The effect of inhaled Di (2-ethylhexyl) phthalate exposued to prepubertal or pregnant female rats for the reproductive function and pharmacokinetics.

Research Project

Project/Area Number	19790408
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Hygiene
Research Institution	Health Sciences University of Hokkaido
Principal Investigator	KONDO Tomoko Health Sciences University of Hokkaido, 薬学部, 講師 (70374254)
Project Period (FY)	2007 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥7,070,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,170,000) Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2007: ¥2,000,000 (Direct Cost: ¥2,000,000)
Keywords	フタル酸 / DEHP / 吸入曝露 / 生殖 / 毒性 / 吸入暴露
Research Abstract	I evaluated the effects of inhaled Di(2-ethylhexyl)phthalate(DEHP) on the reproductive of immature female rats and next-generation effects. It was cleared that DEHP exposure via inhalation for immature female rats may advance puberty onset and alter postpubertal reproductive functions. In the study of DEHP inhalation for pregnant rats, fetal body weight was decreased and fetal testicular testosterone concentration and the expression of mRNA were also decreased.