Involvement of connexin 43 in catecholamine-induced cardiomyopathy

• Project/Area Number: 19790443
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Legal medicine
• Research Institution: The University of Tokyo
• Principal Investigator: SHINTANI Kaori The University of Tokyo, 大学院医学系研究科, 助教 (50345047)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,100,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥1,800,000 (Direct Cost: ¥1,800,000)
• Keywords: コネキシン / 心臓突然死 / ギャップジャンクション / コネキシン43 / 心筋障害 / 収縮帯壊死 / 心臟突然死

Research Abstract

心交感神経活性の亢進は、心筋収縮不全や心筋傷害といったカテコールアミン心筋障害を引き起こす。本研究では、カテコールアミンの過剰分泌や虚血によって引き起こされると考えられている収縮帯壊死がギャップ結合を介して伝播する機序を解明した。ギャップ結合を構成するコネキシン43 が虚血により介在板で増加し、ギャップ結合を介した細胞間情報伝達を活性化することにより、収縮帯壊死がこの活性化したギャップ結合を介して伝播していた。

Research Products

• [Journal Article] Ischemia enhances translocation of connexin43 and gap junction intercellular communication. (2009)
  • Author(s): Shintani-Ishida K, Unuma K, Yoshida K.
  • Journal Title: thereby propagating contraction band necrosis after reperfusion. Cir J (in press)
  • Peer Reviewed
• [Journal Article] Ischemia enhances translocation of connexin43 and gap junction intercellular communication, thereby propagating contraction band necrosis after reperfusion (2009)
  • Author(s): Shintani-Ishida K
  • Journal Title: Circulation Journal (In press)(印刷中)(掲載確定)
  • Peer Reviewed
• [Journal Article] Hemichannels in cardiomyocytes open transiently during ischemia and contribute to reperfusion injury following brief ischemia. (2007)
  • Author(s): Shintani-Ishida K, Uemura K, Yoshida K.
  • Journal Title: Am J Physiol Heart Circ Physiol 293 Pages: 1714-1720
  • Peer Reviewed
• [Journal Article] Ischemia promotes calpain-mediated degradation of p120-catenin in SH-SY5Y cells. (2007)
  • Author(s): Ohno H, Uemura K, Shintani-Ishida K, Nakamura M, Inomata M, Yoshida K.
  • Journal Title: Biochem Biophys Res Commun 353 Pages: 547-552
  • Peer Reviewed
• [Journal Article] Sex difference in norepinephrine surge in response to psychological stress through nitric oxide in rats. (2007)
  • Author(s): Uji M, Yoshida K, Shintani-Ishida K, Morimoto K.
  • Journal Title: Life Sci 80 Pages: 860-866
  • Peer Reviewed
• [Journal Article] Sex difference in norepinephrine surge in response to psychological stress through nitric oxide in rats. (2007)
  • Author(s): Uji M, Yoshida K, Shintani-Ishida K, Morimoto K.
  • Journal Title: Life Sci 80(9) Pages: 860-866
  • Peer Reviewed
• [Journal Article] Ischemia promotes calpain-mediated degradation of p120-cateninin SH-SY5Y cells. (2007)
  • Author(s): Ohno H, Uemura K, Shintani-Ishida K, Nakamura M, Inomata M, Yoshida K.
  • Journal Title: Biochem Biophys Res Commun 353 Pages: 547-552
  • Peer Reviewed
• [Presentation] Why is contraction band necrosis clustered exclusively within the ischemic area? (2008)
  • Author(s): Shintani-Ishida K, Yoshida K.
  • Organizer: The 7th International Symposium Advances in Legal Medicine
  • Place of Presentation: 大阪市 中央公会堂
  • Year and Date: 2008-09-03
• [Presentation] Why is contraction band necrosis clustered exclusively within the ischemic area? (2008)
  • Author(s): Shintani-Ishida K
  • Organizer: The 7^<th> Symposium Advances in Legal Medicine
  • Place of Presentation: 大阪(中央公会堂)
  • Year and Date: 2008-09-03
• [Presentation] Gap junctionsは心筋虚血再灌流時におけるcontraction band の細胞間伝播に関与する (2008)
  • Author(s): 新谷 香, 吉田謙一 他
  • Organizer: 第92次日本法医学会総会
  • Place of Presentation: 長崎市 ブリックホール
  • Year and Date: 2008-04-25
• [Presentation] Gap junctionsは心筋虚血再灌流時におけるcontraction bandの細胞間伝播に関与する (2008)
  • Author(s): 新谷香
  • Organizer: 第92次日本法医学会総会
  • Place of Presentation: 長崎(長崎ブリックホール)
  • Year and Date: 2008-04-25
• [Presentation] Brief Ischemia Enhances Gap Junction Intracellular Communication Thereby Promoting Cell-to-Cell Spread of Cell Death in Rat Heart (2008)
  • Author(s): 新谷香, 吉田謙一 他
  • Organizer: 第72回日本循環器学会総会・学術集会
  • Place of Presentation: 福岡市福岡国際会議場
  • Year and Date: 2008-03-28
• [Presentation] Brief Ischemia Enhances Gap Junction Intracellular Communication, Thereby Promoting Cell-to-Cell Spread of Cell Death in Rat Heart. (2008)
  • Author(s): 新谷香、吉田謙一, 他
  • Organizer: 第72回日本循環器学会総会・学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2008-03-28
• [Presentation] Hemichannelsのカルシウム濃度依存的開閉と虚血再灌流傷害への関与 (2007)
  • Author(s): 新谷香, 吉田謙一 他
  • Organizer: 第91次日本法医学会総会
  • Place of Presentation: 秋田市 秋田ビューホテル
  • Year and Date: 2007-05-17
• [Presentation] Hemichannelsのカルシウム濃度依存的開閉と虚血再灌流傷害への関与. (2007)
  • Author(s): 新谷香、吉田謙一, 他
  • Organizer: 第91次日本法医学会総会
  • Place of Presentation: 秋田
  • Year and Date: 2007-05-17
• [Remarks] ホームページ
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• [Remarks]
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• [Remarks]
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