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The elucidation of role and molecular mechanism of LI-cadherin in gastrointestinal disease

Research Project

Project/Area Number 19790473
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Gastroenterology
Research InstitutionNiigata University

Principal Investigator

TAKAMURA Masaaki  Niigata University, 医歯学総合病院, 医員 (20422602)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,700,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥600,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2007: ¥1,100,000 (Direct Cost: ¥1,100,000)
KeywordsLI-cadherin / 肝内胆管癌 / 脈管浸潤 / 予後因子 / siRNA / マイクロアレイ / MTF-1 / PlGF / PIGF
Research Abstract

肝内胆管癌症例でのLI-cadherin の臨床病理学的検討では、LI-cadherin 発現陰性例は分化度及び脈管浸潤と有意な相関を認め、独立した予後不良因子であった。培養細胞株にLI-cadherin siRNA を導入し、マイクロアレイを行った。LI-cadherin siRNA 導入株で発現上昇がみられた転写因子MTF-1 に注目し、下流制御分子の一つPlGF の発現上昇を確認した。以上、LI-cadherin の発現動態が肝内胆管癌において重要であることが示唆された。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (22 results)

All 2009 2008 2007

All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (6 results)

  • [Journal Article] Adenylate cyclase-associated protein 1 overexpressed in pancreatic cancers is involved in cancer cell motility2009

    • Author(s)
      Yamazaki K, Takamura M, Masugi Y, Mori T, Du W, Hibi T, Hiraoka N, Ohta T, Ohki M, Hirohashi S, Sakamoto M
    • Journal Title

      Laboratory Investigation 89

      Pages: 425-432

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adenylate cyclase-associated protein 1 overexpressed in pancreatic cancers is involved in cancer cell motility2009

    • Author(s)
      Yamazaki K
    • Journal Title

      Laboratory Investigation 89

      Pages: 425-432

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sustained response to interferon-alpha plus ribavirin therapy for chronic hepatitis C is closely associated with increased dynamism of intrahepatic natural killer and natural killer T cells2008

    • Author(s)
      Yamagiwa S, Matsuda Y, Ichida T, Honda Y, Takamura M, Sugahara S, Ishikawa T, Ohkoshi S, Sato Y, Aoyagi Y
    • Journal Title

      Hepatology Research 38

      Pages: 664-672

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Temporal treatment with interferon-beta prevents hepatocellular carcinoma in hepatitis B virus X gene transgenic mice2008

    • Author(s)
      Yamazaki K, Suzuki K, Ohkoshi S, Yano M, Kurita S, Aoki YH, Toba K, Takamura MA, Yamagiwa S, Matsuda Y, Aoyagi Y
    • Journal Title

      Journal of Hepatology 48

      Pages: 255-265

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Temporal treatment with interferon-beta prevents hepatocellular carcinoma in hepatitis B virus X gene transgenic mice2008

    • Author(s)
      Yamazaki K
    • Journal Title

      Journal of Hepatology 48

      Pages: 255-265

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sustained response to interferon-alpha plus ribavirin therapy for chronic hepatitis C is closely associated with increased dynamism of intrahepatic natural killer and natural killer T cells2008

    • Author(s)
      Yamagiwa S
    • Journal Title

      Hepatology Research 38

      Pages: 664-672

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Severe acute pancreatitis as an initial manifestation of primary hyperparathyroid adenoma in a pediatric patient2007

    • Author(s)
      Tuboi K, Takamura M, Sato Y, Yokoyama H, Takeuchi M, Igarashi M, Kondo D, Omori K, Ogawa A, Takeyama A, Koyama Y, Ajioka Y, Aoyagi Y
    • Journal Title

      Pancreas 35

      Pages: 100-101

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] An inhibitor of c-Jun NH2-terminal kinase, SP600125, protects mice from D-galactosamine/lipopolysaccharideinduced hepatic failure by modulating BH3-only proteins2007

    • Author(s)
      Takamura M, Matsuda Y, Yamagiwa S, Tamura Y, Honda Y, Suzuki K, Ichida T, Aoyagi Y
    • Journal Title

      Life Sciences 80

      Pages: 1335-1344

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Decompensated lamivudine-resistant hepatitis B virus-related cirrhosis treated successfully with adefovir dipivoxil allowing surgery fo hepatocellular carcinoma2007

    • Author(s)
      Takamura M, Ichida T, Ohkoshi S, Tsubata S, Osaki A, Aoyagi T, Nomoto M, Uehara K, Terada H, Aoyagi Y
    • Journal Title

