Establishment of in-vivo histological diagnosis by using endo-cytoscopy system toward automatic diagnosis of gastrointestinal neoplasia

• Project/Area Number: 19790469
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Gastroenterology
• Research Institution: The University of Tokyo
• Principal Investigator: FUJISHIRO Mitsuhiro The University of Tokyo, 医学部・附属病院, 准教授 (70396745)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,800,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥600,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥1,200,000 (Direct Cost: ¥1,200,000)
• Keywords: 超拡大内視鏡 / 内視鏡的組織診断 / 内視鏡的自動診断 / 仮想生検 / 消化管腫瘍

Research Abstract

The investigation to determine an appropriate staining regimen for endocytoscopy revealed that the optimum conditions for endocytoscopic observation were obtained after staining with 1% methylene blue in the esophagus and with 0.25% toluidine blue in the stomach and the colon, after 60 seconds of exposure to the dye. When the conditions were applied to the living beagles, reliable observations in the stomach were not obtained in the stomach due to thick mucous layer on the surface epithelia. Focusing on the esophageal observations, in-vivo endocytoscopic images were quite similar with the horizontal histology of fixed specimens with H&E staining. We obtained a novel finding that computer-assisted analysis of nuclear density between malignant and normal epithelia can lead to automatic diagnosis by using the endocytoscopy.

Research Products

• [Journal Article] Multi-center survey regarding the management of anticoagulation and anti platelet therapy for endoscopic procedures in Japan (2009)
  • Author(s): Fujishiro M, Oda I, Yamamoto Y, Akiyama J, Ishii N, Kakushima N, Fujiwara J, Morishita S, Kawachi H, Taniguchi H, Gotoda T
  • Journal Title: J Gastroenterol Hepatol 24 Pages: 214-218
  • Peer Reviewed
• [Journal Article] Endoscopic submucosal dissection for esophageal squamous cell neoplasms (2009)
  • Author(s): Fujishiro M, Kodashima S, Goto O, Ono S, Niimi K, Yamamichi N, Oka M, Ichinose M, Omata M
  • Journal Title: Dig Endosc. 21 Pages: 109-115
  • NAID: 10025172131
  • Peer Reviewed
• [Journal Article] Indications, techniques, and outcomes of endoscopic submucosal dissection for esophageal squamous cell carcinoma (2009)
  • Author(s): Fujishiro M, Kodashima S
  • Journal Title: Esophagus 6 Pages: 143-148
  • Peer Reviewed
• [Journal Article] Japan aims toward appropriate concomitant use of antiplatelets and antis ecretory aaents? (2009)
  • Author(s): Fujishiro M
  • Journal Title: Internal Medicine 48 Pages: 1845-1846
  • Peer Reviewed
• [Journal Article] Endoscopic submucosal dissection for colorectal neoplasms (2009)
  • Author(s): Fujishiro M
  • Journal Title: World J Gastrointest Endosc 1 Pages: 32-38
  • Peer Reviewed
• [Journal Article] Locked nucleic acid in situ hybridization analysis of miR-21 expression during colorectal cancer development (2009)
  • Author(s): Yamamichi N, Shimomura R, Inada K, Sakurai K, Haraguchi T, Ozaki Y, Fujita S, Mizutani T, Furukawa C, Fujishiro M, Ichinose M, Shiogama K, Tsutsumi Y, Omata M, Iba H
  • Journal Title: Clin Cancer Res 15 Pages: 4009-4016
  • Peer Reviewed
• [Journal Article] Cdx2 and the Brm-type SWI/SNF complex cooperatively regulate villin expression in gastrointestinal cells (2009)
