Investigation of the mechanism in the development of atrial remodeling

• Project/Area Number: 19790515
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Circulatory organs internal medicine
• Research Institution: Yamagata University
• Principal Investigator: MIYAMOTO Takuya Yamagata University, 医学部, 助教 (20447204)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,650,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥450,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
• Keywords: 心房リモデリング / ギャップジャンクション / コネキシン / 心房筋糸胞 / connexin 43

Research Abstract

心房の構造学的変調の解明は新しい心房細動治療薬開発の糸口となりうる。頸動静脈短絡による容量負荷心肥大モデルの拡大心房筋では対照に比し、Connexin(Cx)43とβ-catenin及びGSK-3bataの蛋白発現低下が認められ、これらの蛋白間相互作用が確認された。MAP kinase(ERK1/2, JNK, p38)の蛋白発現及びリン酸化には変調を認めなかった。Cx43発現の低下は、Cx43の膜分画へ輸送や構造構築の過程の変調により起こるものと仮定し、培養心房筋細胞を用いた伸展刺激と電気刺激を同時に加えることが可能な新しい実験系にて証明を試みた。

Research Products

• [Journal Article] Persistently increased serum concentration of heart-type fatty acid-binding protein predicts adverse clinical outcomes in patients with chronic heart failure (2008)
  • Author(s): Niizeki T, Takeishi Y, Miyamoto T, Kubota I, et al.
  • Journal Title: Circulation journal 72 Pages: 109-114
  • NAID: 110006533924
  • Peer Reviewed
• [Journal Article] Risk stratification of chronic heart failure patients by multiple biomarkers: implications of BNP, H-FABP, and PTX3 (2008)
  • Author(s): Ishino M, Takeishi Y, Miyamoto T, Kubota I, et al.
  • Journal Title: Circulation journal 72(11) Pages: 1800-1805
  • NAID: 110006975572
  • Peer Reviewed
• [Journal Article] Relation of serum heart shock protein 60 level to severity and prognosis in chronic heart failure secondary to ischemic or idiopathic dilated cardiomyopathy (2008)
  • Author(s): Niizeki T, Takeishi Y, Miyamoto T, Kubota I, et al.
  • Journal Title: American Journal of Cardiology 102(5) Pages: 606-610
  • Peer Reviewed
• [Journal Article] Persistently increased serum concentration of heart-type fatty acid-binding protein predicts adverse clinical outcomes in patients with chronic heart failure (2008)
  • Author(s): Niizeki T, Takeishi Y, Miya moth T, Kubota I, et.al.
  • Journal Title: Circulation journal 72 Pages: 109-114
  • Peer Reviewed
• [Journal Article] Relation of serum heart shock protein 60 level to severity and prognosis in chronic heart failure secondary to ischemic or idiopathic dilated cardiomyopathy (2008)
  • Author(s): Niizeki T, Takeishi Y, Miyamoto T, Kubota I, et.al.
  • Journal Title: American Journal of Cardiology 102(5) Pages: 606-610
  • Peer Reviewed
• [Journal Article] Risk stratification of chronic heart failure patients by multiple biomarkers : implications of BNP, H-FABP, and PTX3 (2008)
  • Author(s): Ishino M, Takeishi Y, Miya moth T, Kubota I, et.al.
  • Journal Title: Circulation journal 72(11) Pages: 1800-1805
  • Peer Reviewed
• [Presentation] Serum midkine predicts cardiac events in chronic heart failure patients (2008)
  • Author(s): Kitahara T, Takeishi Y, Miyamoto T, Kubota I, et al.
  • Organizer: American Heart Association Scientific Sessions, 2008
  • Place of Presentation: New Orleans, USA
• [Presentation] Serum midkine predicts cardiac events in chronic heart failure patients (2008)
  • Author(s): Kitahara T, Takeishi Y, Miyamoto T, Kubota I. et.al.
  • Organizer: American Heart Association Scientific Sessions
  • Place of Presentation: New Orleans, USA
• [Book] カレントテラピー (2008)
  • Author(s): 宮本卓也、久保田功
  • Publisher: ライフメディコム