Optimal mycophenolate therapy based on population pharmacokinetic and pharmacodynamic analysis in liver transplant patients

• Project/Area Number: 19790387
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Applied pharmacology
• Research Institution: Kyoto University
• Principal Investigator: FUKUDO Masahide Kyoto University, 医学研究科, 助教 (60437233)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,650,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥450,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
• Keywords: ミコフェノール酸 / 薬物動態 / 薬効 / 相互作用 / 医薬品適正使用 / 肝移植 / 薬物動熊

Research Abstract

本研究課題では、ミコフェノール酸の適正使用を目指して、臨床で使用される薬物との相互作用解析を中心に検討を行った。ラットを用いた実験の結果、ミコフェノール酸とmTOR阻害剤エベロリムスを併用投与した場合、ミコフェノール酸のグルクロン酸抱合代謝物の胆汁中排泄が抑制され、血漿中濃度が上昇することを見出した。本研究成果は、臨床におけるミコフェノール酸の薬物相互作用を理解する上で有用な情報になると考える。

Research Products

• [Journal Article] Prospective evaluation of the Bayesian method for individualizing tacrolimus dose early after living-donor liver transplantation (2009)
  • Author(s): Fukudo, M., Yano, I., Shinsako, K., Katsura, T., Takada, Y., Uemoto, S., Inui, K.
  • Journal Title: J. Clin. Pharmacol. (in press)
  • Peer Reviewed
• [Journal Article] Prospective evaluation of the Bayesian method for individualizing tacrolimus dose early after living-donor liver transplantation (2009)
  • Author(s): Fukudo, M.
  • Journal Title: J Clin Pharmacol
  • Peer Reviewed
• [Journal Article] Impact of MDR1 and CYP3A5 on the oral clearance of tacrolimus and tacrolimus-related renal dysfunction in adult living-donor liver transplant patients (2008)
  • Author(s): Fukudo, M., Yano, I., Yoshimura, A., Masuda, S., Uesugi, M., Hosohata, K., Katsura, T., Ogura, Y., Oike, F., Takada, Y., Uemoto, S., Inui, K.
  • Journal Title: Pharmacogenet. Genomics 18 Pages: 413-423
  • Peer Reviewed
• [Journal Article] Impact of MDR1 and CYP3A5 on the oral clearance of tacrolimus and tacrolimus-related renal dysfunction in adult living-donor liver transplant patients (2008)
  • Author(s): Fukudo, M.
  • Journal Title: Pharmacogenet. Genomics 18 Pages: 413-423
  • Peer Reviewed
• [Presentation] Intestinal CYP3A5 genotype and MDR1 expression influence apparent clearance of tacrolimus in adult living-donor liver transplant recipients (2007)
  • Author(s): Fukudo, M., Yoshimura, A., Yano, I., Masuda, S., Uesugi, M., Hosohata, K., Katsura, T., Takada, Y., Uemoto, S., Inui, K.
  • Organizer: 10^<th> International Congress of Therapeutic Drug Monitoring and Clinical Toxicology (IATDMCT2007)
  • Place of Presentation: Nice, France
• [Presentation] Intestinal CYP3A5 genotype and MDR1 expression influence apparent clearance of tacrolimus in adult living-donor liver transplant recipients (2007)
  • Author(s): 福土 将秀
  • Organizer: 第10回 国際TDM会議
  • Place of Presentation: フランス・ニース市
• [Remarks]
  • URL: http://www.kuhp.kyoto-u.ac.jp/~yakuzai/main.htm