  • Author(s): Yamamichi N, Inada K, Furukawa C, Sakurai K, Tando T, Ishizaka A, Haraguchi T, Mizutani T, Fujishiro M, Shimomura R, Oka M, Ichinose M, Tsutsumi Y, Omata M, Iba H
  • Journal Title: Exp Cell Res. 315 Pages: 1779-1789
  • Peer Reviewed
• [Journal Article] Novel image-enhanced endoscopy with i-scan technology (2009)
  • Author(s): Kodashima S, Fujishiro M
  • Journal Title: World J Gastroenterol. 16 Pages: 1043-1049
  • Peer Reviewed
• [Journal Article] Endoscopic submucosal dissection for colonic laterally spreading tumors is difficult after target tattooing (2009)
  • Author(s): Ono S, Fujishiro M, Goto O, Kodashima S.Omata M
  • Journal Title: Gastrointest Endosc 69 Pages: 763-766
  • Peer Reviewed
• [Journal Article] Technical feasibility of endoscopic submucosal dissection for early gastric cancer in patients taking anti-coagulants or anti-platelet agents (2009)
  • Author(s): Ono S, Fujishiro M, Niimi K, Goto O, Kodashima S, Yamamichi N.Omata M
  • Journal Title: Dig Liver Dis 41 Pages: 725-728
  • Peer Reviewed
• [Journal Article] Long-term outcomes of endoscopic submucosal dissection for superficial esophageal squamous cell neoplasms (2009)
  • Author(s): Ono S, Fujishiro M, Niimi K, Goto O, Kodashima S, Yamamichi N, Omata M
  • Journal Title: Gastrointest Endosc 70 Pages: 860-866
  • Peer Reviewed
• [Journal Article] Predictors of postoperative stricture after esophageal endoscopic submucosal dissection for superficial squamous cell neoplasms (2009)
  • Author(s): Ono S, Fujishiro M, Niimi K, Goto O, Kodashima S, Yamamichi N, Omata M
  • Journal Title: Endoscopy. 41 Pages: 661-665
  • Peer Reviewed
• [Journal Article] Retrospective analysis on the management of anticoagulants and antiplatelet agents for scheduled endoscopy (2009)
  • Author(s): Ono S, Fujishiro M, Hirano K, Niimi K, Goto O, Kodashima S, Yamamichi N, Koike K
  • Journal Title: J Gastroenterol. 44 Pages: 1185-1189
  • NAID: 10027213537
  • Peer Reviewed
• [Journal Article] En bloc resection of cardia cancer and lipoma with endoscopic submucosal dissection (2009)
  • Author(s): Ono S, Fujishiro M, Goto O, Kodashima S, Omata M
  • Journal Title: Dig Liver Dis. 41 Pages: 237-237
  • Peer Reviewed
• [Journal Article] Curative ESD for intraepithelial esophageal carcinoma with leiomyoma mimicking submucosal invasive carcinoma (2009)
  • Author(s): Niimi K, Kodashima S, Ono S, Goto O, Yamamichi N, Fujishiro M
  • Journal Title: World J Gastrointest Endosc 1 Pages: 68-71
  • Peer Reviewed
• [Journal Article] Subserosal injection of hyaluronic acid may prevent perforation after end oscopic resection (2009)
  • Author(s): Niimi K, Kodashima S, Ono S, Goto O, Yamamichi N, Fujishiro M
  • Journal Title: World J Gastrointest Endosc 1 Pages: 61-64
  • Peer Reviewed
• [Journal Article] Feasibility of electrocautery snaring as the final step of endoscopic submucosal dissection for stomach epithelial neoplasms (2009)
  • Author(s): Goto O, Fujishiro M, Kodashima S, Kakushima N, Ono S, Yahagi N, Omata M
  • Journal Title: Dig Liver Dis 41 Pages: 26-30
  • Peer Reviewed
• [Journal Article] Is it possible to predict procedural time of endoscopic submucosal dissection for early gastric cancer? (2009)
  • Author(s): Goto O, Fujishiro M, Kodashima S, Ono S, Omata M
