Experimental and epidemiological assessment of the pesticide exposure in general population

• Project/Area Number: 19790404
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Hygiene
• Research Institution: Nagoya University
• Principal Investigator: UEYAMA Jun Nagoya University, 医学部(保健学科), 助教 (00397465)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,610,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2007: ¥2,700,000 (Direct Cost: ¥2,700,000)
• Keywords: 環境中毒 / ピレスロイド系殺虫剤 / 有機リン系殺虫剤 / 一般生活集団 / 殺虫剤散布作業者 / 2型糖尿病 / βグルクロニダーゼ

Research Abstract

DZN の腹腔内投与によってコントロール群の耐糖能にはなんら影響を与えなかったが、II型糖尿病モデル動物の耐糖能は劇的に悪化した。
現在のところ詳細なメカニズムは究明できていないが、DZN がインスリン分泌能を抑制しているわけではないことは明らかとしている。
日本人が日常的に曝露しているピレスロイド系殺虫剤の量は、アメリカやドイツで報告されている尿中代謝物レベルと同等であったことから、同等であることが推察される。さらに血中の一酸化窒素代謝物レベルと尿中3PBA レベルに有意な正の相関が検出されたことから、微量の殺虫剤曝露においても酸化ストレスを誘導する可能性を示唆することができた。
殺虫剤散布作業を専門とする職域集団を対象とした研究で、殺虫剤を散布していない従業員は他の職域従事者に比べて日常の殺虫剤曝露レベルが高いことが示唆された。

Research Products

• [Journal Article] Possible involvement of interleukin-6 (IL-6) in down-regulation of hepatic breast cancer resistance protein (Bcrp/ABCG2) in endotoxemic mice Bulletin of Aichi Bunkyo Women's College (2009)
  • Author(s): Zhao, Y., Cen, X., Abe, F., Ueyama, J., Hotta, K., Kato, S., Ito, S., Saga, S., Fukaya, Y., Wang, L., Wei, Y., Hasegawa,T
  • Journal Title: 30 Pages: 27-42
  • Peer Reviewed
• [Journal Article] Relationship between urinary pesticide metabolites and pest control operation among occupational pesticide sprayers (2009)
  • Author(s): KIMATA Akiko, KONDO Takaaki, UEYAMA Jun, YAMAMOTO Kanami, MOCHIZUKI Aiko, ASAI Kazumi, TAKAGI Kenji, OKAMURA Ai, WANG Dong, KAMIJIMA Michiro, NAKAJIMA Tamie, FUKAYA Yukio, SHIBATA Eiji, GOTOH Masahiro, SAITO Isao
  • Journal Title: Journal of Occupational Health 51 Pages: 100-105
  • NAID: 110007055426
  • Peer Reviewed
• [Journal Article] Possible involvement of interleukin-6 (IL-6) in down-regulation of hepatic breast cancer resistance protein (Bcrp/ABCG 2) in endotoxemic mice (2009)
  • Author(s): Zhao, Y. Cen, X. Abe, F, Ueyama, J., Hotta, K., Kato, S., Ito, S., Saga, S. Fukaya, Y., Wang, L., Wei, N., Hasegawa, T.
