Development of a new therapeutic strategy regulating Delta-Jagged interaction on dendritic cells for inflammatory bowel disease
Project/Area Number |
19790483
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Gastroenterology
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Research Institution | Kyoto University |
Principal Investigator |
UZA Norimitsu Kyoto University, 医学研究科, 医員 (30447958)
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Project Period (FY) |
2007 – 2008
|
Project Status |
Completed (Fiscal Year 2008)
|
Budget Amount *help |
¥3,420,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥1,600,000 (Direct Cost: ¥1,600,000)
|
Keywords | 炎症性腸疾患 / 樹状細胞 / Notch シグナル / Delta / Jagged-1 / Notchシグナル |
Research Abstract |
樹状細胞のDelta-Jaggedの制御を応用した炎症性腸疾患に対する治療開発は未だに行われていない。本研究の結果より、Jagged-1を強制発現させた樹状細胞の移入によって実験的腸炎モデルにおける腸炎が有意に改善することが示された。Jagged-1強発現樹状細胞は制御性T細胞を誘導し腸炎の改善効果につながるものと考えられた。以上の結果から樹状細胞に発現するDelta, jaggedの制御が炎症性腸疾患患者に対する新たな治療法となるものと期待される。
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] Blockade of CXCL12/CXCR4 axis ameliorates murine experimental colitis2008
Author(s)
Mikami S, Nakase H, Yamamoto S, Takeda Y, Yoshino T, Kasahara K, Ueno S, Uza N, Oishi S, Fujii N, Nagasawa T, Chiba T.
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Journal Title
J Pharmacol Exp Ther. 327
Pages: 383-92
Related Report
Peer Reviewed
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[Journal Article] Long-term effect of tacrolimus therapy in patients with refractory ulcerative colitis2008
Author(s)
Yamamoto S, Nakase H, Mikami S, Inoue S, Yoshino T, Takeda Y, Kasahara K, Ueno S, Uza N, Kitamura H, Tamaki H, Matsuura M, Inui K, Chiba T.
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Journal Title
Aliment Pharmacol Ther. 28
Pages: 589-97
Related Report
Peer Reviewed
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[Journal Article] Usefulness of quantitative real-time PCR assay for early detection of cytomegalovirus infection in patients with ulcerative colitis refractory to immunosuppressive therapies2007
Author(s)
Yoshino T, Nakase H, Ueno S, Uza N, Inoue S, Mikami S, Matsuura M, Ohmori K, Sakurai T, Nagayama S, Hasegawa S, Sakai Y, Chiba T.
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Journal Title
Inflamm Bowel Dis. 13
Pages: 1516-21
Related Report
Peer Reviewed
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[Journal Article] Rescue therapy with tacrolimus for a patient with severe ulcerative colitis refractory to combination leukocytapheresis and high-dose corticosteroid therapy2007
Author(s)
Nakase H, Mikami S, Matsuura M, Ueno S, Uza N, Inoue S, Kitamura H, Kasahara K, Yoshino T, Takeda Y, Chiba T.
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Journal Title
Intern Med. 46
Pages: 717-20
NAID
Related Report
Peer Reviewed
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