Elucidation of cell type-specific KLF5 function and identification of novel mediators of KLF5 activity.
| Project/Area Number |
19790518
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TAKEDA Norifumi The University of Tokyo, 医学部附属病院, 特任教員 (60436483)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥3,550,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | 転写因子 / 心肥大 / KLF5 / 心線維芽細胞 / 心筋リモデリング / 心線維化 / 心リモデリング |
|---|
| Research Abstract |
心筋リモデリングにおける非心筋細胞(線維芽細胞や内皮細胞)の役割が注目されている。転写因子KLF5は線維芽細胞に多く発現し、KLF5+/-マウスでは圧負荷後の心肥大・線維化が抑制された。線維芽細胞特異的にKLF5を欠損させた遺伝子改変動物を新たに樹立した所、同様に心筋リモデリングが抑制された。in vovo心筋細胞肥大に線維芽細胞が関与する初めての知見であり、線維芽細胞内KLF5が肥大促進・分泌因子を制御することが想定される。
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Report
(3 results)
Research Products
(22 results)
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[Journal Article] Kruppel-like factor 5 causes cartilage degradation through transactivation of matrix metalloproteinase 9.2008
Author(s)
Shinoda Y, Ogata N, Higashikawa A, Manabe I, Shindo T, Yamada T, Kugimiya F, Ikeda T, Kawamura N, Kawasaki Y, Tsushima K, Takeda N, Nagai R, Hoshi K, Nakamura K, Chung UI, Kawaguchi H.
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Journal Title
J Biol Chem 283
Pages: 24682-24689
Related Report
Peer Reviewed
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[Journal Article] Acyclic retinoid inhibits neointima formation through retinoic acid receptor beta-induced apoptosis.2007
Author(s)
Kada N, Suzuki T, Aizawa K, Matsumura T, Ishibashi N, Suzuki N, Takeda N, Munemasa Y, Sawaki D, Ishikawa T, Nagai R.
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Journal Title
Arterioscler Thromb Vasc Biol 27
Pages: 1535-1541
Related Report
Peer Reviewed
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