Analysis of the PPAR gamma interaction in pancreatic carcinoma

• Project/Area Number: 19790489
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Gastroenterology
• Research Institution: Yokohama City University
• Principal Investigator: TAKAHASHI Hirokazu Yokohama City University, 附属病院, 助教 (70438159)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,780,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
• Keywords: 膵癌 / PPARγ / 浸潤 / 細胞運動 / 転移

Research Abstract

核内受容体スーパーファミリーであるPeroxisome Proliferator-Activated receptor (PPAR)γリガンドの膵癌細胞に対する作用解析を目的とした.膵癌細胞においてPPARγリガンドは細胞運動,転移能を減少させ,マウスモデルでは転移巣を減少させた.膵癌のみならず大腸癌,乳癌,前立腺癌などにおいても抗腫瘍効果が示唆されており,今後臨床応用へ向け既存の抗がん剤との併用療法などの無作為化比較試験を行う必要がある.

Research Products

• [Journal Article] Chemotherapeutic treatment of priapism in metastatic rectal cancer (2008)
  • Author(s): Kitai Y, Takahashi H, Goto A, Iida H, Mawatari H, Fujita K, Yoneda M, Inamori M, Abe Y, Kobayashi N, Kirikoshi H, Kubota K, Saito S, Nakajima A.
  • Journal Title: Cace Rep Gastroenterol. 2 Pages: 505-508
• [Journal Article] Gastric Inflammatory Fibroid Polyp Treated by Endoscopic Submucosal Dissection. (2008)
  • Author(s): Hattori Y, Kobayashi S, Takahashi H, Yoneda M, Inamori M, Abe Y, Kubota K, Saito S, Nakajima A.
  • Journal Title: Cace Rep Gastroenterol. 2 Pages: 283-286
• [Journal Article] Gastric Varices with Remarkable Collateral Veins in Valpronic Acid-Induced Chronic Pancreatitis. (2008)
  • Author(s): Hattori Y, Higurashi T, Takahashi H, Inamori M, Abe Y, Rino Y, Nakajima, A.
  • Journal Title: Cace Rep Gastroenterol. 2 Pages: 279-282
• [Journal Article] Education and imaging. Gastrointestinal: ascariasis. (2008)
  • Author(s): Suzuki A, Yabushita Y, Takahashi H, Inamori M, Nakao S, Suzuki K, Iida H, Endo H, Akiyama T, Ikeda T, Sakamoto Y, Fujita K, Yoneda M, Goto A, Abe Y, Kirikoshi H, Kobayashi N, Kubota K, Saito S, Nakajima A.
  • Journal Title: J Gastroenterol Hepatol. 23 Pages: 1770-1770
• [Journal Article] Education and imaging. Gastrointestinal: mantle cell lymphoma diagnosed by balloon enteroscopy. (2008)
  • Author(s): Yumori A, Okubo H, Takahashi H, Iida H, Mawatari H, Yoneda M, Inamori M, Abe Y, Kobayashi N, Kirikoshi H, Kubota K, Saito S, Nakajima A.
  • Journal Title: J Gastroenterol Hepatol. 23 Pages: 1623-1623
• [Journal Article] Anaplastic carcinoma of the pancreas producing granulocyte-colony stimulating factor : a case report. (2008)
  • Author(s): Nakajima A, Takahashi H, Inamori M, Abe Y, Kobayashi N, Kubota K, Yamanaka S.
  • Journal Title: J Med Case Reports. 2 Pages: 391-391
• [Journal Article] Inhibition of Peroxisome Proliferator-Activated Receptor gamma Promotes Tumorigenesis Through Activation of the beta-Catenin / T Cell Factor (TCF) Pathway in the Mouse Intestine. (2008)
  • Author(s): Fujisawa T, Sugiyama M, Tomimoto A, Wada K, Endo H, Takahashi H, Yoneda K, Yoneda M, Inamori M, Saito S, Terauchi Y, Kadowaki T, Tsuchiya N, Nakagama H, Nakajima A.
