The elucidation of role and molecular mechanism of LI-cadherin in gastrointestinal disease

• Project/Area Number: 19790473
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Gastroenterology
• Research Institution: Niigata University
• Principal Investigator: TAKAMURA Masaaki Niigata University, 医歯学総合病院, 医員 (20422602)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,700,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥600,000); Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2007: ¥1,100,000 (Direct Cost: ¥1,100,000)
• Keywords: LI-cadherin / 肝内胆管癌 / 脈管浸潤 / 予後因子 / siRNA / マイクロアレイ / MTF-1 / PlGF / PIGF

Research Abstract

肝内胆管癌症例でのLI-cadherin の臨床病理学的検討では、LI-cadherin 発現陰性例は分化度及び脈管浸潤と有意な相関を認め、独立した予後不良因子であった。培養細胞株にLI-cadherin siRNA を導入し、マイクロアレイを行った。LI-cadherin siRNA 導入株で発現上昇がみられた転写因子MTF-1 に注目し、下流制御分子の一つPlGF の発現上昇を確認した。以上、LI-cadherin の発現動態が肝内胆管癌において重要であることが示唆された。

Research Products

• [Journal Article] Adenylate cyclase-associated protein 1 overexpressed in pancreatic cancers is involved in cancer cell motility (2009)
  • Author(s): Yamazaki K, Takamura M, Masugi Y, Mori T, Du W, Hibi T, Hiraoka N, Ohta T, Ohki M, Hirohashi S, Sakamoto M
  • Journal Title: Laboratory Investigation 89 Pages: 425-432
  • Peer Reviewed
• [Journal Article] Adenylate cyclase-associated protein 1 overexpressed in pancreatic cancers is involved in cancer cell motility (2009)
  • Author(s): Yamazaki K
  • Journal Title: Laboratory Investigation 89 Pages: 425-432
  • Peer Reviewed
• [Journal Article] Sustained response to interferon-alpha plus ribavirin therapy for chronic hepatitis C is closely associated with increased dynamism of intrahepatic natural killer and natural killer T cells (2008)
  • Author(s): Yamagiwa S, Matsuda Y, Ichida T, Honda Y, Takamura M, Sugahara S, Ishikawa T, Ohkoshi S, Sato Y, Aoyagi Y
  • Journal Title: Hepatology Research 38 Pages: 664-672
  • Peer Reviewed
• [Journal Article] Temporal treatment with interferon-beta prevents hepatocellular carcinoma in hepatitis B virus X gene transgenic mice (2008)
  • Author(s): Yamazaki K, Suzuki K, Ohkoshi S, Yano M, Kurita S, Aoki YH, Toba K, Takamura MA, Yamagiwa S, Matsuda Y, Aoyagi Y
  • Journal Title: Journal of Hepatology 48 Pages: 255-265
  • Peer Reviewed
• [Journal Article] Temporal treatment with interferon-beta prevents hepatocellular carcinoma in hepatitis B virus X gene transgenic mice (2008)
  • Author(s): Yamazaki K
  • Journal Title: Journal of Hepatology 48 Pages: 255-265
  • Peer Reviewed
• [Journal Article] Sustained response to interferon-alpha plus ribavirin therapy for chronic hepatitis C is closely associated with increased dynamism of intrahepatic natural killer and natural killer T cells (2008)
  • Author(s): Yamagiwa S
  • Journal Title: Hepatology Research 38 Pages: 664-672
  • Peer Reviewed
• [Journal Article] Severe acute pancreatitis as an initial manifestation of primary hyperparathyroid adenoma in a pediatric patient (2007)
  • Author(s): Tuboi K, Takamura M, Sato Y, Yokoyama H, Takeuchi M, Igarashi M, Kondo D, Omori K, Ogawa A, Takeyama A, Koyama Y, Ajioka Y, Aoyagi Y
  • Journal Title: Pancreas 35 Pages: 100-101
  • Peer Reviewed
• [Journal Article] An inhibitor of c-Jun NH2-terminal kinase, SP600125, protects mice from D-galactosamine/lipopolysaccharideinduced hepatic failure by modulating BH3-only proteins (2007)
  • Author(s): Takamura M, Matsuda Y, Yamagiwa S, Tamura Y, Honda Y, Suzuki K, Ichida T, Aoyagi Y
  • Journal Title: Life Sciences 80 Pages: 1335-1344
  • Peer Reviewed
• [Journal Article] Decompensated lamivudine-resistant hepatitis B virus-related cirrhosis treated successfully with adefovir dipivoxil allowing surgery fo hepatocellular carcinoma (2007)
