The Impact of Atorvastatin on Stabilization of Coronary Vulnerable Plaque

• Project/Area Number: 19790545
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Circulatory organs internal medicine
• Research Institution: Hyogo College of Medicine
• Principal Investigator: FUJII Kenichi Hyogo College of Medicine, 医学部, 助教 (90434943)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,390,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
• Keywords: 血管病態学 / 冠動脈不安定粥腫 / 急性心筋梗塞 / HMG-CoA阻害剤 / 冠動脈不安定プラーク / 動脈硬化

Research Abstract

光干渉断層画像を用いて不安定冠動脈粥腫の主体である、脂質コアと薄い繊維性被膜を定量的に測定し、アトルバスタチンを無作為に高用量と低用量に振り分け1年間投与がそれらに与える影響について調査したところ、冠動脈プラークの体積、OCTで計測された繊維性被膜厚、Lipidpool最大角度の変化には両群間で有意な差を認めることができなかった。しかし、本研究で冠動脈不安定粥腫を生体内で検出可能であることが証明され、それら冠動脈不安定粥腫は冠動脈の特定の部位に分布していることがわかった。

Research Products

• [Journal Article] Effect of culprit-lesion remodeling versus plaque rupture on three-year outcome in patients with acute coronary syndrome (2009)
  • Author(s): Okura H, Kobayashi Y, Sumitsuji S, Terashima M, Kataoka T, Masutani M, Ohyanagi M, Shimada K, Taguchi H, Yasuga Y, Takeda Y, Ohashi Y, Awano K, Fujii K, Mintz GS.
  • Journal Title: Am J Cardiol 103(6) Pages: 791-795
  • Peer Reviewed
• [Journal Article] Frequency and Predictor of Coronary Thin-cap Fibroatheroma in Patients With Acute Myocardial Infarction and Stable Angina Pectoris: A Three-Vessel Optical Coherence Tomography Study (2008)
  • Author(s): Fujii K, Masutani M, Okumura T, Kawasaki D, Akagami T, Ezumi A, Sakoda T, Masuyama T, Ohyanagi M
  • Journal Title: J Am Coll Cardiol 52(9) Pages: 787-788
  • Peer Reviewed
• [Journal Article] Contribution of organized thrombus to in-stent restenosis after sirolimus-eluting stent implantation : optical coherence tomography findings (2008)
  • Author(s): Fujii K, Masutani M, Ohyanagi M.
  • Journal Title: Eur Heart J 29(11) Pages: 1385-1385
  • Peer Reviewed
• [Journal Article] Novel use of ultrasound guidance for recanalization of iliac, femoral, and popliteal arteries (2008)
  • Author(s): Kawasaki D, Tsujino T, Fujii K, Masutani M, Ohyanagi M, Masuyama T.
  • Journal Title: Catheter Cardiovasc Interv 71(6) Pages: 727-33
  • Peer Reviewed
• [Journal Article] Frequency and Predictor of Coronary Thin-cap Fibroatheroma in Patients With Acute Myocardial Infarction and Stable Angina Pectoris : A Three-Vessel Optical Coherence Tomography Study (2008)
  • Author(s): Kenichi Fujii
  • Journal Title: Journal of American College of Cardiology 52(9) Pages: 787-788
  • Peer Reviewed
• [Journal Article] The accuracy of length measurements using different intravascular ultrasound motorized transducer pullback systems (2007)
  • Author(s): Tanaka K, Carlier SG, Mintz GS, Sano K, Liu X, Fujii K, de Ribamar Costa J Jr, Lui J, Moses JW, Stone GW, Leon MB
  • Journal Title: Int J Cardiovasc Imaging 23(6) Pages: 733-738
  • Peer Reviewed
• [Journal Article] Intravascular ultrasound assessment of drug-eluting stent expansion (2007)
  • Author(s): de Ribamar Costa J Jr, Mintz GS, Carlier SG, Fujii K, Sano K, Kimura M, Tanaka K, Costa RA, Lui J, Na Y, Castellanos C, Biro S, Moussa I, Stone GW, Moses JW, Leon MB.
  • Journal Title: Am Heart J. 153(2) Pages: 297-303
  • Peer Reviewed
• [Presentation] Effect of pravastatin pretreatment to elective percutaneous coronar intervention on periprocedural microcirculatory injury (2009)
  • Author(s): Kenichi Fujii
  • Organizer: 第73回日本循環器学会総会・学術集会
  • Place of Presentation: 大阪
• [Presentation] Multiple complex coronary atherosclerosis in diabetic patients with acute myocardial infarction : a three-vessel optical coherence tomography study (2008)
  • Author(s): Fujii K, Masutani M, Okumura T, Kawasaki D, Akagami T, Ezumi A, Sakoda T, Masuyama T, Ohyanagi M.
  • Organizer: 第17回日本心血管インターベンション学会学術集会
  • Place of Presentation: 名古屋
• [Presentation] Predictive factors for the no-reflow and slow-flow phenomenon in patients with reperfused acute myocardial infarction (2008)