  • Journal Title: J Pharmacol Sci. 108 Pages: 535-544
  • NAID: 130000075870
• [Journal Article] Inhibition of peroxisome proliferator-activated receptor gamma activity suppresses pancreatic cancer cell motility. (2008)
  • Author(s): Nakajima A, Tomimoto A, Fujita K, Sugiyama M, Takahashi H, Ikeda I, Hosono K, Endo H, Yoneda K, Iida H, Inamori M, Kubota K, Saito S, Nakajima N, Wada K, Nagashima Y, Nakagama H.
  • Journal Title: Cancer Sci. 99 Pages: 1892-1900
• [Journal Article] Metformin suppresses intestinal polyp growth in Apc(Min/+) mice. (2008)
  • Author(s): Tomimoto A, Endo H, Sugiyama M, Fujisawa T, Hosono K, Takahashi H, Nakajima N, Nagashima Y, Wada K, Nakagama H, Nakajima A.
  • Journal Title: Cancer Sci. 99 Pages: 2136-2141
  • NAID: 10024012700
• [Journal Article] Expression of adiponectin receptors, AdipoR1 and AdipoR2, in normal colon epithelium and colon cancer tissue. (2008)
  • Author(s): Yoneda K, Tomimoto A, Endo H, Iida H, Sugiyama M, Takahashi H, Mawatari H, Nozaki Y, Fujita K, Yoneda M, Inamori M, Nakajima N, Wada K, Nagashima Y, Nakagama H, Uozaki H, Fukayama M, Nakajima A.
  • Journal Title: Oncol Rep. 20 Pages: 479-483
• [Journal Article] Adiponectin Suppresses Colorectal Carcinogenesis under the High-fat Diet Condition. (2008)
  • Author(s): Fujisawa T, Endo H, Tomimoto A, Sugiyama M, Takahashi H, Saito S, Inamori M, Nakajima N, Watanabe M, Kubota N, Yamauchi T, Kadowaki T, Wada K, Nakagama H, Nakajima A.
  • Journal Title: Gut. 57 Pages: 1531-1538
• [Journal Article] Peroxisome proliferator-activated receptor gamma (PPARgamma) suppresses colonic epithelial cell turnover and colon carcinogenesis through inhibition of the beta-catenin/T cell factor (TCF) pathway (2008)
  • Author(s): Fujisawa T
  • Journal Title: J Pharmacol Sci 106 Pages: 627-638
  • Peer Reviewed
• [Journal Article] Expression of adiponectin receptors, AdipoRl and AdipoR2, in norma1 colon epithelium and colon cancer tissue (2008)
  • Author(s): Yoneda K
  • Journal Title: Oncol Rep 20 Pages: 479-483
  • Peer Reviewed
• [Journal Article] Metformin suppresses intestinal polyp growth in Apc(Min/+) mice (2008)
  • Author(s): Tomimoto A
  • Journal Title: Cancer Sci 99 Pages: 2136-2141
  • Peer Reviewed
• [Journal Article] Inhibition of peroxisome proliferator-activated receptor gamma activity suppresses pancreatic cancer cell motility (2008)
  • Author(s): Nakajima A
  • Journal Title: Cancer Sci 99 Pages: 1892-1900
  • Peer Reviewed
• [Journal Article] Inhibition of Peroxisome Proliferator-Activated Receptor gamma Promotes Tumorigenesis Through Activation of the beta-Catenin / T Cell Factor (TCF) Pathway in the Mouse Intestine (2008)
  • Author(s): Fujisawa T
  • Journal Title: J Pharmacol Sci 108 Pages: 535-544
  • Peer Reviewed