  • Journal Title: J Gastroenterol Hepatol. 24 Pages: 379-383
  • Peer Reviewed
• [Journal Article] A second-look endoscopy after endoscopic submucosal dissection(ESD)for gastric epithelial neoplasm may be unnecessary : a retrospective analysis of post-ESD bleeding (2009)
  • Author(s): Goto O, Fujishiro M, Kodashima S, Ono S, Niimi K, Hirano K, Yamamichi N, Koike K
  • Journal Title: Gastrointest Endosc 71 Pages: 241-248
  • Peer Reviewed
• [Journal Article] Outcomes of endoscopic submucosal dissection for early gastric cancer with special reference to validation for curability criteria (2009)
  • Author(s): Goto O, Fujishiro M, Kodashima S, Ono S, Omata M
  • Journal Title: Endoscopy 41 Pages: 118-122
  • Peer Reviewed
• [Journal Article] En bloc resection of cardia cancer and lipoma with endoscopic submucosal dissection (2009)
  • Author(s): Ono S, Fujishiro M, Goto O, K odashima S, Omata M
  • Journal Title: Digestive Liver Disease 41 Pages: 237-237
  • Peer Reviewed
• [Journal Article] Multi-center survey regarding the management of anticoagulation and antiplatelet therapy for endoscopic procedures in Japan (2009)
  • Author(s): Fujishiro M, Oda I, Yamamoto Y, Akiyama J, Ishii N, Kakushima N, Fujiwara J, Morishita S, Kawachi H, Taniguchi H, Gotoda T
  • Journal Title: Journal of Gastroenterology and Hepatology 24 Pages: 214-218
  • Peer Reviewed
• [Journal Article] Detailed comparison between endo-cytoscopy and horizontal histology of an esophageal intraepithelial squamous cell carcinoma. (2008)
  • Author(s): Fujishiro M, Kodashima S, Takubo K, Kakushima N, Omata M
  • Journal Title: Dis Esophagus 21 Pages: 181-185
  • Peer Reviewed
• [Journal Article] エンドサイトスコープを用いた自動診断の可能性 (2008)
  • Author(s): 小田島慎也、藤城光弘、小俣政男
  • Journal Title: 臨床消化器内科 vol.23No.5 Pages: 657-661
• [Journal Article] Detailed comparison between endo-cytoscopy and horizontal histology of an esophageal intraepithelial squamous cell carcinoma (2008)
  • Author(s): Fujishiro M, Kodashima S, Takubo K, Kakushima N, Omata M
  • Journal Title: Disease of the Esophagus 21 Pages: 181-185
  • Peer Reviewed
• [Journal Article] Endoscopic submucosal dissection for gastric cancer (2008)
  • Author(s): Fujishiro M
  • Journal Title: Current Treatment Options in Gastroenterology 11 Pages: 119-124
  • Peer Reviewed
• [Journal Article] Endoscopic submucosal dissection as a staging measure may not lead to worse prognosis in early gastric cancer patients with additional gastrectomy (2008)
  • Author(s): Goto O, Fujishiro M, Kakushima N, Kodashima S, Ono S, Yamaguchi H, Nomura S, Kaminishi M, Omata M
  • Journal Title: Digestive Liver Diseasd 40 Pages: 293-297
  • Peer Reviewed
• [Journal Article] Cancer high-risk subjects identified by serum pepsinogen tests : outcomes after 10-year follow-up in asymptomatic middle-aged males. Cancer Epidemiol Biomarkers Prev (2008)
  • Author(s): Yanaoka K, Oka M, Mukoubayashi C, Yoshimura N, Enomoto S, Iguchi M, Magari H, Utsunomiya H, Tamai H, Arii Ohata H, Fujishiro M, Takeshita T, Mohara O. Ichinose M
  • Journal Title: Cancer Epidemiology, Biomarkers & Prevention 17 Pages: 838-845
  • Peer Reviewed
• [Journal Article] Efficacy and safety of endoscopic submucosal dissection for gastric cancer in patients with liver cirrhosis (2008)