  • Author(s): Fujii K, Masutani M, Ezumi A, Sakoda T, Masuyama T, Ohyanagi M.
  • Organizer: 第72回日本循環器学会総会・学術集会
  • Place of Presentation: 福岡
• [Presentation] Clinical pathways in acute myocardial infarction for early discharge and cost benefit (2008)
  • Author(s): Mori Y, Masutani M, Doi T, Oka K, Fujii K, Naka T, Kawasaki D, Okumura T, Yuba M, Masuyama T, Ohyanagi M
  • Organizer: 第72回日本循環器学会総会・学術集会
  • Place of Presentation: 福岡
• [Presentation] Culprit lesion remodeling affects long-term clinical outcome in patients with acute coronary syndrome : A prospective, multicenter, three-vessel intravascular ultrasound study (2008)
  • Author(s): Taguchi H, Okura H, Kobayashi Y, Sumitsuji S, Terashima M, Kataoka T, Masutani M, Ohyanagi M, Shimada K, Yasuga Y, Takeda Y, Ohashi Y, Awano K, Fujii K, Mintz GS.
  • Organizer: 第72回日本循環器学会総会・学術集会
  • Place of Presentation: 福岡
• [Presentation] Non-culprit coronary plaque morphology in patients with acute myocardial infarction : An optical coherence tomography study in vivo (2008)
  • Author(s): Fujii K, Masutani M, Okumura T, Kawasaki D, Akagami T, Ezumi A, Sakoda T, Masuyama T, Ohyanagi M.
  • Organizer: 第72回日本循環器学会総会・学術集会
  • Place of Presentation: 福岡
• [Presentation] Ohyanagi M. Comparison of thin-cap fibroatheroma between acute myocardial infarction and stable angina pectoris : A three-vessel optical coherence tomography study (2008)
  • Author(s): Fujii K, Masutani M, Okumura T, Kawasaki D, Akagami T, Ezumi A, Sakoda T, Masuyama T
  • Organizer: 第72回日本循環器学会総会・学術集会
  • Place of Presentation: 福岡
• [Presentation] Thin-cap fibroatheroma : Insights from optical coherence tomography (2008)
  • Author(s): Fujii K, Masuyama T, Ohyanagi M.
  • Organizer: 第72回日本循環器学会総会・学術集会
  • Place of Presentation: 福岡
• [Presentation] The spatial and transversal distribution of thin-cap fibroatheroma in the left anterior descending coronary artery : an optical coherence tomography study (2008)
  • Author(s): Kenichi Fujii
  • Organizer: 第73回日本循環器学会総会・学術集会
  • Place of Presentation: 大阪
• [Presentation] Morphologic Feature and Frequency of Coronary Pre-Rupture Thin-cap Fibroatheroma in Patients With Acute Myocardial Infarctionand Stable Angina Pectoris: A Three-Vessel Optical Coherence Tomography Study (2007)
  • Author(s): Kenichi Fujii
  • Organizer: American Heart Association
  • Place of Presentation: 米国
  • Year and Date: 2007-11-07
• [Presentation] Morphologic Feature and Frequency of Coronary Pre-Rupture Thin-cap Fibroatheroma in Patients With Acute Myocardial Infarction and Stable Angina Pectoris: A Three-Vessel Optical Coherence Tomography Study (2007)
  • Author(s): Kenichi Fujii
  • Organizer: European Society of Cardiology
  • Place of Presentation: オーストリア
  • Year and Date: 2007-09-02
• [Presentation] Optical Coherence Tomographyによる冠動脈不安定粥腫の検討 (2007)
  • Author(s): 藤井健一,舛谷元丸,奥村隆啓,川崎大三,赤神隆文,森本真史,増山理,大柳光正
  • Organizer: 第55回日本心臓病学会学術集会
  • Place of Presentation: 千葉
• [Presentation] CTO by IKATEN (2007)
  • Author(s): 舛谷元丸,森本真史,弓場雅夫,奥村隆啓,川崎大三,森可智,中聡夫,藤井健一,土居隆,岡克己,赤神隆文,増山理,大柳光正
  • Organizer: 第16回日本心血管インターベンション学会学術集会
  • Place of Presentation: 福島
• [Presentation] Coronary artery spatial distribution of thin-cap fibroatheroma : a three-vessel optical coherence tomography study (2007)
  • Author(s): 藤井健一,舛谷元丸,奥村隆啓,川崎大三,赤神隆文,森本真史,増山理,大柳光正
  • Organizer: 第16回日本心血管インターベンション学会学術集会
  • Place of Presentation: 福島
• [Presentation] Incidence and morphologic features of ruptured plaques in lower limbs in patients with peripheral artery disease : An intravascular ultrasound study (2007)
  • Author(s): 川崎大三,舛谷元丸,藤井健一,大柳光正,増山理
  • Organizer: 第16回日本心血管インターベンション学会学術集会
  • Place of Presentation: 福島
• [Presentation] DESの基本構造と成績 (2007)
  • Author(s): 藤井健一
  • Organizer: 第16回日本心血管インターベンション学会学術集会
  • Place of Presentation: 福島
• [Presentation] 急性心筋梗塞患者と安定狭心症患者における冠動脈不安定粥腫の比較検討 (2007)
  • Author(s): 藤井健一,舛谷元丸,辻野健,増山理,大柳光正
  • Organizer: 第104回日本内科学会講演会
  • Place of Presentation: 大阪