Dendritic cell-based peptide vaccine against HCC

• Project/Area Number: 19790496
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Gastroenterology
• Research Institution: Showa University
• Principal Investigator: EGUCHI Junichi Showa University, 医学部, 助教 (00384371)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,830,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥630,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥1,100,000 (Direct Cost: ¥1,100,000)
• Keywords: 免疫学 / 内科 / 癌 / 肝細胞癌

Research Abstract

HCC is usually associated with cirrhosis and often recurs even after complete treatment of the tumors in the remaining part of the cirrhotic liver. Thus, there is a strong need for the development of a new intervention therapy that suppresses the occurrence or recurrence of HCC effectively and that has fewer side effects. Immunotherapy may be such a treatment and may be applicable to the clinical treatment of HCC. Restricted and high-level expression of Glypican-3 in a majority of human HCC makes this protein an attractive vaccine target. Here we described the identification of the new Glypican-3 peptide as a HLA restricted CTL epitope.

Research Products

• [Journal Article] Strong CD8(+) T-cell responses against tumor-associated antigens prolong the recurrence-free interval after tumor treatment in patients with HCC (2010)
  • Author(s): Hiroishi K., Eguchi J. Baba T., Shimazaki T., Ishii S., Hiraide A., Sakaki M., Doi H., Uozumi S., Omori R., Matsumura T., Yanagawa T., Ito T., Imawari M
  • Journal Title: Journal of Gastroenterology 45(4) Pages: 451-458
  • Peer Reviewed
• [Journal Article] Strong CD8(+) T-cell responses against tumor-associated antigens prolong the recurrence-free interval after tumor treatment in patients with HCC. (2010)
  • Author(s): Kazumasa Hiroishi., 他
  • Journal Title: Journal of Gastroenterology 45 Pages: 451-458
  • Peer Reviewed
• [Journal Article] Magnitude of CD8 T-cell responses against hepatitis C virus and severity of hepatitis do not necessarily determine outcomes in acute hepatitis C virus infection (2009)
  • Author(s): Doi H., Hiroishi K., Shimazaki T., Eguchi J., Baba T., Ito T., Matsumura T., Nozawa H., Morikawa K., Ishii S., Hiraide A., Sakaki M., Imawari M
  • Journal Title: Hepatology Research 39(3) Pages: 256-265
  • NAID: 10025324889
  • Peer Reviewed
• [Journal Article] Magnitude of CD8 T-cell responses against HCV and severity of hepatitis do not necessarily determine outcomes in acute HCV infection (2009)
  • Author(s): Hiroyoshi Doi
  • Journal Title: Hepatology Research 39巻・3号 Pages: 256-265
  • Peer Reviewed
• [Journal Article] Dendritic cells stimulated with cytidine-phosphate-guanosine oligodeoxynucleotides and interferon-alpha-expressing tumor cells effectively reduce outgrowth of established tumors in vivo (2008)
  • Author(s): Hiraide A., Hiroishi K., Eguchi J. Ishii S., Doi H., Imawari M
  • Journal Title: Cancer Science 99(8) Pages: 1663-1669
  • Peer Reviewed
• [Journal Article] Dendritic cells stimulated with CpG-ODN and IFN-α-expressing tumor cells effectively reduce outgrowth of established tumors in vivo (2008)
  • Author(s): Ayako Hiraide
  • Journal Title: Cancer Science 99巻・8号 Pages: 1663-1669
  • Peer Reviewed
• [Journal Article] Antigenic profiling of glioma cells to generate allogeneic vaccines or dendritic cell-based therapeutics (2007)
  • Author(s): Eguchi J. Zhang JG., Kruse CA, Gomez GG., Fakhrai H., Schroter S., Ma W, Hoa N., Minev B., Delgado C., Wepsic HT., Okada H., Jadus MR
  • Journal Title: Clinical Cancer Research 13 Pages: 566-575
  • Peer Reviewed
• [Journal Article] Toll like receptor-3 ligand poly-ICLC promotes the efficacy of peripheral vaccinations with tumor antigen-derived peptide epitopes in murine CNS tumor models (2007)
