Differentiation and maturation of innate immune cells via TLR

• Project/Area Number: 19790354
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Immunology
• Research Institution: University of Toyama
• Principal Investigator: NAGAI Yoshinori University of Toyama, 大学院医学薬学研究部, 准教授 (30431761)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,690,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥2,000,000 (Direct Cost: ¥2,000,000)
• Keywords: 免疫学 / 自然免疫 / Toll-like receptor / 造血分化

Research Abstract

すべての血液細胞は、骨髄に存在する造血幹細胞、前駆細胞から分化する。その分化は、サイトカインや転写因子などにより、厳密に制御されている。本研究では、未分化な造血前駆細胞に細菌DNAの受容体が発現していることを明らかにした。この受容体を介して、細菌DNAやウイルスを認識することにより、造血前駆細胞からの形質細胞様樹状細胞への分化が誘導されることを明らかにした。

Research Products

• [Journal Article] Interleukin 5 in the link betwe6n the innate and acquired immune response (2009)
  • Author(s): Takatsu, K., et.al.
  • Journal Title: Adv. Immunol 101 Pages: 191-236
  • Peer Reviewed
• [Journal Article] TLRシグナルとクラススイッチ組換え (2008)
  • Author(s): 長井良憲, 塚本裕美子, 高津聖志
  • Journal Title: 臨床免疫・アレルギー科 49(3) Pages: 246-251
• [Journal Article] Lymphoid precursors are directed to produce dendritic cells as a result of TLR9 ligation during herpes infection (2008)
  • Author(s): Welner, R.S., R. Pelayo, Y. Nagai, K.P. Garrett, T.R. Wuest, D.J. Carr, L.A. Borghesi, M.A. Farrar, P.W. Kincade
  • Journal Title: Blood 112(9) Pages: 3753-3761
  • Peer Reviewed
• [Journal Article] Tonic B cell activation by Radioprotective 105/MD-1 promotes disease progression in MRL/lpr mice. Int (2008)
  • Author(s): Kobayashi, T., K. Takahashi, Y. Nagai, T. Shibata, M. Otani, S. Izui, S. Akira, Y. Gotoh, H. Kiyono, K. Miyake.
  • Journal Title: Immunol. 20(7) Pages: 881-891
  • Peer Reviewed
• [Journal Article] Lymphoid precursors are directed to produce dendritic cells as a result of TLR9 ligation during herpes infection (2008)
  • Author(s): Welner, R.S., et.al.
  • Journal Title: Blood 112 Pages: 3753-3761
  • Peer Reviewed
• [Journal Article] 自然免疫系細胞への分化におけるTLRの役割 (2007)
  • Author(s): 長井良憲
  • Journal Title: 臨床免疫・アレルギー科 47(5) Pages: 610-618
  • NAID: 40015525631
• [Journal Article] A protein associated with Toll-like receptor 4 (PRAT4A) is required for TLR-dependent immune responses (2007)
  • Author(s): Takahashi, K., T. Shibata, S. Akashi-Takamura, T. Kiyokawa, Y. Wakabayashi, N. Tanimura, T. Kobayashi, F. Matsumoto, R. Fukui, T. Kouro, Y. Nagai, K. Takatsu, S. S-I. Saitoh, K. Miyake.
  • Journal Title: J. Exp. Med. 204(12) Pages: 2963-2976
  • Peer Reviewed
• [Journal Article] A protein associated with Toll-like receptor (TLR) 4 (PRAT4A) is required for TLR-dependent immune responses (2007)
  • Author(s): Takahashi, K., et. al.
  • Journal Title: Journal of Experimental Medicine 204 Pages: 2963-2976
  • Peer Reviewed
• [Presentation] Identification of soluble MD-1 and its role in autoimmune diseases (2008)
  • Author(s): Sasaki, S., Y. Nagai and K. Takatsu.
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-03
• [Presentation] TLR4/MD-2 and RP105/MD-1 differentially regulate LPS responsiveness in B cells (2008)
  • Author(s): Nagai, Y., M. Ikutani, A. Kariyone, S. Ohta, K. Miyake and K. Takatsu
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-02
• [Presentation] B-1 cell-restricted differentiation of IL-7R+ lymphoid progenitors from fetal liver (2008)
  • Author(s): Kouro, T., M. Ikutani, A. Teratani, Y. Nagai and K. Takatsu
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-02
• [Presentation] PDCA-1 and mouse plasmacytoid DC precursor cells (2008)
  • Author(s): Nakamura, T., Y. Nagai and K. Takatsu.
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-02
• [Presentation] Natural plant products modulate innate immunity via TLRs (2008)
  • Author(s): Honda, H., Y. Nagai, K. Miyake and K. Takatsu.
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-02
• [Presentation] Search for a natural product that regulates innate immunity via TLRs (2008)
  • Author(s): Honda, H., et.al
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-02
• [Presentation] B-1 cell restricted differentiation of IL-7R+ lymphoid progenitors from fetal liver (2008)
  • Author(s): Kouro, T., et.al.
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-02
• [Presentation] Microbial flora-independent signaling via Toll-like receptor 2/4 and RP105 induces IgG3 and predisposes to lupus nephritis (2007)
  • Author(s): Kobayashi, T., K. Takahashi, Y. Nagai, T. Shibata, Y. Gotoh, H. Kiyono, S. Akira and K. Miyake.
  • Organizer: 第37回日本免疫学会総会・学術集会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-22
• [Presentation] Microbial flora-independent signaling via Toll-1ike receptor 2/4 and RP 105 induces serum IgG3 and predisposes to lupus nephritis. (2007)
  • Author(s): Kobayashi, T., et. al.
  • Organizer: 第37回日本免疫学会総会・学術集会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-22
• [Book] インターロイキン、インターロイキン受容体「分子細胞生物学辞典」第2版 (2009)
  • Author(s): 長井良憲, ら
  • Publisher: 東京化学同人
• [Book] 臨床免疫・アレルギー科Vo.49 No.3 TLRシグナルとクラススイッチ組換え (2008)
  • Author(s): 長井 良憲
  • Total Pages: 6
  • Publisher: 科学評論社
• [Book] 免疫総論「免疫とは」臨床アレルギー学(改訂第3版) (2007)
  • Author(s): 長井良憲, 高津聖志
  • Publisher: 南江堂
• [Book] 免疫とは「臨床アレルギー学 アレルギー専門医研修のために」 改訂第3版 (2007)
  • Author(s): 長井 良憲、高津 聖志
  • Total Pages: 3
  • Publisher: 南江堂
• [Book] 臨床免疫・アレルギー科 Vo.47 No.5 自然免疫系細胞への分化におけるTLRの役割 (2007)
  • Author(s): 長井 良憲
  • Total Pages: 9
  • Publisher: 科学評論社