Suppression of antitumor immunity and incidence of malignant mesothelioma induced by exposure to asbestos
| Project/Area Number |
19790411
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
MAEDA Megumi Kawasaki Medical School, 医学部, 助教 (20434988)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥3,680,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | アスベスト / 悪性中皮腫 / 腫瘍免疫 / IL-10 / TGF-β1 / 制御性T細胞 / CXCR3 / IFN-γ / MT-2 / TGF-61 |
|---|
| Research Abstract |
HTLV-1不死化T細胞株MT-2にアスベスト繊維の一種であるクリソタイルを低濃度長期曝露しクリソタイル耐性を獲得した細胞株を樹立することにより,アスベスト繊維曝露はCD4陽性T細胞のIFN-γ産生を抑制する一方で,IL-10,TGF-β1産生を促進することを示唆した。耐性株ではTh1型のT細胞に発現しており細胞遊走に関わるケモカインレセプターCXCR3の発現低下も生じており,アスベスト曝露による抗腫瘍免疫の減衰を推察できた。
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Report
(3 results)
Research Products
(19 results)
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[Journal Article] Immunological changes in mesothelioma patients and their experimental detection2008
Author(s)
Megumi Maeda, Yoshie Miura, Yasumitsu Nishimura, Shuko Murakami, Hiroaki Hayashi, Naoko Kumagai, Tamayo Hatayama, Minako Katoh, Naomi Miyahara, Shoko Yamamoto, Kazuya Fukuoka, Takumi Kishimoto, Takashi Nakano and Takemi Otsuki
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Journal Title
Clinical Medicine : Circulatory, Respiratory and Pulmonary Medicine 2
Pages: 11-17
Related Report
Peer Reviewed
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