Molecular analysis of virus-induced chemokine production in brain glial cells.

Research Project

Project/Area Number	19790349
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Virology
Research Institution	National Institute of Infectious Diseases
Principal Investigator	NAKAMICHI Kazuo National Institute of Infectious Diseases, ウイルス第一部, 主任研究官 (50348190)
Project Period (FY)	2007 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥3,800,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥600,000) Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2007: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywords	ウイルス / 脳 / 神経 / 脳神経疾患 / 免疫学 / グリア / ケモカイン
Research Abstract	During virus infection, brain glial cells act as a source of chemokines, which facilitate the recruitment peripheral leukocytes into the central nervous system and orchestrate immune response against the infectious agent. In this study, spatial and temporal patterns of chemokine production were examined in the brains of virus-infected mouse. The results indicate that virus infection induces the expression of specific chemokines in the mouse brain.