  • Author(s): Zhu X., Nishimura F., Sasaki K., Fujita M., Dusak JE.,, Zhang JG., Kruse CA, Gomez GG., Fakhrai H., Schroter S., Ma W, Hoa N., Minev B., Delgado C., Wepsic HT., Okada H
  • Journal Title: Journal of Translational Medicine 5 Pages: 10-10
  • Peer Reviewed
• [Journal Article] Antigenic profiling of glioma cells to generate allogeneic vaccines or dendritic cell-based therapeutics (2007)
  • Author(s): Eguchi, J, 他
  • Journal Title: Clinical Cancer Research 13巻・2号 Pages: 566-575
  • Peer Reviewed
• [Journal Article] TLR-3 ligand poly-ICLC promotes the efficacy of peripheral vaccinations with tumor antigen-derived peptide epitopes in murine (2007)
  • Author(s): Zhu, X, 他
  • Journal Title: Journal of Translational Medicine 5巻・10号(On line)
  • Peer Reviewed
• [Presentation] Tumor associated antigen specific CD8+ T cell responses would suppress recurrence of hepatocellular carcinoma (2009)
  • Author(s): Kazumasa Hiroishi, Hiroyoshi Doi, Toshiyuki Baba, Junichi Eguchi, Shigeaki Ishii, Ayako Hiraide, Masashi Sakaki, Manabu Uchikoshi, Yuu Shimozuma, Risa Ohmori, Takayoshi Ito, Michio, Imawari
  • Organizer: The Liver Meeting 2009, AASLD's 60st Annual Meeting
  • Place of Presentation: Boston, MA
  • Year and Date: 2009-11-03
• [Presentation] Tumor associated antigen specific CD8+ T cell responses would suppress recurrence of hepatocellular carcinoma (2009)
  • Author(s): Kazumasa Hiroishi., 他
  • Organizer: 第60回米国肝臓学会議(AASLD)
  • Place of Presentation: Boston, MA
  • Year and Date: 2009-11-03
• [Presentation] 肝細胞癌患者の腫瘍抗原特異的細胞性免疫応答と治療後肝癌再発に関する検討 (2009)
  • Author(s): 広石和正、土肥弘義、江口潤一、石井成明、広石和正、、石井成明、平出綾子、坂木理、大森里紗、伊藤敬義、馬場俊之、井廻道夫
  • Organizer: 第17回日本消化器関連学会週間(JDDW2009)
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2009-10-15
• [Presentation] マウスモデルを用いたHCV特異的T細胞エピトープの同定 (2009)
  • Author(s): 石井成明、広石和正、江口潤一、平出綾子、土肥弘義、大森里紗、井廻道夫
  • Organizer: 第17回日本消化器関連学会週間(JDDW2009)
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2009-10-15
• [Presentation] C型肝炎におけるCTLエピトープの同定とCTL応答の解析 (2009)
  • Author(s): 広石和正、江口潤一、石井成明、平出綾子、坂木理、土肥弘義、井廻道夫
  • Organizer: 第45回日本肝臓学会総会
  • Place of Presentation: 神戸ポートピアホテル
  • Year and Date: 2009-06-04
• [Presentation] インターロイキン-4とCpGを用いた消化器癌に対する免疫療法の検討 (2009)
  • Author(s): 土肥弘義、広石和正、江口潤一、石井成明、平出綾子、坂木理、井廻道夫
  • Organizer: 第95回日本消化器病学会総会
  • Place of Presentation: 北海道厚生年金会館
  • Year and Date: 2009-05-08
• [Presentation] 肝癌患者の治療前後における各種腫瘍抗原に対する細胞性免疫応答の研究 (2008)
  • Author(s): 江口潤一、広石和正、土肥弘義、平出綾子、石井成明、坂木理、馬場俊之、井廻道夫
  • Organizer: 第44回日本肝臓学会総会
  • Place of Presentation: 愛媛県県民文化会館
  • Year and Date: 2008-06-06
• [Presentation] Efficacy and mechanism of dendritic cell-based immunotherapy with CpG and IFN-alpha-expressing tumor cells for murine colorectal cancer (2008)
  • Author(s): Hiroyoshi Doi, Kazumasa Hiroishi, Ayako Hiraide, Junichi Eguchi, Shigeaki Ishii, Takuya Matsumura, Masashi Sakaki, Michio, Imawari
  • Organizer: 99th AACR Annual Meeting 2008
  • Place of Presentation: San Diego, CA
  • Year and Date: 2008-04-14
• [Presentation] IFN-α遺伝子導入細胞と樹状細胞との融合細胞による抗腫瘍免疫誘導作用の検討 (2007)
  • Author(s): 広石和正、江口潤一、井廻道夫
  • Organizer: 第15回日本消化器関連学会週間(JDDW2007)
  • Place of Presentation: 神戸ポートピアホテル
  • Year and Date: 2007-10-19
• [Presentation] IFN-α遺伝子導入細胞と樹状細胞との融合細胞による抗腫瘍免疫誘導作用の検討 (2007)
  • Author(s): 広石 和正, 他
  • Organizer: 第15回日本消化器関連学会週間(JDDW2007)
  • Place of Presentation: ポートピアホテル
  • Year and Date: 2007-10-19
• [Presentation] インターロイキン4遺伝子導入細胞を用いた免疫療法の検討 (2007)
  • Author(s): 江口潤一、広石和正、、広石和正、井廻道夫
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-10-05
• [Book] 新しい診断と治療のABC 50 消化器 7 肝癌 (2007)
  • Author(s): 江口 潤一, 他
  • Total Pages: 230
  • Publisher: 最新医学社