The mechanism of cell fate determination of human EPCs and its functional therapeutic cascade

• Project/Area Number: 19790542
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Circulatory organs internal medicine
• Research Institution: Nihon University
• Principal Investigator: WADA Mika Nihon University, 医学部, 助教 (90420950)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,650,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥450,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
• Keywords: 再生医療 / Notch、Jagged-1 / 血管内皮前駆細胞(EPC) / Notch / EPC

Research Abstract

骨髄微小環境下においてNotchリガンドであるJagged-1はヒト未分化前駆細胞の維持および血管系への増殖・分化を促し、Dll-1は抑制することが示された。本研究で開発されたJagged-1発現骨髄ストローマ細胞を用いて、ヒト血管新生に効率的な細胞を体外増幅することが可能となり、細胞再生医療の新たな発展につながった。

Research Products

• [Journal Article] Specific Jagged-1 signal from bone marrow microenvironment is required for endothelial progenitor cell development for neovascularization (2008)
  • Author(s): Kwon SM, Eguchi M, Wada M, Iwami Y, Hozumi K, Iwaguro H, Masuda H, Kawamoto A, Asahara T
  • Journal Title: Circulation 118(2)
  • Peer Reviewed
• [Journal Article] The Effects of Flap Ischemia on Normal and Diabetic Progenitor Cell Function (2008)
  • Author(s): Rica Tanaka, Mika Wada, Sang Mo Kwon, Haruchika Masuda, Rie Ito, Jacquelyn Carr, Muneo Miyasaka, Stephen M Warren, Takayuki Asahara, Oren Tepper
  • Journal Title: Plastic and Reconstructive Surgery 121(6) Pages: 1929-42
  • Peer Reviewed
• [Journal Article] Specific Jagged-1 signal from bone marrow microenvironment is require d for endothelial progenitor cell development for neovascularization (2008)
  • Author(s): Kwon SM
  • Journal Title: Circulation 118 Pages: 157-165
  • Peer Reviewed
• [Journal Article] The Effects of Flap Ischemia on Normal and Diabetic Progenitor Cell Function (2008)
  • Author(s): Rica Tanaka
  • Journal Title: Plastic and Reconstructive Surgery 121 Pages: 1929-1942
  • Peer Reviewed
• [Presentation] ヒトCD133陽性細胞由来血管内皮前駆細胞におけるNotchシグナルの役割 (2009)
  • Author(s): 和田美夏、權相模、江口正倫、伊藤理恵、小堀みちる、穂積勝人、松本太郎、麦島秀雄、増田治史、浅原孝之
  • Organizer: 第11回循環器再生医療研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-05-23
• [Presentation] ヒトCD133陽性細胞由来血管内皮前駆細胞におけるNotchシグナルの役割 (2009)
  • Author(s): 和田美夏、權相模、江口正倫、伊藤理恵、小堀みちる、穂積勝人、松本太郎、麦島秀雄、増田治史、浅原孝之
  • Organizer: 第8回日本再生医療学会
  • Place of Presentation: 東京
  • Year and Date: 2009-03-05
• [Presentation] ヒトCD133陽性細胞由来血管内皮前駆細胞におけるNotchシグナルの役割 (2009)
  • Author(s): 和田美夏
  • Organizer: 日本再生医療学会
  • Place of Presentation: 東京
  • Year and Date: 2009-03-05