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Role of sphingolipids on hepatocyte apoptosis of chronic liver injury

Research Project

Project/Area Number 19790478
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Gastroenterology
Research InstitutionGifu University

Principal Investigator

OSAWA Yosuke  Gifu University, 大学院医学系研究科, 助教授 (60447787)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,750,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywords慢性肝障害 / アポトーシス / クッパー細胞 / 肝線維化 / スフィンゴミエリナーゼ / 肝再生 / スフィンゴ脂質
Research Abstract

胆管結紮により誘導される慢性肝障害では、クッパー細胞の活性化により障害肝に残存する肝細胞がAKT 活性化を介した抗アポトーシス状態を獲得する。クッパー細胞は、肝障害に対し抑制的に作用する役割を有する。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (18 results)

All 2009 2008 2007

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (8 results)

  • [Journal Article] Sphingosine kinase isoforms regulate oxaliplatin sensitivity of human colon cancer cells through ceramide accumulation and AKT activtion2009

    • Author(s)
      Nemoto, S., Nakamura, M., Osawa, Y., Kono, S., Itoh, Y., Okano, Y., Murate, T., Hara, A., Ueda, H., Nozawa, Y. , Banno, Y.
    • Journal Title

      J Biol Chem (in print)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antiapoptotic effect of c-Jun N-terminal Kinase-1 through Mcl-1 stabilization in TNF-induced hepatocyte apoptosis2009

    • Author(s)
      Kodama, Y., Taura, K., Miura, K., Schnabl, B., Osawa, Y. and Brenner, D. A.
    • Journal Title

      Gastroenterology 136

      Pages: 1423-1434

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cyclooxygenase-2: its paradoxical roles in liver inflammation and fibrosis2008

    • Author(s)
      Osawa, Y. and Nagaki, M.
    • Journal Title

      Hepatol Res 38

      Pages: 772-774

    • NAID

      10021945849

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cyclooxygenase-2 : its paradoxical roles in liver inflammation and fibrosis2008

    • Author(s)
      Osawa Y, Nagaki M
    • Journal Title

      Hepatology Research 38

      Pages: 123-125

    • NAID

      10021945849

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TLR4 enhances TGF-beta signaling and hepatic fibrosis2007

    • Author(s)
      Seki, E., De Minicis, S., Osterreicher, C. H., Kluwe, J., Osawa, Y., Brenner, D. A., Schwabe, R. F.
    • Journal Title

      Nat Med 13

      Pages: 1324-1332

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epimorphin, a morphogenic protein, induces proteases in rodent hepatocytes through NF-kappaB2007

    • Author(s)
      Miura, K., Yoshino, R., Hirai, Y., Goto, T., Ohshima, S., Mikami, K., Yoneyama, K., Watanabe, D., Sato, M., Senoo, H., Kodama, Y., Osawa, Y., Brenner, D. A., Watanabe, S.
    • Journal Title

      J Hepatol 47

      Pages: 834-843

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alpha-1 antitrypsin Z protein (PiZ) increases hepatic fibrosis in a murine model of cholestasis2007

    • Author(s)
      Mencin, A., Seki, E., Osawa, Y., Kodama, Y., De Minicis, S., Knowles, M. and Brenner, D. A.
    • Journal Title

      Hepatology 46

      Pages: 1443-1452

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Forkhead Transcription Factor FoxO1 Regulates Proliferation and Transdifferentiation of Hepatic Stellate Cells2007

    • Author(s)
      Adachi, M., Osawa, Y., Uchinami, H., Kitamura, T., Accili, D. and Brenner, D. A.
    • Journal Title

      Gastroenterology 132

      Pages: 1434-1446

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Forkhead Transcription Factor FoxO1 Regulates Proliferation and Transdifferentiation of Hepatic Stellate Cells2007

    • Author(s)
      Adachi M, Osawa Y
    • Journal Title

      Gastroenterology 132

      Pages: 1434-46

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alpha-1 antitrypsin Z protein (PiZ)increases hepatic fibrosis in a mu rine model of cholestasis2007

    • Author(s)
      Mencin A, Osawa Y
    • Journal Title

      Hepatology 46

      Pages: 1443-1452

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Anti-apoptotic effects against TNF-alpha treatment in bile duct ligated mouse liver2008

    • Author(s)
      Osawa Y
    • Organizer
      Digestive Disease Week (DDW) 2008
    • Place of Presentation
      サンディエゴ
    • Year and Date
      2008-05-22
    • Related Report
      2008 Final Research Report
  • [Presentation] Anti-apoptotic effects against TNF-alpha treatment in bile duct ligated mouse liver2008

    • Author(s)
      Osawa Y
    • Organizer
      Digestive Disease Week (DDW) 2008
    • Place of Presentation
      米国サンディエゴ
    • Year and Date
      2008-05-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] 肝星細胞におけるコラーゲン産生にかかわるfocal およびsystemic factor の検討2007

    • Author(s)
      大澤 陽介
    • Organizer
      第11 回日本肝臓学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2007-10-18
    • Related Report
      2008 Final Research Report
  • [Presentation] 肝星細胞におけるコラーゲン産生にかかわるfocalおよびsystemic factorの検計2007

    • Author(s)
      大澤 陽介
    • Organizer
      第11回日本肝臓学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2007-10-18
    • Related Report
      2007 Annual Research Report
  • [Presentation] 胆管結紮により誘導された慢性肝障害マウスモデルにおける抗アポトーシス獲得機序2007

    • Author(s)
      大澤 陽介
    • Organizer
      第18 回The Meeting of Liver and Immunology
    • Place of Presentation
      京都
    • Year and Date
      2007-09-01
    • Related Report
      2008 Final Research Report
  • [Presentation] 胆管結紮により誘導された慢性肝障害マウスモデルにおける抗アポトーシス獲得機序2007

    • Author(s)
      大澤 陽介
    • Organizer
      第18回The Meeting of Liver andImmunology
    • Place of Presentation
      京都
    • Year and Date
      2007-09-01
    • Related Report
      2007 Annual Research Report
  • [Presentation] Systemic Mediators Induce Fibrogenic Effects in Normal Liver after Partial Bile Duct Ligation2007

    • Author(s)
      Osawa Y
    • Organizer
      Digestive Disease Week (DDW) 2007
    • Place of Presentation
      ワシントンDC
    • Year and Date
      2007-05-22
    • Related Report
      2008 Final Research Report
  • [Presentation] Systemic Mediators Induce Fibrogenic Effects in Normal Liver after Partial Bile Duct Ligation2007

    • Author(s)
      Osawa Y
    • Organizer
      Digestive Disease Week(DDW)2007
    • Place of Presentation
      ワシントンDC
    • Year and Date
      2007-05-22
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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