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Analysis of cytotoxic activity against small cell lung cancer of sesquiterpene lactone newly isolated from Lindera strychnifolia

Research Project

Project/Area Number 19790461
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionAichi Gakuin University

Principal Investigator

OHNO Takamasa  Aichi Gakuin University, 薬学部, 講師 (80345777)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,620,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywords小細胞肺癌 / セスキテルペンラクトン / 薬剤耐性肺癌 / シスプラチン耐性 / SBC-3 / CDDP / 細胞周期
Research Abstract

生薬・烏薬から単離した新規セスキテルペンラクトンが小細胞肺癌細胞、およびそのシスプラチン耐性株に対して細胞傷害性を示した。次に、各種阻害剤を用いて、新規セスキテルペンラクトンが示す細胞傷害性の機序に検討を加えたところ、細胞内還元型グルタチオンと結合して枯渇させた結果、細胞内が酸化的状態になり細胞傷害性を示すものと考えられた。実際に活性酸素の産生を確認した。また、シスプラチン耐性株を皮下に移植したヌードマウスに新規セスキテルペンを投与したところ、腫瘍増殖抑制作用が認められた。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (2 results)

All 2007

All Presentation (2 results)

  • [Presentation] Cytotoxic activity against small cell lung cancer of sesquiterpene lactone newly isolated from Lindera strychnifolia2007

    • Author(s)
      Takamasa Ohno
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-03
    • Related Report
      2008 Final Research Report
  • [Presentation] Cytotoxic activity against small cell lung cancer of sesquiterpene lactone newly isolated from Lindera strychnifolia2007

    • Author(s)
      Takamasa Ohno
    • Organizer
      第66回 日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-03
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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