  • Journal Title: Bulletin of Aichi Bunkyo Women's College 30 Pages: 27-42
  • NAID: 110007329279
  • Peer Reviewed
• [Journal Article] Urinary excretion of 3-phenoxybenzoic acid in middle-aged and elderly general population of Japan (2009)
  • Author(s): Jun Ueyama, Akiko Kimata ; Michihiro Kamijima ; Nobuyuki Hamajima ; Yoshinori Ito ; Koji Suzuki ; Takashi. Inoue ; Kenji Takagi ; Isao Salto ; Ken-ichi Miyamoto ; Takaaki Hasegawa ; Takaaki Kondo
  • Journal Title: Environmental Research 109 Pages: 175-80
  • NAID: 120001008419
  • Peer Reviewed
• [Journal Article] Effect of the organophosphorus pesticide diazinon on glucose tolerancein type 2 diabetic rats (2008)
  • Author(s): Jun Ueyama, Michihiro Kamijima, Kazumi Asai, AikoMochizuki, Dong Wang, Takaaki Kondo, Toshiaki Suzuki, Kenji Takagi, Kenzo Takagi,Hiroaki Kanazawa, Ken-Ichi Miyamoto, Shinya Wakusawa, Takaaki Hasegawa
  • Journal Title: Toxicol. Lett 182 Pages: 42-47
  • Peer Reviewed
• [Journal Article] Effect of Thalidomide on Endotoxin-Induced Decreases in Activity and Expression of Hepatic Cytochrome (2008)
  • Author(s): Jun UEYAMA, Masayuki NADAI, Ying Lan ZHAO, Hiroaki KANAZAWA, Kenji TAKAGI, Takaaki KONDO, Kenzo TAKAGI, Shinya WAKUSAWA, Fumie ABE, Hiroko SAITO, Ken-ichi MIYAMOTO and Takaaki HASEGAWA
  • Journal Title: Biol. Pharm P4503A2 31 Pages: 1596-1600
  • Peer Reviewed
• [Journal Article] Involvement of multidrug resistance-associated protein 2 (ABCC2/Mrp2) in biliary excretion of micafungin in rats (2008)
  • Author(s): Abe F, Ueyama J, Kimata A, Kato M, Hayashi T, Nadai M, Saito H, Takeyama N, Noguchi H, Hasegawa T
  • Journal Title: Life Sci 83 Pages: 229-235
  • Peer Reviewed
• [Journal Article] Role of Plasma Proteins in Pharmacokinetics of Micafungin, an Antifungal Antibiotic, in Analbuminemic Rats (2008)
  • Author(s): Abe F, Ueyama J, Kawasumi N, Nadai M, Hayashi T, Kato M, Ohnishi M, Saito H, Takeyama N, Hasegawa T
  • Journal Title: Antimicrob Agents Chemother 52 Pages: 3454-3456
  • Peer Reviewed
• [Journal Article] Effebt of the organophosphorus pesticide diazinon on glucose tolerance in type 2 diabetic rats (2008)
  • Author(s): Jun Ueyama, Michihiro Kamijima, Kazumi Asai, AikoMochizuki, Dong Wang, Takaaki Kondo, Toshiaki Suzuki, Kenji Takagi, Kenzo Takagi, Hiroaki Kanazawa, Ken-Ichi Miyamoto, Shinya Wakusawa, Takaaki Hasegawa
  • Journal Title: Toxicol. Lett. 182 Pages: 42-47
  • Peer Reviewed
• [Journal Article] Effect of Thalidomide on Endotoxin-Induced Decreases in Activity and Expression of Hepatic Cytochrome P 450 3 A 2 (2008)
  • Author(s): Jun UEYAMA, Masayuki NADAI, Ying Lan ZHAO, Hiroaki KAN AZAWA, Kenji TAKAGI, Takaaki KONDO, Kenzo TAKAGI, Shinya WAKUSAWA, Fumie ABE, Hiroko SAITO, Ken-ichi MIYAMOTO and Takaaki HASEGAWA
  • Journal Title: Biol. Pharm. Bull. 31 Pages: 1596-1600
  • Peer Reviewed
• [Journal Article] Involvement of mUltidrug resistance-associated protedn 2 (ABCC2/Mrp 2) in biliary excretion of micafungin in rats (2008)
  • Author(s): Abe F, Ueyama J, Kimata A, Kato M, Hayashi T, Nadal. M, Saito H, Takeyama N, Noguchi H, Hasegawa T.
  • Journal Title: Life Sci. 83 Pages: 229-35
  • Peer Reviewed
• [Journal Article] Role of Plasma Proteins in Pharmacokinetics of Micafungin, an Antifungal Antibiotic, in Analbuminemic Rats (2008)
  • Author(s): Abe F, Ueyama J, Kawasumi N, Nadai M, Hayashi T, Kato M, Ohnishi M, Saito H, Takeyata N, Hasegawa T.