  • Author(s): Takamura M, Ichida T, Ohkoshi S, Tsubata S, Osaki A, Aoyagi T, Nomoto M, Uehara K, Terada H, Aoyagi Y
  • Journal Title: Internal Medicine 46 Pages: 367-371
  • Peer Reviewed
• [Journal Article] Altered expression of TLR homolog RP105 on monocytes hypersensitive to LPS in patients with primary biliary cirrhosis (2007)
  • Author(s): Honda Y, Yamagiwa S, Matsuda Y, Takamura M, Ichida T, Aoyagi Y
  • Journal Title: Journal of Hepatology 47 Pages: 404-411
  • Peer Reviewed
• [Journal Article] Tumor suppressor carcinoembryonic antigen-related cell adhesion molecule 1 potentates the anchorage-independent growth of human hepatoma HepG2 cells (2007)
  • Author(s): Hokari M, Matsuda Y, Wakai T, Shirai Y, Sato M, Tsuchiya A, Takamura M, Yamagiwa S, Suzuki K, Ohkoshi S, Ichida T, Kawachi H, Aoyagi Y
  • Journal Title: Life Sciences 81 Pages: 336-345
  • Peer Reviewed
• [Journal Article] An inhibitor of c-Jun NH2-terminal kinase, SP600125, protects mice from D-galactosamine/lipopolysaccharide-induced hepatic failure by modulating BH3-only proteins. (2007)
  • Author(s): Takamura M
  • Journal Title: Life Sciences 80 Pages: 1335-1344
  • Peer Reviewed
• [Journal Article] Decompensated lamivudine-resistant hepatitis B virus-related cirrhosis treated successfully with adefovir dipivoxil allowing surgery for hepatocellular carcinoma. (2007)
  • Author(s): Takamura M
  • Journal Title: Internal Medicine 46 Pages: 367-371
  • Peer Reviewed
• [Journal Article] Altered expression of TLR homolog RP105 on monocytes hypersensitive to LPS in patients with primary biliary cirrhosis. (2007)
  • Author(s): Honda Y
  • Journal Title: Journal of Hepatology 47 Pages: 404-411
  • Peer Reviewed
• [Journal Article] Severe acute pancreatitis as an initial manifestation of primary hyperparathyroid adenoma in a pediatric patient. (2007)
  • Author(s): Tsuboi K
  • Journal Title: Pancreas 35 Pages: 100-101
  • Peer Reviewed
• [Journal Article] Tumor suppressor carcinoembryonic antigen-related cell adhesion molecule 1 potentates the anchorage-independent growth of human hepatoma HepG2 cells. (2007)
  • Author(s): Hokari M
  • Journal Title: Life Sciences 81 Pages: 336-345
  • Peer Reviewed
• [Presentation] Expression of liver-intestine cadherin in intrahepatic cholangiocarcinoma : Its prognostic significance and relationship with vascular invasion (2008)
  • Author(s): 高村昌昭
  • Organizer: The 59th annual meeting of the american association for the study of liver diseases
  • Place of Presentation: Moscone West Convention Center (SAN FRANCISCO)
  • Year and Date: 2008-11-03
• [Presentation] Expression of liver-intestine cadherin in intrahepatic cholangiocarcinoma : Its prognostic significance and relationship with vascular invasion (Poster Session) (2008)
  • Author(s): 高村昌昭
  • Organizer: The 59th annual meeting of the american association for the study of liver diseases
  • Place of Presentation: SAN FRANCISCO Moscone West Convention Center
  • Year and Date: 2008-11-03
• [Presentation] 肝内胆管癌におけるLiver-intestine (LI)-cadherin 発現動態とその意義 (2008)
  • Author(s): 高村昌昭
  • Organizer: 第40回日本臨床分子形態学会
  • Place of Presentation: 福岡国際会議場(福岡県福岡市)
  • Year and Date: 2008-10-03
• [Presentation] 肝内胆管癌におけるLiver-intestine(LI)-cadherin発現動態とその意義(シンポジウム) (2008)
  • Author(s): 高村昌昭
  • Organizer: 第40回日本臨床分子形態学会
  • Place of Presentation: 福岡県福岡市福岡国際会議場
  • Year and Date: 2008-10-03
• [Presentation] 肝内胆管癌におけるLiver-intestine (LI)-cadherin の発現の検討 (2008)
  • Author(s): 高村昌昭
  • Organizer: 第44回日本肝臓学会総会
  • Place of Presentation: 愛媛県県民文化会館(愛媛県松山市)
  • Year and Date: 2008-06-05
• [Presentation] 肝内胆管癌におけるLiver-intestine(LI)-cadherinの発現の検討(会長奨励賞) (2008)
  • Author(s): 高村昌昭
  • Organizer: 第44回日本肝臓学会総会
  • Place of Presentation: 愛媛県松山市愛媛県県民文化会館
  • Year and Date: 2008-06-05