  • Author(s): Ogura K, Okamoto M, Sugimoto T, Yahagi N, Fujishiro M, Kakushima N, Kodashima S, Kawabe T, Omata M
  • Journal Title: Endoscopy 40 Pages: 443-445
  • Peer Reviewed
• [Journal Article] Successful en bloc resection of superficial esophageal cancer treated by endoscopic submucosal dissection with a splash-needle(with video) (2008)
  • Author(s): Fujishiro M, Kodashima S, Goto O, Ono S, Muraki Y, Kakushima N, Omata M
  • Journal Title: Endoscopy 40
  • Peer Reviewed
• [Journal Article] Feasibility of electrocautery snaring as the final step of endoscopic submuco sal dissection for stomach epithelial neoplasms (2008)
  • Author(s): Goto O, Fujishiro M, Kodashima S, Kakushima N, Ono S, Yahagi N, Omata M
  • Journal Title: Digestive Liver Disease 41 Pages: 26-30
  • Peer Reviewed
• [Journal Article] Endoscopic submucosal dissection for gastrointestinal neoplasms (2008)
  • Author(s): Kakushima N, Fujishiro M
  • Journal Title: World Journal of Gastroenterology 13. 14 Pages: 2362-2367
  • Peer Reviewed
• [Journal Article] Risk of gastric cancer in asymptomatic, middle-aged Japanese subjectsbased on serum pepsinogen and Helicobacter pylori antibody levels (2008)
  • Author(s): Yanaoka K, Oka M, Yoshimura N, Mukoubayashi C, Enomots S, Iguchi M, Isagari H, Utsunomiya H, Tamai H, Arii K, Yamamichi N, Fujishiro M, Takeshita T, Mohara O, Ichinose M
  • Journal Title: International Journal of Cancer 123 Pages: 917-926
  • Peer Reviewed
• [Journal Article] Early gastric cancer shows different associations with adipose tissue volume depending on histological type (2008)
  • Author(s): Otani K, Kitayama J, Kaisaki S, Ishigami H, Hidemura A, Fuiishiro M, Omata M, Nagawa H
  • Journal Title: Gastric Cancer 11 Pages: 86-95
  • Peer Reviewed
• [Journal Article] Perspective on the practical indications of endoscopic submucosal dissection of gastrointestinal neoplasms (2008)
  • Author(s): Fuiishiro M
  • Journal Title: World Journal of Gastroenterology 14 Pages: 4289-4295
  • Peer Reviewed
• [Journal Article] Submucosal injection of normal saline may prevent unexpected deep thermal injury of argon plasma coagulation in an in vivo porcine stomach (2008)
  • Author(s): Fujishiro M, Kodashima S, Ono S, Goto O, Yamamichi N, Yahagi N, Kashimura K, Matsuura T, Iguchi M, Oka M, Ichinose M, Omata M
  • Journal Title: Gut and Liver 2 Pages: 95-98
  • Peer Reviewed
• [Journal Article] Submerging endoscopic submucosal dissection leads to successful en bloc resection of colonic laterally spreading tumor with submucosal fat (2008)
  • Author(s): Ono S, Fujishiro M, Kodashima S, Goto O, Omata M
  • Journal Title: Gut and Liver 2 Pages: 209-212
  • Peer Reviewed
• [Journal Article] Technical feasibility of endoscopic submucosal dissection for the gastroi ntestinal epithelial neoplasms with a splash-needle (2008)
  • Author(s): Fujishiro M, Kodashima S, Goto O, Ono S, Muraki Y, Kakushima N, Omata M
  • Journal Title: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 18 Pages: 592-597
  • Peer Reviewed
• [Journal Article] Ex vivo pilot study using computed analysis of endo-cytoscopic images to differentiate normal and malignant squamous cell epithelia in the esophagus. (2007)
  • Author(s): Kodashima S, Fujishiro M, Takubo K, Kammori M, Nomura S, Kakushima N, Muraki Y, Goto O, Ono S, Kaminishi M, Omata M
