Examination for the contribution of the angiotensin II type1 receptor to the development of malignant arrhythmias in hypertrophied and failing hearts

• Project/Area Number: 19790525
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Circulatory organs internal medicine
• Research Institution: Kyoto University
• Principal Investigator: 中西 道郎 Kyoto University, 医学研究科, 非常勤講師 (60378726)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,780,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
• Keywords: アンジオテンシン / 不整脈 / 心肥大

Research Abstract

アンジオテンシンIIタイプ1a(AT1a)受容体欠損マウス(AT1aK0)を用いてレニン・アンジオテンシン系の頻拍性不整脈発生への関与とその分子機序を検討した。AT1a欠損は肥大心において悪性不整脈の発生を減少させ、また心不全・突然死モデルマウスの生存率を改善し、その機序としてgap junctionを形成するconnexin43蛋白発現低下抑制が考えられた。以上よりレニン・アンジオテンシン系阻害薬の抗不整脈効果とその機序が明らとなった。

Research Products

• [Journal Article] Endogenous cardiac natriuretic peptides protect the heart in a mouse model of dilated cardiomyopathy and sudden death (2009)
  • Author(s): Yasuno S, Usami S, Kuwahara K, Nakanishi M, Arai Y, Kinoshita H, Nakagawa Y, Fujiwara M, Murakami M, Ueshima K, Harada M, Nakao K.
  • Journal Title: Am J Physiol Heart Circ Physiol (in press)
• [Journal Article] Association of CT dinucleotide repeat polymorphism in the 5'-flanking region of the guanylyl cyclase (GC)-A gene with essential hypertension in the Japanese (2008)
  • Author(s): Usami S, Harada M, Kuwahara K, Nakagawa Y, Nakanishi, M, Nakao K, 他4名
  • Journal Title: Hypertens Res 31 Pages: 89-96
  • NAID: 10021261243
  • Peer Reviewed
• [Journal Article] Genetic disruption of angiotensin II type 1a receptor improves long-term survival of mice with chronic severe aortic regurgitation (2007)
  • Author(s): Nakanishi M, Harada M, Kishimoto I, Kuwahara K, Kawakami R, Nakagawa Y, Yasuno S, Usami S, Kinoshita H, Adachi Y, Fukamizu A, Saito Y, Nakao K.
  • Journal Title: Circ J. 71(8) Pages: 1310-6
  • NAID: 110006368862
• [Journal Article] Genetic disruption of angiotensin IT type 1a receptor improves long-term survival of mice with chronic severe aortic regurgitation. (2007)
  • Author(s): Nakanishi Michio
  • Journal Title: Circulation Journal 71 Pages: 1310-1316
  • Peer Reviewed
• [Journal Article] Images in cardiovascular medicine. Mitochondrial cardiomyopathy evaluated with cardiac magnetic resonance. (2007)
  • Author(s): Nakanishi Michio
  • Journal Title: Circulation 116 Pages: 25-26
  • Peer Reviewed
• [Journal Article] Association of CT dinucleotide repeat polymorphism in the 5'-flanking region of the guanylyl cyclase (GC)-A gene with essential hypertension in the Japanese (2007)
  • Author(s): Usami Satoru
  • Journal Title: Hypertension Research 31 Pages: 89-96
  • Peer Reviewed
• [Presentation] 慢性腎臓病が血中BNP濃度に及ぼす影響 (2008)
  • Author(s): 中西道郎、桑原宏一郎、中尾一和、他
  • Organizer: 第81回日本内分泌学会学術総会
  • Place of Presentation: 青森市、青森県
  • Year and Date: 2008-05-16
• [Presentation] Functional inhibition of p300 in the post-natal heart leads tomitochondrial dysfunction and cell death in mice (2008)
  • Author(s): Nakagawa Y, Kuwahara K, Akao M, Katoh M, Takemura G, Takano M, Harada M, Murakami M, Nakanisi M, Usami S,Yasuno S, Kinoshita H, Fuziwara M, Kuwabara Y, Kenj Ueshima K, Nakao K.
  • Organizer: The 72nd Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 福岡
• [Presentation] 慢性腎臓病が血中BNP濃度に及ぼす影響 (2008)
  • Author(s): 中西道郎, 原田昌樹, 桑原宏一郎, 中川靖章, 宇佐美覚, 木下秀之, 藤原正隆, 桑原佳宏, 上嶋健治, 中尾一和
  • Organizer: 第81回日本内分泌学会学術総会
  • Place of Presentation: 青森
• [Remarks]
  • URL: http://www.kuhp.kyoto-u.ac.jp/~med2/jpn/research/cardio.html