The development of type-1 tumor immunotherapy based on removing immunosupression from tumor-bearer

• Project/Area Number: 19790351
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Immunology
• Research Institution: Hokkaido University
• Principal Investigator: CHAMOTO Kenji Hokkaido University, 遺伝子病制御研究所, 助教 (50447041)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,690,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥2,000,000 (Direct Cost: ¥2,000,000)
• Keywords: サイトカイン / 腫瘍免疫 / 腫瘍免疫学 / 免疫学 / 細胞生物学

Research Abstract

現在、第4のがん治療法としてがんに対する免疫治療法に期待がよせられている。最終目標は担癌生体内に癌特異的なキラーT 細胞 (CTL)を出現させることであるが、現在の免疫治療法にはまだまだ改善の余地がある。そのためにはA)タイプ1型免疫を十分に活性化させること、B)担癌生体内における免疫抑制機構を解明し、克服することが必要である。そこで本研究ではA)タイプ1型治療と放射線治療の併用治療法の開発B)担癌生体内における免疫抑制機構の解明と新規免疫治療の開発を行った。

Research Products

• [Journal Article] Combination immunotherapy with radiation and CpG-based tumor vaccination for the eradication of radio- and immuno-resistant lung carcinoma cells. (2009)
  • Author(s): Chamoto K,Takeshima T, Wakita D, Ohkuri T, Ashino S, Omatsu T, Shirato, H, Kitamura H, Nishimura T.
  • Journal Title: Cancer Science 100(5) Pages: 394-9
  • NAID: 10025145915
  • Peer Reviewed
• [Journal Article] Potential differentiation of tumor bearing mouse CD11b+ Gr-1+ immature myeloid cells into both supressor macrophage and immunostimmulatory dendritic cells (2009)
  • Author(s): Narita Y and Chamoto K, et.al.
  • Journal Title: Biomedical Research 30 Pages: 7-15
  • Peer Reviewed
• [Journal Article] Sialyl lewisx antigen-expressing human CD4+T and CD8+T cells as initial immune responders in memory phenotype subsets (2009)
  • Author(s): Zhang Y and Chamoto K, et.al.
  • Journal Title: J Leukoc Biol. 84 Pages: 730-735
  • Peer Reviewed
• [Journal Article] 免疫バランス制御の新しいパラダイム:Th1 主導免疫によるがんエスケープ機構の克服 (2008)
  • Author(s): 茶本健司、脇田大功、西村孝司
  • Journal Title: 先端医学社 分子細胞治療 7(3) Pages: 171-180
• [Journal Article] Indispensable role of IL-6-dependent spontaneous proliferation in inducing colitogenic IL-17-producing CD8^+T cells. (2008)
  • Author(s): Tajima M., Chamoto K., et. al.
  • Journal Title: Journal of Experimental Medicine (In press)
  • Peer Reviewed
• [Journal Article] Anti-OX40 monoclonal antibody therapy in combination with radiotherapy results in therapeutic antitumor immunity to murine lung cancer. (2008)
  • Author(s): Yokouchi H., Chamoto K., et. al.
  • Journal Title: Cancer Science 99 Pages: 361-7
  • NAID: 10024002650
  • Peer Reviewed
• [Journal Article] CpG-ODN inhibits airway inflammation at effector phase through down-regulation of antigen-specific Th2-cell migration into lung. (2008)
  • Author(s): Ashino S., Chamoto K, et. al.
  • Journal Title: International Immunology 20 Pages: 259-66
  • Peer Reviewed
• [Journal Article] Combination tumor immunotherapy with radiotherapy and Th1 cell therapy against murine lung carcinoma. (2007)
  • Author(s): Yokouchi H, Chamoto K (第一著者と同等に貢献), Wakita D, Yamazaki K, Shirato H, Takeshima T, Dosaka-Akita H, Nishimura M, Yue Z, Kitamura H, Nishimura T.
  • Journal Title: Clinical & Experimental Metastasis. 24 Pages: 533-40
  • Peer Reviewed
• [Journal Article] Combination tumor immunotherapy with radiotherapy and Th1 cell therapy against murine lung carcinoma. (2007)
  • Author(s): Yokouchi H, Chamoto K(第一著者と同等に貢献), et. al.
  • Journal Title: Clinical & Experimental Metastasis 24 Pages: 533-540
  • Peer Reviewed
• [Journal Article] Blocking of IL-6 signaling pathway prevents CD4_+T cell-mediated colitis in a T(h)17-independent manner. Int Immunol. (2007)
  • Author(s): Noguchi D., Chamoto K, et. al.
  • Journal Title: International Immunology 19 Pages: 1431-40
  • Peer Reviewed
• [Journal Article] Th1 cell adjuvant therapy combined with tumor vaccination: a novel strategy for promoting CTL responses while avoiding the accumulation of Tregs. (2007)
  • Author(s): Zhang Y., Chamoto K, et. al.
  • Journal Title: International Immunology 19 Pages: 151-61
  • Peer Reviewed
• [Journal Article] Combination immunotherapy with radiation and CpG-based tumor vaccination for the eradication of radio-and immuno-resistant lung carcinoma cells