  • Journal Title: Dig Liver Dis 39 Pages: 762-766
  • Peer Reviewed
• [Journal Article] Munlticenter study design of the ex vivo evaluation of endocytoscopy in esophagela squamous cell carcinoma. (2007)
  • Author(s): Muto M, Fujishiro M, Sato Y, Kaise M, Niwa Y, Kato M, Takubo K
  • Journal Title: Dig Endosc 19
  • Peer Reviewed
• [Journal Article] Comparison among endo-cytoscopy, cytology and histology of an esophageal intraepithelial carcinoma. (2007)
  • Author(s): Fujishiro M, Kodashima S, Takubo K, Kakushima N, Omata M
  • Journal Title: Dig Endosc 19
  • NAID: 10024015268
  • Peer Reviewed
• [Journal Article] Early squamous cell carcinoma of the oesophagus: the Japanese viewpoint. (2007)
  • Author(s): Takubo K, Aida J, Sawabe M, Kurosumi M, Arima M, Fujishiro M, Arai T
  • Journal Title: Histopathology 51 Pages: 733-742
  • Peer Reviewed
• [Journal Article] Potential and present limitation of endo-cytoscopy in diagnosis of esophageal squamous cell carcinoma: a multi-center ex vivo pilot study. (2007)
  • Author(s): Fujishiro M, Takubo K, Sato Y, Kaise M, Niwa Y, Kato M, Muto M
  • Journal Title: Gastrointest Endosc 66 Pages: 551-555
  • Peer Reviewed
• [Journal Article] Appropriate mixture of hyaluronic acid, glucose and glycerin for a submucosal fluid cushion during endoscopic submucosal dissection in the dogstomach. (2007)
  • Author(s): Fujishiro M, Kakushima N, Kodashima S, Kashimura K, Matsuura T, Muraki Y, Tateishi A, Omato M.
  • Journal Title: Dig Eadosc 9 Pages: 26-31
  • NAID: 10021273122
  • Peer Reviewed
• [Journal Article] Technical feasibility of endoscopic submucosal dissection for stomach neoplasms in the elderly Japanese population. (2007)
  • Author(s): Kakushima N, Fujishiro M, Kodashima S, Muraki Y, Tateishi A, Yahagi N, Omata M
  • Journal Title: J Gastroenterol Hepatol 21 Pages: 311-314
  • Peer Reviewed
• [Journal Article] Endoscopic submucosal dissection of stomach neoplasms after unsuccessful endoscopic resection. (2007)
  • Author(s): Fujishiro M, Goto O, Kakushima N, Kodashima S, Muraki Y, Omats M.
  • Journal Title: Dig Liver Dis 39 Pages: 566-571
  • Peer Reviewed
• [Journal Article] Outcomes of endoscopic submucosal dissection for colorectal epithelial neoplasms in 200 consecutive cases. Clin Gastroenterol Hepatol (2007)
  • Author(s): Fujishiro M, Yahagi N, Kakushi ma N, Kodashima S, Muraki Y, Ono S, Yamamichi N, Tateishi A, Oka M, Ogura K, Kawabe T, Ichinose M, Omata M.
  • Journal Title: Clin Gastroenterol Hepatol 5 Pages: 678-683
  • Peer Reviewed
• [Journal Article] Potent induction therapy with interferon and ribavirin combiation therapy does not achieve a higher sustained virological response rate in chronic hepatitis C with genotype lb and high hepatitis C virus RNA level. (2007)
  • Author(s): Enomoto S, Tamai H, Oka M, Shingaki N, Shiraki T, Takeuchi M, Deguchi H, Magari H, Inoue I, Iguchi M, Yanaoka K, Arii K, Fujishiro M, Yahagi N, Yotsuyanagi H, Ichinose M.
  • Journal Title: Hepatol Res. 37 Pages: 692-700
  • Peer Reviewed
• [Journal Article] Ex vivo Pilot study using computed analysis of endo-cytoscopic images ta differentiate normal and malignant squamous cell epithelia in the esophagus. (2007)
  • Author(s): Kodashima S, Fujishiro M, Takubo K, Kammori M, Nomura S, Kakushima N, Muraki Y, Goto O, Ono S, Kaminishi M, Omata M.
