Regulation of virulence gene coordinately expressed with the type 3 protein secretion system in enterohemorrhagic Escherichia coli
| Project/Area Number |
19790330
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
IYODA Sunao National Institute of Infectious Diseases, 細菌第一部, 主任研究官 (70300928)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥3,720,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | 腸管出血性大腸菌 / 遺伝子発現制御 / 3型蛋白質輸送装置 / LEE |
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| Research Abstract |
腸管出血性大腸菌が保有する病原性遺伝子群LEEの転写発現は、LEEにコードされるLerとGrlAによって正に制御されている。GrlAはLEEの発現活性化因子である一方、べん毛遺伝子群の転写発現を負に制御し、エンテロヘモリシンの転写発現は正に制御する因子であることが明らかとなった。GrlAはLEEと他の病原性遺伝子群の発現を協調的に制御するグローバルレギュレータとして機能していることが示唆された。
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] Molecular characterization of enterohemorrhagic Escherichia coli O157:H7 isolates dispersed across Japan by pulsed-field gel electrophoresis and multiple-locus variable-number tandem repeat analysis.2008
Author(s)
Pei Y, Terajima J, Saito Y, Suzuki R, Takai N, Izumiya H, Morita-Ishihara T, Ohnishi M, Miura M, Iyoda S, Mitobe J, Wang B, Watanabe H.
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Journal Title
Jpn J Infect Dis 61
Pages: 58-64
Related Report
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[Journal Article] Complete genome sequence and comparative analysis of the wild-type commensal Escherichia coli strain SE11 isolated from a healthy adult.2008
Author(s)
Oshima K, Toh H, Ogura Y, Sasamoto H, Morita H, Park SH, Ooka T, Iyoda S, Taylor TD, Hayashi T, Itoh K, Hattori M.
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Journal Title
DNA Res 15
Pages: 375-386
Related Report
Peer Reviewed
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