      Internal Medicine 46

      Pages: 367-371

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Altered expression of TLR homolog RP105 on monocytes hypersensitive to LPS in patients with primary biliary cirrhosis2007

    • Author(s)
      Honda Y, Yamagiwa S, Matsuda Y, Takamura M, Ichida T, Aoyagi Y
    • Journal Title

      Journal of Hepatology 47

      Pages: 404-411

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tumor suppressor carcinoembryonic antigen-related cell adhesion molecule 1 potentates the anchorage-independent growth of human hepatoma HepG2 cells2007

    • Author(s)
      Hokari M, Matsuda Y, Wakai T, Shirai Y, Sato M, Tsuchiya A, Takamura M, Yamagiwa S, Suzuki K, Ohkoshi S, Ichida T, Kawachi H, Aoyagi Y
    • Journal Title

      Life Sciences 81

      Pages: 336-345

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] An inhibitor of c-Jun NH2-terminal kinase, SP600125, protects mice from D-galactosamine/lipopolysaccharide-induced hepatic failure by modulating BH3-only proteins.2007

    • Author(s)
      Takamura M
    • Journal Title

      Life Sciences 80

      Pages: 1335-1344

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decompensated lamivudine-resistant hepatitis B virus-related cirrhosis treated successfully with adefovir dipivoxil allowing surgery for hepatocellular carcinoma.2007

    • Author(s)
      Takamura M
    • Journal Title

      Internal Medicine 46

      Pages: 367-371

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Altered expression of TLR homolog RP105 on monocytes hypersensitive to LPS in patients with primary biliary cirrhosis.2007

    • Author(s)
      Honda Y
    • Journal Title

      Journal of Hepatology 47

      Pages: 404-411

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Severe acute pancreatitis as an initial manifestation of primary hyperparathyroid adenoma in a pediatric patient.2007

    • Author(s)
      Tsuboi K
    • Journal Title

      Pancreas 35

      Pages: 100-101

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tumor suppressor carcinoembryonic antigen-related cell adhesion molecule 1 potentates the anchorage-independent growth of human hepatoma HepG2 cells.2007

    • Author(s)
      Hokari M
    • Journal Title

      Life Sciences 81

      Pages: 336-345

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Expression of liver-intestine cadherin in intrahepatic cholangiocarcinoma : Its prognostic significance and relationship with vascular invasion2008

    • Author(s)
      高村昌昭
    • Organizer
      The 59th annual meeting of the american association for the study of liver diseases
    • Place of Presentation
      Moscone West Convention Center (SAN FRANCISCO)
    • Year and Date
      2008-11-03
    • Related Report
      2008 Final Research Report
  • [Presentation] Expression of liver-intestine cadherin in intrahepatic cholangiocarcinoma : Its prognostic significance and relationship with vascular invasion (Poster Session)2008

    • Author(s)
      高村昌昭
    • Organizer
      The 59th annual meeting of the american association for the study of liver diseases
    • Place of Presentation
      SAN FRANCISCO Moscone West Convention Center
    • Year and Date
      2008-11-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] 肝内胆管癌におけるLiver-intestine (LI)-cadherin 発現動態とその意義2008

    • Author(s)
      高村昌昭
    • Organizer
      第40回日本臨床分子形態学会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2008-10-03
    • Related Report
      2008 Final Research Report
  • [Presentation] 肝内胆管癌におけるLiver-intestine(LI)-cadherin発現動態とその意義(シンポジウム)2008

    • Author(s)
      高村昌昭
    • Organizer
      第40回日本臨床分子形態学会
    • Place of Presentation
      福岡県福岡市福岡国際会議場
    • Year and Date
      2008-10-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] 肝内胆管癌におけるLiver-intestine (LI)-cadherin の発現の検討2008

    • Author(s)
      高村昌昭
    • Organizer
      第44回日本肝臓学会総会
    • Place of Presentation
      愛媛県県民文化会館(愛媛県松山市)
    • Year and Date
      2008-06-05
    • Related Report
      2008 Final Research Report
  • [Presentation] 肝内胆管癌におけるLiver-intestine(LI)-cadherinの発現の検討(会長奨励賞)2008

    • Author(s)
      高村昌昭
    • Organizer
      第44回日本肝臓学会総会
    • Place of Presentation
      愛媛県松山市愛媛県県民文化会館
    • Year and Date
      2008-06-05
    • Related Report
      2008 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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