  • Journal Title: Dig Liver Dis 39 Pages: 762-766
  • Peer Reviewed
• [Journal Article] Munlticenter study design of the ex viva evaluation of endocytoscopy inesophagela squamous cell carcinoma (2007)
  • Author(s): Muto M, Fujishiro M, Sato Y, Kaise M, Niwa Y, Kato M, Takubo K
  • Journal Title: Dig Endosc 19 Pages: 153-155
  • Peer Reviewed
• [Journal Article] Early squamous cell carcinoma of the oesophagus: the Japanese viewpoint. (2007)
  • Author(s): Takubo K, Aida J, Sawabe M, Kurosumi M, Arima M, Fujishiro M, Arai T.
  • Journal Title: Histopathology 51 Pages: 733-742
  • Peer Reviewed
• [Journal Article] Potential and present limitation of endo-cytoscopy in diagnosis of esophageal squamous cell carcinoma: a multi-center ex vivo pilot study. (2007)
  • Author(s): Fujishiro M, Takubo K, Sato Y, Kaise M, Niwa Y, Kato M, Muto M.
  • Journal Title: Gastrointest Endosc 66 Pages: 551-555
  • Peer Reviewed
• [Journal Article] Early esophageal cancer in patients with a history of gastrectomy for gastric cancer. (2007)
  • Author(s): Yoshizawa N, Yamaguchi H, Nozaki K, Yamada K, Mafune K, Fujishiro M, Nomura S, Kaminishi M.
  • Journal Title: Esophagus 4 Pages: 99-102
  • Peer Reviewed
• [Journal Article] Intensive follow-up may be necessary for the endoscopically-resected esophageal squamous cell carcinoma invading the muscularis mucosae. (2007)
  • Author(s): Fujishiro M, Nomura S, Yamada K, Kaminishi M, Omata M.
  • Journal Title: Endoscopy 39 Pages: 1111-1111
  • Peer Reviewed
• [Journal Article] Developmentally regulated expression of matrix metalloproteinases (MMPs) during fetal rat colon morphogenesis. (2007)
  • Author(s): Kurakata H, Oka M, Matsubara Y, Niwa T, Utsunomiya H, Fujishiro M, Miki K, Fukamachi H, Kubota S, Ichinose M.
  • Journal Title: Dev Growth Differ 50 Pages: 41-48
  • Peer Reviewed
• [Journal Article] Frequent loss of Brm expression in gastric cancer correlates with histological features and differentiation state. (2007)
  • Author(s): Yamamichi N, Inada K, Ichinose M, Yamamichi-Nishina M, Mizutani T, Watanabe H, Shiogama K, Fujishiro M, Okazaki T, Yahagi N, Haraguchi T, Fujita S, Tsutsumi Y, Omata M, Iba H.
  • Journal Title: Cancer Res 67 Pages: 10727-10735
  • Peer Reviewed
• [Journal Article] Comparison among endo-cytoscopy, cytology and histology of an esophageal intraepithelial carcinoma. (2007)
  • Author(s): Fujishiro M, Kodashima S, Takubo K, Kakushima N, Omata M.
