Role of the interaction of extracellular matrix with integrin in the cardiovascular disease

• Project/Area Number: 19790508
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Circulatory organs internal medicine
• Research Institution: Hokkaido University
• Principal Investigator: MATSUI Yutaka Hokkaido University, 遺伝子病制御研究所・マトリックスメディスン研究部門, 特任准教授 (30431381)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,780,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
• Keywords: 分子心臓病態学 / 分子血管病態学 / 細胞外マトリックス / 心血管疾患 / 組織再構築 / インテグリン

Research Abstract

動脈硬化症、心筋梗塞など難治性心血管疾患において、オステオポンチンをはじめとする細胞外マトリックスタンパクとその受容体であるインテグリンが果たす役割を、中和抗体や遺伝子改変マウスを用いて検討し、最終的には疾患の新たな治療法開発につなげることを目標とし、研究をすすめている。現在、様々な疾患モデルを作成し、中和抗体や遺伝子改変マウスを用いて、その治療効果を確認中である。以上の研究を通じて、個々の分子の役割のみならず、分子間相互作用や相乗効果、ひいては組織再構築の分子機構の全容に近づきたいと考えている。

Research Products

• [Journal Article] The differential amino acid requirement within osteopontin in alpha4 and alpha9 integrin-mediated cell binding and migration. (2009)
  • Author(s): Koyu, I., Matsui, Y., et al(11名中10番目)
  • Journal Title: Matrix boil. 28 Pages: 11-19
  • Peer Reviewed
• [Journal Article] The differential amino acid requirement within osteopontin in alpha4 and alpha9 integrin-mediated cell binding and migration (2009)
  • Author(s): Ito Koyu, et.al.
  • Journal Title: Matrix biology 28 Pages: 11-19
  • Peer Reviewed
• [Journal Article] Lats2 is a negative regulator of myocyte size in the heart. (2008)
  • Author(s): Matsui, Y., et al (11名中1番目)
  • Journal Title: Circ Res. 103 Pages: 1309-1318
  • Peer Reviewed
• [Journal Article] Molecular Mechanisms and Physiological Significance of Autophagy during Myocardial Ischemia and Reperfusion. (2008)
  • Author(s): Matsui, Y., et al (8名中1番目)
  • Journal Title: Autophagy. 4 Pages: 409-415
  • Peer Reviewed
• [Journal Article] Heparan sulfate proteoglycan, syndecan-4 regulates osteopontin mediated acute hepatic injury by masking functional domains of osteopontin. (2008)
  • Author(s): Kon, S., Matsui, Y., et al (14名中9番目)
  • Journal Title: J Exp Med. 205 Pages: 25-33
  • Peer Reviewed
• [Journal Article] Lats2 is a negative regulator of myocyte size in the heart (2008)
  • Author(s): Matsui Yutaka, et.al.
  • Journal Title: Circulation research 103 Pages: 1309-1318
  • Peer Reviewed
• [Journal Article] Syndecan-4 protects against osteopontin-mediated acute hepatic injury by masking functional domains of osteopontin (2008)
  • Author(s): Kon Shigeyuki, et.al.
  • Journal Title: The journal of experimental medicine 205 Pages: 25-33
  • Peer Reviewed
• [Journal Article] Distinct roles of autophagy in the heart during ischemia and reperfusion : roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy. (2007)
  • Author(s): Matsui, Y., et al (8名中1番目)
  • Journal Title: Circ Res. 100 Pages: 914-922
  • Peer Reviewed
• [Journal Article] Osteopontin small interfering RNA protects mice from fulminant hepatitis. (2007)
  • Author(s): Saito, Y., Matsui, Y., et al (14名中11番目)
  • Journal Title: Hum Gene Ther. 18 Pages: 1205-1214
  • Peer Reviewed
• [Presentation] Lats2 is an endogenous regulator of apoptosis and myocyte size in the heart (2008)
  • Author(s): Matsui Yutaka, et al.
  • Organizer: Scientific Sessions of American Heart Association 2008
  • Place of Presentation: New Orleans, Louisiana, USA
  • Year and Date: 2008-11-09
• [Presentation] Lats2 is an endogenous regulator of apoptosis and myocyte size in the heart (2008)
  • Author(s): Matsui Yutaka, et.al.
  • Organizer: Scientific Sessions of American Heart Association 2008
  • Place of Presentation: Ernest N Morial Conventi on Center, New Orleans, Louisiana, USA
  • Year and Date: 2008-11-09