• [Journal Article] PPARgamma inhibitors reduce tubulin protein levels by a PPARgamma,PPARdelta and proteasome-independent mechanism,resulting in cell cycle arrest,apoptosis and reduced metastasis of colorectal carcinom a cells (2007)
  • Author(s): Schaefer KL
  • Journal Title: Int J Cancer 120 Pages: 702-713
  • Peer Reviewed
• [Journal Article] Blockade of leukotriene B4 signaling pathway induces apoptosis and suppresses cell proliferation in colon cancer (2007)
  • Author(s): Ihara A
  • Journal Title: J Pharmacol Sci 103 Pages: 24-32
  • Peer Reviewed
• [Journal Article] Life Style-Related Diseases of the Digestive System:Colorectal Cancer as a Life Style-Related Disease:from Carcinogenesis to Medical Treatment (2007)
  • Author(s): Takahashi H
  • Journal Title: J Pharmacol Sci 105 Pages: 129-132
  • Peer Reviewed
• [Journal Article] 5-Aminosalicylic Acid Given in the Remission Stage of Colitis Suppr esses Colitis-Associated Cancer in a Mouse Colitis Model (2007)
  • Author(s): Ikeda I
  • Journal Title: Chit Cancer Res 13 Pages: 6527-6531
  • Peer Reviewed
• [Presentation] Abnormal glucose tolerance and plasma IGF-1 correlate with dysplastic aberrant crypt foci in colorectal tumor free male (2008)
  • Author(s): Takahashi H, Hosono K, Yoneda K, Endo H, Nozaki Y, Akiyama T, Fujita K, Yoneda M, Inamori M, Abe Y, Saito S, Nakajima A
  • Organizer: 2008 JCA
  • Place of Presentation: Nagoya
  • Year and Date: 2008-10-29
• [Presentation] 造影エコーが診断に有用であった 門脈血栓症の1例 (2008)
  • Author(s): 高橋宏和, 桐越博之, 米田正人, 稲森正彦, 阿部泰伸,小林規俊, 窪田賢輔, 斉藤聡, 上野規男, 中島淳
  • Organizer: 日本超音波医学会関東甲信越地方会第20回学術集会
  • Place of Presentation: 東京
  • Year and Date: 2008-10-25
• [Presentation] Abdominal surgery affects small bowel transit time and completeness of capsule endoscopy (2008)
  • Author(s): Hosono K
  • Organizer: 2008 16^<th> UEGW
  • Place of Presentation: Vienna
  • Year and Date: 2008-10-21
• [Presentation] Correlation of the plasma level of insulin-like growth factor-1 (IGF-1) with the number of aberrant crypt foci in men (2008)
  • Author(s): Takahashi H, Hosono K, Endo H, Yoneda K, Mawatari H, Fujita K, Yoneda M, Abe Y, Inamori M, Kobayashi N, Kirikoshi H, Kubota K, Saito S, Nakajima A
  • Organizer: 2008 16th UEGW
  • Place of Presentation: Vienna
  • Year and Date: 2008-10-20
• [Presentation] Correlation of the plasma level of insulin-like growth factor-1 (IGF-1) with the number of aberrant crypt foci in men (2008)
  • Author(s): Hirokazu Takahashi
  • Organizer: 2008 16^<th> UEGW
  • Place of Presentation: Vienna
  • Year and Date: 2008-10-20
• [Presentation] 内臓脂肪およびアディポネクチンと大腸発癌における性差パネルディスカッション4性差からみた消化器疾患の病態と予後 (2008)
  • Author(s): 高橋宏和,細野邦広,中島淳
  • Organizer: 第50回日本消化器病学会大会
  • Place of Presentation: 東京
  • Year and Date: 2008-10-01
• [Presentation] 直腸癌に合併した持続勃起症に対して化学療法が著効した1例 (2008)
  • Author(s): 高橋宏和,馬渡弘典,加藤真吾,内山崇,飯田洋,野崎雄一,遠藤宏樹,米田恭子,秋山智之,藤田浩司,米田正人,後藤歩,廣川智,稲森正彦,阿部泰伸,小林規俊,桐越博之,窪田賢輔,斉藤聡,上野規男,中島淳
  • Organizer: 第301回日本消化器病学会関東支部例会
  • Place of Presentation: 東京
