Analysis of APJ receptor in Atherosclerosis
Project/Area Number |
19790537
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Circulatory organs internal medicine
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Research Institution | Yokohama City University |
Principal Investigator |
HASHIMOTO Tatsuo Yokohama City University, 附属病院, 指導診療医 (20363806)
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Project Period (FY) |
2007 – 2008
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Project Status |
Completed (Fiscal Year 2008)
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Budget Amount *help |
¥2,770,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,600,000 (Direct Cost: ¥1,600,000)
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Keywords | 動脈硬化症 / APJ / apelin / 血管 |
Research Abstract |
機能未同定であるapelin-APJ系が、血管平滑筋において直接的な酸化ストレス作用を持ち、動脈硬化症増悪因子となりうることをマウス個体で明らかにした。本研究は新たな動脈硬化症増悪因子を同定し、それは新たな治療ターゲットの開発へとつながる可能性を示した。
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Report
(3 results)
Research Products
(29 results)
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[Journal Article] Urinary Oxidative Stress Markers Closely Reflect the Efficacy of Candesartan Treatment for Diabetic Nephropathy.2009
Author(s)
Yoshida S, Hashimoto T, Kihara M, Imai N, Yasuzaki H, Nomura K, Kiuchi Y, Tamura K, Ishigami T, Hirawa N, Toya Y, Kitamura H, Umemura S
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Requirement of apelin-apelin receptor system for oxidative stress-linked atherosclerosis.2007
Author(s)
Hashimoto T, Kihara M, Imai N, Yoshida S, Shimoyamada H, Yasuzaki H, Ishida J, Toya Y, Kiuchi Y, Hirawa N, Tamura K, Yazawa T, Kitamura H, Fukamizu A, Umemura S
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Journal Title
Am J Pathol 171
Pages: 1705-1712
Related Report
Peer Reviewed
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[Presentation] Requirement of apelin-apelin receptor system for oxidative stress-linked atherosclerosis2008
Author(s)
Hashimoto T, Kihara M, Imai N, Yoshida S, Shimoyamada H, Yasuzaki H, Ishida J, Toya Y, Kiuchi Y, Hirawa N, Tamura K, Yazawa T, Kitamura H, Fukamizu A, Umemura S
Organizer
The 22nd Scientific Meeting of the International Society of Hypertension
Place of Presentation
Berlin
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