  • Journal Title: Antimicrob Agents Chemother 52 Pages: 3454-3456
  • Peer Reviewed
• [Journal Article] Urinary excretion of 3-phenoxybenzoic acid in middle-aged and elderly general population of Japan (2007)
  • Author(s): Jun Ueyama, Akiko Kimata, Michihiro Kamijima, Nobuyuki Hamajima, Yoshinori Ito, Koji Suzuki, Takashi Inoue, Kenji Takagi, Isao Saito, Ken-ichi Miyamoto, Takaaki Hasegawa, Takaaki Kondo
  • Journal Title: Environmental Research 109 Pages: 175-180
  • NAID: 120001008419
  • Peer Reviewed
• [Journal Article] Toxicity of diazinon and its metabolites increases in diabetic rats (2007)
  • Author(s): Ueyama J, Wang D, Kondo T, Saito I, Takagi K, Takagi K, Kamijima M, nakajima T, Miyamoto K, Wakusawa S, Hasegawa T
  • Journal Title: Toxicol. Lett 170 Pages: 229-237
  • NAID: 130007004136
  • Peer Reviewed
• [Journal Article] Biological monitoring of pyrethroid exposure for pest control workers in Japan (2007)
  • Author(s): Wang D, Kamijma M, Imai R, Suzuki T, Kameda Y, Asai K, Okamura A, Naito H, Ueyama J, Saito I, Nakajima T, Goto M, Shibata E, Kondo T, Takagi K, Takagi K, Wakusawa S
  • Journal Title: J Occup Health 49 Pages: 509-514
  • Peer Reviewed
• [Journal Article] Direct analysis of permethrins in human blood by SPE-GC/MS (2007)
  • Author(s): Ogata-Kawata H, Matsuda M, Onda N, Ueyama J, Kamijima M, Shibata E, Ogawa M, Endo Y
  • Journal Title: Chromatography 28 Pages: 119-124
  • NAID: 10020177315
  • Peer Reviewed
• [Journal Article] Permethrin may disrupt testosterone biosynthesis via mitochondrial membrane damage of Leydig cells in adult male mouse (2007)
  • Author(s): Zhang SY, Ito Y, Yamanoshita O, Yanagiba Y, Kobayashi M, Taya K, Li C, Okamura A, Miyata M, Ueyama J, Lee CH, Kamijima M, Nakajima T
  • Journal Title: Endocrinology 148 Pages: 3941-3349
  • Peer Reviewed
• [Journal Article] Toxicity of diazinon and its metabolites increases in diabetic rats (2007)
  • Author(s): Ueyama J, Wang D, Kondo T, Saito I, Takagi K, Takagi K, Kamijima M, nakajima T, Miyamoto K, Wakusawa S, Hasegawa T
  • Journal Title: Toxicol. Lett. 170 Pages: 229-237
  • NAID: 130007004136
  • Peer Reviewed
• [Journal Article] Biological monitoring of pyrethroid exposure for pest control workers in Japan (2007)
  • Author(s): Wang D, Kamijima M, Imai R, Suzuki T, Kameda Y, Asai K, Okamura A, Naito H, Ueyama J, Saito I, Nakajima T, Goto M, Shibata E, Kondo T, Takagi K, Takagi K, Wakusawa S
  • Journal Title: J Occup Health 49 Pages: 509-514
  • Peer Reviewed
• [Journal Article] Permethrin may disrupt testosterone biosynthesis via mitochondrial membrane damage of Leydig cells in adult male mouse. (2007)
  • Author(s): Zhang SY, Ito Y, Yamanoshita O, Yanagiba Y, Kobayashi M, Taya K, Li C, Okamura A, Miyata M, Ueyama J, Lee CH, Kamijima M, Nakajima T.
