Prevalence of plasmid-mediated fluoroquinolone resistance gene harboring Gram-negative bacteria isolated form clinical setting in Japan

• Project/Area Number: 19790400
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Laboratory medicine
• Research Institution: National Institute of Infectious Diseases
• Principal Investigator: YAMANE Kunikazu National Institute of Infectious Diseases, 細菌第二部, 主任研究官 (00356247)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,740,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥540,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥1,400,000 (Direct Cost: ¥1,400,000)
• Keywords: プラスミド / ニューキノロン / 薬剤耐性 / qepA / プラスミド性フルオロキノロン耐性 / 薬剤耐性菌

Research Abstract

Seven hundred fifty-one Escherichia coli clinical isolates collected in National Institute of Infectious Diseases from 140 Japanese hospitals between 2002 and 2006 were screened for the qepA and qnr genes. Two E. coli isolates (0.3%) harbored qepA, but no qnr was identified. The results suggested a low prevalence of E coli harboring qepA or qnr in Japan.

Research Products

• [Journal Article] Plasmid-mediated qepA gene among Escherichia coli clinical isolates from Japan. (2008)
  • Author(s): Yamane K, Wachino J, Suzuki S, Arakawa Y.
  • Journal Title: Antimicrob Agents Chemother 52(4) Pages: 1564-6
• [Journal Article] Plasmid-mediated qepA gene among Eschericbia coli clinical isolates fom Japan (2008)
  • Author(s): Kunikazu Yamane, et. al.
  • Journal Title: Antimicrobial Agents and Chemotherapy 52 Pages: 4564-4566
  • Peer Reviewed
• [Presentation] 日本の臨床現場で分離された大腸菌のプラスミド性フルオロキノロン耐性遺伝子の保有状況 (2008)
  • Author(s): 山根一和
  • Organizer: 第82回日本感染症学会総会
  • Place of Presentation: 松江
  • Year and Date: 2008-04-17
• [Presentation] 大腸菌の多剤耐性プラスミド上に存在するフルオロキノロン特異的薬剤耐性ポンプ(QepA)の解析 (2008)
  • Author(s): 山根 一和
  • Organizer: 第81回日本細菌学会
  • Place of Presentation: 京都
  • Year and Date: 2008-03-25
• [Presentation] 日本の臨床現場で分離された大腸菌のプラスミド性フルオロキノロン耐性遺伝子(qepA,qnr)の保有状況 (2008)
  • Author(s): 山根 一和
  • Organizer: 第19回目本臨床微生物学会
  • Place of Presentation: 東京
  • Year and Date: 2008-01-26
• [Presentation] 日本の臨床現場で分離された大腸菌のプラスミド性フルオロキノロン耐性遺伝子の保有状況 (2008)
  • Author(s): 山根一和、和知野純一、鈴木里和、木村幸司、柴田尚宏、荒川宜親
  • Organizer: 第19回日本臨床微生物学会
• [Presentation] 日本の臨床現場で分離された大腸菌のプラスミド性フルオロキノロン耐性遺伝子の保有状況 (2008)
  • Author(s): 山根一和、鈴木里和、荒川宜親
  • Organizer: 第82回日本感染症学会
• [Presentation] 大腸菌の多剤耐性プラスミド上に存在するフルオロキノロン特異的薬剤排出ポンプ(QepA)の解析 (2008)
  • Author(s): 山根一和、鈴木里和、和知野純一、荒川宜親
  • Organizer: 第81回日本細菌学会
• [Presentation] Plasmid-mediated fluoroquinolone resistance genes,qenA and qnr,amongEscherichia coli clinical isolates in Japan (2007)
  • Author(s): Kunikazu Yamane
  • Organizer: 47th Interscience Conrence on AntimcrobialAgents and Chemotherapy
  • Place of Presentation: アメリカ合衆国シカゴ
  • Year and Date: 2007-09-18
• [Presentation] Plasmid-mediated fluoroquinolone resistance genes, qepA and qnr, among Escherichia coli clinical isolates in Japan. (2007)
  • Author(s): Yamane K, Suzuki K, Wachino J, Arakawa Y.
  • Organizer: 47th Interscience Conference on Antimicrobial Agents and Chemotherapy.