  • Journal Title: Dig Endosc 19 Pages: 156-159
  • NAID: 10024015268
  • Peer Reviewed
• [Presentation] A second-look endoscopy after endoscopic submucosal dissection(ESD)for gastric epithelial neoplasm may be unnecessary : a retrospective analysis of post-ESD bleeding (2009)
  • Author(s): Osamu Goto, Mitsuhiro Fujishiro
  • Organizer: UEGW
  • Place of Presentation: Londono, イギリス
  • Year and Date: 2009-11-21
• [Presentation] s it necessary for elderly population to undergo additional colonoscopy after negative colonoscopy? (2009)
  • Author(s): Keiko Niimi, Mitsuhiro Fujishiro
  • Organizer: UEGW
  • Place of Presentation: London, イギリス
  • Year and Date: 2009-11-21
• [Presentation] A More Effect System for Gastric Cancer Screening Using the Combination Assay of Serum Anti-Helico-Bacter pylori IgG Antibody and Serum Peosinogen Levels (2009)
  • Author(s): Mitsuhiro Fujishiro
  • Organizer: American College of Gastroenterology
  • Place of Presentation: San Diego, USA
  • Year and Date: 2009-10-26
• [Presentation] Long-term outcomes of endoscopic submucosal dissection for superficial esophageal squamous cell carcinoma (2009)
  • Author(s): Satoshi Ono, Mitsuhiro Fujishiro
  • Organizer: DDW
  • Place of Presentation: Chicago, USA
  • Year and Date: 2009-05-31
• [Presentation] Is it possible to predict procedural time of endoscopic submucosal dissection for early gastric cancer? (2008)
  • Author(s): Goto O, Fujishiro M, Kodashima S, Ono S. Omata M
  • Organizer: United European Gastroenterology Week 2008
  • Place of Presentation: Vienna
  • Year and Date: 2008-10-21
• [Presentation] Treatment outcomes of endoscopic submucosal dissection for early gastric caneer in patients with anti-coagulants or anti-platelet agents (2008)
  • Author(s): Ono S, Fujishiro M, Kodashima S, Goto O.Omata M
  • Organizer: United European Gastroenterology Week 2008
  • Place of Presentation: Vienna
  • Year and Date: 2008-10-21
• [Presentation] Endo-Cytoscopy Systemを用いた食道扁平上皮癌の診断 (2008)
  • Author(s): 小田島慎也、藤城光弘、小俣政男
  • Organizer: 第62回日本食道学会
  • Place of Presentation: 東京
  • Year and Date: 2008-06-21
• [Presentation] Feasibility of electrocautery snaring as the final step of endoscopic submucos, dissection for stomach epithelial neoplasms (2008)
  • Author(s): Goto O, Fujishiro M, Kodashima S, Ono S, Omata M
  • Organizer: Digestive Disease Week 2008
  • Place of Presentation: San Diego
  • Year and Date: 2008-05-18
• [Presentation] Endo-Cytoscopy Systemを用いた食道病変の画像解析-正常粘膜と扁平上表皮の比較- (2007)
  • Author(s): 小田島慎也、藤城光弘、田久保海誉、角嶋直美、村木洋介、建石綾子、神森眞、野村幸世、川邉隆夫、上西紀夫、小俣政男
  • Organizer: 第73回日本消化器内視鏡学会総会
  • Place of Presentation: 東京
  • Year and Date: 2007-05-09
• [Presentation] Computed analysis of endo-cytoscopie images to differentiate normal and malignant squamous cell epithlia in the esophagus. (2007)
  • Author(s): Kodashima S, Fujishiro M, Takubo K, Kmmori M, Nomura S, Kakushima N、Muraki Y, Kaminishi M, Omata M
  • Organizer: KJSGE2007
  • Place of Presentation: 韓国
• [Book] Current perspective on endocytoscopic diagnosis in the esophagus based on the multicenter study at the endoscopy forum Japan.(Niwa H, Tajiri H, Nakajima M, Yasuda K (Eds), New challenge in gastrointestinal endoscopy.) (2008)
  • Author(s): Fujishiro M
  • Publisher: Springer-Verlag
• [Book] Stomach. In : Conio M, Siersema P, Repici A, Ponchon T (Eds) : Endoscopic Mucosal Resection (2008)
  • Author(s): Kakushima N, Fujishiro M. Gotoda T
  • Publisher: Wiley-Blackwell, USA
• [Book] Current perspective on endocytoscopic diagnosis in the esophagus based on the multicenter study at the endoscopy forum Japan. In : Niwa H, Tajiri H, Nakajima M, Yasuda K (Eds) : New challenee in gastrointestinal endoscopy (2008)
  • Author(s): Fujishiro M
  • Publisher: Springer-Verlag Tokyo, Japan
• [Remarks]
  • URL: http://www.h.u-tokyo.ac.jp/patient/depts/kogaku.html