  • Author(s): Kenji Chamoto, Takashi Nismura, et.al.
  • Journal Title: Cancer Science (印刷中)
  • NAID: 10025145915
  • Peer Reviewed
• [Journal Article] Identification of novel helper epitopes of MAGE-A4 tumour antigen : useful tool for the propagation of Thl cells
  • Author(s): Ohkuri T and Chamoto K, et.al.
  • Journal Title: Br J Cancer (印刷中)
  • Peer Reviewed
• [Presentation] 癌幹細胞によるTregを介した新規免疫抑制機構の解明 (2008)
  • Author(s): 茶本健司
  • Organizer: 第38回日本免疫学会総会
  • Place of Presentation: 京都、国立京都国際会館
  • Year and Date: 2008-12-02
• [Presentation] A crucial role of cancer stem cell for the regulation of immunosuppressive tumor escape via Treg induction. Treg誘導を介した癌幹細胞の免疫抑制機構の解明 (2008)
  • Author(s): 茶本健司、脇田大功、成田義規、大栗敬幸、打浪雄介、富樫裕二、北村秀光、西村孝司
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2008-10-30
• [Presentation] Treg誘導を介した癌幹細胞の免疫抑制機構の解明 (2008)
  • Author(s): 茶本健司
  • Organizer: 第67回日本癌学学会術総会
  • Place of Presentation: 名古屋、名古屋国際会議場
  • Year and Date: 2008-10-30
• [Presentation] 担癌生体内のTregを介した免疫抑制機構の解明メチルコラントレン誘発性上皮癌と肉腫のTGF-b産生能力の違いとその意義 (2008)
  • Author(s): 茶本健司
  • Organizer: 第12回基盤的癌免疫研究会総会
  • Place of Presentation: 埼玉県大宮ソニックシティ
  • Year and Date: 2008-07-03
• [Presentation] TGF-beta high-producing ability of mouse carcinomas determines their refractoriness against Treg-depletion therapy. (2008)
  • Author(s): Takashi Nishimura., Kenji Chamoto.
  • Organizer: 12th International Conference on Lymphocyte Activati on and Immune Regulation.
  • Place of Presentation: Fairmont Newport Beach Hotel
  • Year and Date: 2008-02-08
• [Presentation] TGF-beta high-producing ability of mouse carcinomas determines their refractoriness against Treg-depletion therapy. (2008)
  • Author(s): Takashi Nishimura, Daiko Wakita, Masaki Tajima and Kenji Chamoto.
  • Organizer: 12th International Conference on Lymphocyte Activation and Immune Regulation.
  • Place of Presentation: California
• [Presentation] A crucial role of cancer stem cell for the regulation of immunosuppressive tumor escape via Treg induction癌幹細胞によるTregを介した新規免疫抑制機構の解明 (2008)
  • Author(s): 茶本健司、脇田大功、打浪雄介、大栗敬幸、西村孝司
  • Organizer: 第38 回日本免疫学会総会・学術集会
  • Place of Presentation: 国立京都国際会館
• [Presentation] 担癌生体内のTregを介した免疫抑制機構の解明 メチルコラントレン誘発性上皮癌と肉腫のTGF-ss産生能力の違いとその意義 (2008)
  • Author(s): 茶本健司、脇田大功、成田義規、富樫裕二、北村秀光、西村孝司
  • Organizer: 第12 回基盤的癌免疫研究会総会抄録
  • Place of Presentation: 埼玉県さいたま市大宮ソニックシティ
• [Presentation] 原発性上皮癌と肉腫におけるTregを介した免疫抑制機構の解明 (2007)
  • Author(s): 茶本健司、脇田大功、成田義規、張悦、北村秀光、西村孝司
  • Organizer: 第37回日本免疫学会総会
  • Place of Presentation: グランドプリンスホテル新高輪
  • Year and Date: 2007-11-22
• [Presentation] CpG癌ワクチンと放射線併用治療による上皮性癌治療法の開発 (2007)
  • Author(s): 茶本健司、脇田大功、武島英嗣、張悦、白土博樹、北村秀光、西村孝司
  • Organizer: 第66回日本癌学会総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-10-05
• [Presentation] CpG癌ワクチンと放射線併用治療による上皮性癌治療法の開発 (2007)
  • Author(s): 茶本健司、脇田大功、武島英嗣、張悦、白土博樹、北村秀光、西村孝司
  • Organizer: 第11回基盤的癌免疫研究会総会
  • Place of Presentation: 東京大学鉄門記念講堂
  • Year and Date: 2007-10-05
• [Presentation] Differential role of Treg-mediated immunosupression between carcinoma- and sarcoma-bearing mice (2007)
  • Author(s): Kenji Chamoto, Daiko Wakita, Yoshinori Narita, Zhang Yue, Hidemitsu Kitamura, Takashi Nishimura
  • Organizer: 第37回日本免疫学会総会・学術集会記録
  • Place of Presentation: 東京グランドプリンスホテル新高輪
• [Presentation] CpG癌ワクチンと放射線併用治療による上皮性癌治療法の開発 (2007)
  • Author(s): 茶本健司、脇田大功、武島英嗣、張悦、白土博樹、北村秀光、西村孝司
  • Organizer: 第66 回日本癌学会総会・学術会記録
  • Place of Presentation: パシフィコ横浜
• [Presentation] CpG癌ワクチンと放射線併用治療による上皮性癌治療法の開発 (2007)
  • Author(s): 茶本健司、脇田大功、武島英嗣、張悦、白土博樹、北村秀光、西村孝司
  • Organizer: 第11 回基盤的癌免疫研究会総会抄録
  • Place of Presentation: 東京大学鉄門記念講堂
• [Book] 免疫バランス制御の新しいパラダイム : Th1主導免疫によるがんエスケープ機構の克服 (2008)
  • Author(s): 茶本健司、脇田大功、西村孝司
  • Total Pages: 7
  • Publisher: 先端医学社
• [Book] 細胞工学 (2008)
  • Author(s): 茶本健司、脇田大功、西村孝司
  • Publisher: 秀潤社
• [Remarks]
  • URL: http://www.igm.hokudai.ac.jp/immreg/
• [Remarks]
  • URL: http://www.igm.hokudai.ac.jp/immreg/
• [Remarks]
  • URL: http://www.igm.hokudai.ac.jp/immreg/