The analysis of the dendritic cells in liver is useful for the condition clarification and the earlier detection of the autoimmune hepatitis.

• Project/Area Number: 19790394
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Laboratory medicine
• Research Institution: Niigata University
• Principal Investigator: TOMIYAMA Chikako Niigata University, 医歯学系, 助教 (80359702)
• Co-Investigator(Renkei-kenkyūsha): WATANABE Hisami 琉球大学熱帯生物圏研究センター, 分子生命科学研究施設・感染免疫制御学分野, 教授 (50143756)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,610,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥510,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2007: ¥1,400,000 (Direct Cost: ¥1,400,000)
• Keywords: 自己免疫性肝炎 / 肝臓 / 樹状細胞 / 調整性T細胞 / 調節性T細胞 / 免疫学 / plasmacytoid DC / IL-10

Research Abstract

We examined whether there was relationship between the proportional change of dendritic cells in the liver of model mouse and the condition of the autoimmune hepatitis. We hypothesized that these results were useful for the clarification of the early diagnostics and underlying mechanism of the autoimmune hepatitis. The plasmacytoid dendritic cells in liver decreased at early stage of liver injury. Activated conventional dendritic cells increased with the liver of the model mouse and produced a large amount of inflammatory cytokines. It explained that the intrahepatic plasmacytoid dendritic cells were necessary to prevention of liver damage. In this situation, the regulatory T cell also increased in liver of the mice. The prevention of the autoimmune hepatitis is necessary for the association between intrahepatic plasmacytoid dendritic cells and regulatory T cells. It was suggested that these findings were useful for the early diagnosis of autoimmune hepatitis and the new method of treatment in the future.

Research Products

• [Presentation] Possible role of hepatic dendrtic cells in preventing liver injury induced by concanavalin A (2008)
  • Author(s): 富山智香子
  • Organizer: 第38回日本免疫学会・学術総会
  • Place of Presentation: 京都
• [Presentation] Possible role of hepatic dendrtic cells in preventing liver injury induced by concanavalin A (2008)
  • Author(s): 富山智香子
  • Organizer: 第38回日本免疫学会総会・学術総会
  • Place of Presentation: 国立京都国際会館(京都)
• [Presentation] Proportional change of liver dendritic cells in concanavalin A-induced hepatitis (2007)
  • Author(s): 富山智香子
  • Organizer: 第37回日本免疫学会・学術総会
  • Place of Presentation: 東京
• [Presentation] Proportional change of liner dendritic cells in concanavalin A-induced hepatitis. (2007)
  • Author(s): 富山・宮路 智香子, 渡部久実, 安保 徹
  • Organizer: 日本免疫学会総会・学術総会
  • Place of Presentation: グランドプリンスホテル新高輪(東京)
• [Remarks]
  • URL: http://www.clg.niigata-u.ac.jp/~tomiyama/tomiHP/toppage.html
• [Remarks]
  • URL: http://www.clg.niigata-u.ac.jp/~tomiyama/tomiHP/toppage.html
• [Remarks]
  • URL: http://www.clg.niigata-u.ac.jp/~tomiyama/tomiHP/toppage.html
• [Remarks]
  • URL: http://www.clg.niigata-u.ac.jp/~tomiyama/tomiHP/toppage.html