Molecular genetics of atrial fibrillation and evaluation of upstream therapy for atrial fibrillation
| Project/Area Number |
19790520
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kanazawa University |
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Principal Investigator |
HAYASHI Kenshi Kanazawa University, 附属病院, 助教 (00422642)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,880,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | 心臓病態学 / 内科 / 遺伝子 / 循環器・高血圧 / 不整脈 / 心房細動 / アップストリーム治療 |
|---|
| Research Abstract |
Atrial fibrillation (AF) has an enormous social impact because of its very high incidence, its potential for devastating clinical consequences, and the difficulty of its management . Hypertrophic cardiomyopathy (HCM) is well known risk factor for AF. However, significant proportions of patients, up to 30% in some large studies, develop AF in the absence of risk factors. We performed genetic analysis for 75 patients with lone or familial AF, and identified 3 mutations. We also clarified that the HCM patients with angiotensinogen 1 A/C polymorphism, TNNT2 mutation, or TNNI3 mutation easily develop AF compared to those without these polymorphism or mutations.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Long QT syndrome and associated gene mutation carriers in Japanese children: results from ECG screening examinations.2009
Author(s)
Hayashi K, Fujino N, Uchiyama K, Ino H, Sakata K, Konno T, Masuta E, Funada A, Sakamoto Y, Tsubokawa T, Nakashima K, Liu L, Higashida H, Hiramaru Y, Shimizu M, Yamagishi M.
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Journal Title
Clin Sci (Lond). 117(12)
Pages: 415-24
Related Report
Peer Reviewed
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[Presentation] Impact of angiotensin II Type 1 receptor A/C1166 gene polymorphism on the onset of atrial fibrillation in genotyped hypertrophic cardiomyopathy2008
Author(s)
Funada A, Ino H, Fujino N, Hayashi K, Uchiyama K, Sakata K, Masuta E, Fujita T, Sakamoto Y, Tsubokawa T, Yamagishi M.
Organizer
第72回日本循環器学会総会・学術集会
Place of Presentation
福岡国際会議場(福岡県)
Year and Date
2008-03-28
Related Report
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[Presentation] Association between atrial fibrillation and left atrial diameter in genotyped populations of hypertrophic cardiomyopathy: results from a longitudinal study2008
Author(s)
Funada A, Ino H, Fujino N, Hayashi K, Uchiyama K, Sakata K, Masuta E, Fujita T, Sakamoto Y, Tsubokawa T, Yamagishi M.
Organizer
第72回日本循環器学会総会・学術集会
Place of Presentation
福岡国際会議場(福岡県)
Year and Date
2008-03-28
Related Report
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