  • Journal Title: Endocrinology 148 Pages: 3941-3949
  • Peer Reviewed
• [Presentation] 害虫防除作業者集団におけるフェニトロチオン散布とその尿中代謝物量との関連 (2009)
  • Author(s): 岡村愛, 上島道浩, 上山純、 高木健次, 柴田英治, 内藤久雄、五藤雅博, 斉藤勲、那須民江
  • Organizer: 第7 9 回日本衛生学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2009-03-31
• [Presentation] 健常成人集団における血清8-iso-PGF2αと骨密度との関連 (2009)
  • Author(s): 近藤高明、上山純、木全明子、山本佳那美、鈴木康司、井上孝、伊藤宣則、浜島信之
  • Organizer: 第79回日本衛生学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2009-03-31
• [Presentation] ピレスロイド系殺虫剤代謝産物の体内動態における性差 (2009)
  • Author(s): 廣澤奈緒子, 上山純, 望月愛子, 木全明子, 高木健次, 近藤高明, 高木健三, 涌澤伸哉, 長谷川高明
  • Organizer: 第79回日本衛生学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2009-03-31
• [Presentation] 日本人中高齢者における尿中ピレスロイド系殺虫剤代謝物および血中酸化ストレス指標との関連性 (2009)
  • Author(s): 上山純, 木全明子, 上島通浩, 濱島信之, 鈴木康司, 井上孝, 伊藤宜則, 宮本謙一, 長谷川高明, 高木健次, 涌沢伸哉, 近藤高明
  • Organizer: 第79回日本衛生学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2009-03-31
• [Presentation] 害虫防除作業者集団におけるフェニトロチオン散布とその尿中代謝物量との関連 (2009)
  • Author(s): 岡村愛, 上島道浩, 上山純、高木健次, 柴田英治, 内藤久雄、五藤雅博, 斉藤勲、那須民江
  • Organizer: 第79回日本衛生学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2009-03-31
• [Presentation] Testicular toxicity in mice after combined exposure to pyrethroid and organophosphorus insecticides (2008)
  • Author(s): Dong Wang, Michihiro Kamijima, Ai Okamura, Yuki Ito, Yukie Yanagiba, Jun Ueyama, c and Tamie Nakajim
  • Organizer: 第11回環境ホルモン学会研究発表会
  • Place of Presentation: 東京
  • Year and Date: 2008-12-13
• [Presentation] ダイアジノンとcis-ペルメトリンの混合曝露によるマウス精巣への影響 (2008)
  • Author(s): 王棟、上島道浩、岡村愛、伊藤由起、柳場由絵、上山純、那須民江
  • Organizer: 平成20年日本産業衛生学会東海地方学会
  • Place of Presentation: 三重
  • Year and Date: 2008-11-22
• [Presentation] 一般生活集団における合成ピレスロイド系化合物の尿中代謝物濃度 (2008)
  • Author(s): 上山純、木全明子、上島通浩、高木健次、涌く澤伸哉、高木健三、斎藤勲、宮本謙一、 長谷川高明
  • Organizer: 第35 回日本トキシコロジー学会学術年会
  • Place of Presentation: 東京
  • Year and Date: 2008-06-26
• [Presentation] 一般生活集団における合成ピレスロイド系化合物の尿中代謝物濃度 (2008)
  • Author(s): 上山純、木全明子、上島通浩、高木健次、涌く澤伸哉、高木健三、斎藤勲、宮本謙一、長谷川高明
  • Organizer: 第35回日本トキシコロジー学会学術年会
  • Place of Presentation: 東京
  • Year and Date: 2008-06-26
• [Presentation] 一般生活者集団および殺虫剤散布職域集団における尿中3-フェノキシ安息香酸量の比較検討 (2008)
  • Author(s): 木全明子、上山純、近藤高明、山本佳那美、その他
  • Organizer: 日本衛生学会総会
  • Place of Presentation: 熊本
  • Year and Date: 2008-03-29
• [Presentation] 有機リン系殺虫剤ダイアジノンが及ぼす2型糖尿病モデルラットの耐糖能への影響 (2008)
  • Author(s): 浅井佳寿美、上山純、三河由佳、望月愛子、その他
  • Organizer: 日本薬学会第128年回
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-27
• [Presentation] 職業的有機リン系殺虫剤曝露が及ぼす血漿中βグルクロニダーゼ活性値への影響 (2008)
  • Author(s): 上山純、上島通浩、小笠原将人、木全明子、その他
  • Organizer: 日本薬学会第128年回
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-27