  • Year and Date: 2008-09-06
• [Presentation] Visceral fat obesity and abnormal glucose tolerance correlate with dysplastic aberrant crypt foci in colorectal tumor free male (oral session) (2008)
  • Author(s): Hirokazu Takahashi, Kyoko Yoneda, Hiroki Endo, Hiroshi Iida, Tomoyuki Akiyama, Yasunobu Abe, Masahiko Inamori, Atsushi Nakajima
  • Organizer: 2008 DDW
  • Place of Presentation: San Diego
  • Year and Date: 2008-05-18
• [Presentation] Visceral fat obesity and abnormal glucose tolerance correlate with dysplastic aberrant crypt foci in colorectal tumor free male (2008)
  • Author(s): Hirokazu Takahashi
  • Organizer: 2008 DDW
  • Place of Presentation: San Diego
  • Year and Date: 2008-05-18
• [Presentation] Adiponectin suppresses colorectal carcinogenesis induced by high-fat diet via AMP protein kinase (2008)
  • Author(s): Fujisawa N
  • Organizer: 2008 DDW
  • Place of Presentation: San Diego
  • Year and Date: 2008-05-18
• [Presentation] Metformin suppresses the colorectal carcinogenesis via activating P protein kinase (2008)
  • Author(s): Suzuki K
  • Organizer: 2008 DDW
  • Place of Presentation: San Diego
  • Year and Date: 2008-05-18
• [Presentation] Adipocytokines and dysplastic aberrant crypt foci (2007)
  • Author(s): Hirokazu Takahashi
  • Organizer: 6th Annual AACR International Conference F rontiers in Cancer Prevention Research
  • Place of Presentation: Philadelphia
  • Year and Date: 2007-12-16
• [Presentation] Adiponectin and dysplastic aberrant crypt foci (2007)
  • Author(s): Takahashi H
  • Organizer: 2007 JCA
  • Place of Presentation: Yokohama
  • Year and Date: 2007-10-03
• [Presentation] Clinical signficance of Cystatin SN as a novel biomarker for colorect al cancer (2007)
  • Author(s): Kyoko Yonemitsu
  • Organizer: DDW 2007
  • Place of Presentation: Washington DC
  • Year and Date: 2007-05-13
• [Presentation] Visceral fat obesity increase dysplastic aberrant cript foci (2007)
  • Author(s): Hirokazu Takahashi
  • Organizer: 100th AACR Annual Meeting 2007
  • Place of Presentation: Los Angeles
  • Year and Date: 2007-04-17
• [Presentation] PPARg attenuates cancer cell migration and invasion through activation of small GTPase protein,cdc42/Rac-1 in Pancreatic Cancer (2007)
  • Author(s): Ayako Tomimoto
  • Organizer: 100th AACR Annual Meeting 2007
  • Place of Presentation: Los Angeles
  • Year and Date: 2007-04-15
• [Book] MMJ.抗炎症薬による結腸直腸がんの1次予防 (2007)
  • Author(s): 高橋 宏和
  • Total Pages: 4
  • Publisher: 毎日新聞社
• [Book] 【内臓肥満と消化器疾患】内臓肥満と消化器疾患(消化管)
  • Author(s): 稲森正彦,秋山智之,高橋宏和,阿部泰伸,中島淳
  • Publisher: 日本消化器病学会雑誌
• [Book] 早期胃癌の内視鏡的治療レーザー治療(適応と成績,合併症)
  • Author(s): 野崎雄一,阿部泰伸,藤田浩司,米田正人,飯田洋,馬渡弘典,遠藤宏樹,秋山智之,米田恭子,高橋宏和,小林規俊,桐越博之,稲森正彦,窪田賢輔,斉藤聡,川口実,中島淳
  • Publisher: 消化器外科
• [Book] 切除不能膵癌に対するGemcitabine単独化学療法の適切な治療効果判定法についての検討
  • Author(s): 小林規俊,藤田浩司,藤沢聡郎,高橋宏和,米田正人,阿部泰伸,稲森正彦,桐越博之,窪田賢輔,斉藤聡,中島淳
  • Publisher: 癌と化学療法