして見られる現象であることを明らかにした。
|
Report
(3 results)
Research Products
(6 results)
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[Journal Article] Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses2009
Author(s)
Ishigame H, Kakuta S, Nagai T, Kadoki M, Nambu A, Komiyama Y, Fujikado N, Tanahashi Y, Akitsu A, Kotaki H, Sudo K, Nakae S, Sasakawa C, Iwakura Y
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Journal Title
Immunity 30
Pages: 108-116
Related Report
Peer Reviewed
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[Journal Article] The enteropathogenic E. coli-effector EspB facilitates microvilli effacing and antiphagocytosis by inhibiting myosin function2007
Author(s)
Iizumi, Y., Sagara H, Kabe Y, Azuma M, Kume K, Ogawa M, Nagai T, Gillespie PG, Sasakawa C, Handa H
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Journal Title
Cell Host Microbe 2
Pages: 383-392
Related Report
Peer Reviewed
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[Journal Article] Helicobacter pylori Dampens Gut Epithelial Self-Renewal by Inhibiting Apoptosis, a Bacterial Strategy to Enhance Colonization of the Stomach2007
Author(s)
Mimuro H, Suzuki T, Nagai S, Rieder G, Suzuki M, Nagai T, Fujita Y, Nagamatsu K, Ishijima N, Koyasu S, Haas R, Sasakawa C
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Journal Title
Cell Hostand and Microbe 4
Pages: 255-263
Related Report
Peer Reviewed
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