• [Presentation] ウェスタンブロット法の内部標準物質に及ぼすエンドトキシンの影響 (2008)
  • Author(s): 望月愛子、上山純、浅井佳寿美、王棟、その他
  • Organizer: 日本薬学会第128年回
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-27
• [Presentation] ラットにおけるミカファンギンの胆汁排泄におけるMrp2およびP糖タンパク質の関与 (2008)
  • Author(s): 安部文江、上山純、加藤美樹、灘井雅行、その他
  • Organizer: 日本薬学会第128年回
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-27
• [Presentation] Toxicity of Diazinon and Its Metabolites Increases in Diabetic Rats (2007)
  • Author(s): Jun Ueyama, Dong Wang, Takaaki Kondo, Mixhihiro Kamijima
  • Organizer: The seventh international symposium on biological monitoring in occupational & environmental health
  • Place of Presentation: Beijing, China
  • Year and Date: 2007-09-11
• [Presentation] Biological Monitoring of Exposure to Organophosphorus and Pyrethroid Insecticides in Japan - From the Viewpoint of Testicular Toxicity Assessment- (2007)
  • Author(s): Mixhihiro Kamijima, Jun Ueyama, Kenji Takagi, Takaaki Kondo
  • Organizer: The seventh international symposium on biological monitoring in occupational & environmental health
  • Place of Presentation: Beijing,China
  • Year and Date: 2007-09-11
• [Presentation] Biological Monitoring of Exposure to Organophosphorus and Pyrethroid Insecticides in Japan - From the Viewpoint of TesticularToxicity Assessment- (2007)
  • Author(s): Mixhihiro Kamijima, Jun Ueyama, Kenji Takagi, Takaaki Kondo, others
  • Organizer: The seventh international symposium on biological monitoring in occupational & environmental health
  • Place of Presentation: Beijing, China
  • Year and Date: 2007-09-11
• [Presentation] その他.有機リン系殺虫剤が及ぼすストレプトゾトシン誘発性糖尿病モデルラットへの影響 (2007)
  • Author(s): 王棟、上山純、林由美、上島通浩
  • Organizer: 第34回日本トキシコロジー学会学術年会
  • Place of Presentation: 東京
  • Year and Date: 2007-06-28
• [Presentation] 有機リン系殺虫剤が及ぼす2型糖尿病モデルラットへの影響 (2007)
  • Author(s): 浅井佳寿美、上山純、三河由佳、望月愛子
  • Organizer: 第34回日本トキシコロジー学会学術年会
  • Place of Presentation: 東京
  • Year and Date: 2007-06-28
• [Presentation] 有機リン系殺虫剤が及ぼすストレプトゾトシン誘発性糖尿病モデルラットヘの影響 (2007)
  • Author(s): 王棟、上山純、林由美、上島通浩、その他
  • Organizer: 第34回日本トキシコロジー学会学術年会
  • Place of Presentation: 東京
  • Year and Date: 2007-06-28
• [Presentation] 有機リン系殺虫剤が及ぼす2型糖尿病モデルラットヘの影響 (2007)
  • Author(s): 浅井佳寿美、上山純、三河由佳、望月愛子、その他
  • Organizer: 第34回日本トキシコロジー学会学術年会
  • Place of Presentation: 東京
  • Year and Date: 2007-06-28
• [Presentation] 衛生害虫防除作業者のレスロイド系薬剤使用と血中ペルメトリン及び尿中3-フェノキシ安息香酸の定量 (2007)
  • Author(s): 柴田英治、遠藤陽子、上山純、上島通浩
  • Organizer: 第80回日本産業衛生学会年会
  • Place of Presentation: 大阪
  • Year and Date: 2007-04-26
• [Presentation] 尿中殺虫剤代謝産物量を指標とした職業性の殺虫剤曝露評価の有用性 (2007)
  • Author(s): 木全明子、上山純、近藤高明、上島通浩
  • Organizer: 第80回日本産業衛生学会年会
  • Place of Presentation: 大阪
  • Year and Date: 2007-04-26