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Development of the new cardiovascular disease therapy making the most of unique characterization of physiologically active peptides.

Research Project

Project/Area Number 19790548
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

TOKUDOME Takeshi  National Cardiovascular Center Research Institute, 高血圧研究室, 室長 (00443474)

Co-Investigator(Kenkyū-buntansha) 堀尾 武史  国立循環器病センター研究所, 内科・高血圧腎臓部門, 医員 (50393228)
岸本 一郎  国立循環器病センター研究所, 内科・動脈硬化代謝部門, 医員 (80312221)
寒川 賢治  国立循環器病センター研究所, 研究所, 所長 (00112417)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,690,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,000,000 (Direct Cost: ¥2,000,000)
Keywords心臓病態学 / ANP / BNP / GC-A / 心肥大 / RGS4 / カルシニューリン / グレリン / 心筋梗塞 / 心臓交感神経 / 致死性不整脈
Research Abstract

心筋梗塞モデル動物を用いた検討により、胃から分泌される摂食亢進ホルモンであるグレリンの投与が、心筋梗塞急性期の致死性不整脈の発生を、交感神経活動抑制により顕著に減少させ、死亡率を有意に減少させることに成功した。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (16 results)

All 2008 2007 Other

All Journal Article (12 results) (of which Peer Reviewed: 5 results) Presentation (3 results) Remarks (1 results)

  • [Journal Article] Exogenous ghrelin attenuates the progression of chronic hypoxia-induced pulmonary hypertension in conscious rats.2008

    • Author(s)
      Schwenke DO, Tokudome T, Shirai M, Hosoda H, Horio T, Kishimoto I, Kangawa K
    • Journal Title

      Endocrinology 149(1)

      Pages: 237-44

    • Related Report
      2008 Final Research Report
  • [Journal Article] Ghrelin Suppresses Cardiac Sympathetic Activity and Prevents Early Left Ventricular Remodeling in Rats With Myocardial Infarction.2008

    • Author(s)
      Soeki T, Kishimoto I, Schwenke DO, Tokudome T, Horio T, Yoshida M, Hosoda H, Kangawa K
    • Journal Title

      Am J Physiol Heart Circ Physiol 294(1)

    • Related Report
      2008 Final Research Report
  • [Journal Article] RGS4 mediates anti-hypertrophic effect of locally secreted natriuretic peptides in the heart.2008

    • Author(s)
      Tokudome T, Kishimoto I, Horio T, Arai Y, Schwenke DO, Hino J, Okano I, Kawano Y, Kohno M, Miyazato M, Nakao K,Kangawa K
    • Journal Title

      Circulation 117

      Pages: 2329-2339

    • Related Report
      2008 Final Research Report
  • [Journal Article] Early ghrelin treatment following myocardial infarction prevents an increase in cardiac sympathetic tone and reduces mortality.2008

    • Author(s)
      Schwenke DO, Tokudome T, Shirai M, Horio T, Kishimoto I, Klagg P, Kangawa K
    • Journal Title

      Endocrinology 149

      Pages: 5127-5176

    • Related Report
      2008 Final Research Report
  • [Journal Article] RGS4 mediates anti-hypertrophic effect of locally secreted natriuretic peptides in the heart.2008

    • Author(s)
      Takeshi Tokudome, et al.
    • Journal Title

      Circulation 117

      Pages: 2329-2339

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Early ghrelin treatment following myocardial infarction prevents an increase in cardiacsympathetic tone and reduces mortality2008

    • Author(s)
      Schwenke DO, et al.
    • Journal Title

      Endocrinology 149

      Pages: 5172-5176

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cardioprotective effects of natriuretic peptides2008

    • Author(s)
      Ichiro Kishimoto, et al.
    • Journal Title

      J Neuroendocrinolgy 20

      Pages: 1213-1223

    • NAID

      40015438296

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ghrelin suppresses cardiac sympathetic activity and prevents early left ventricular remodeling in rats with myocardial infarction2008

    • Author(s)
      Takeshi Soeki, et. al.
    • Journal Title

      Am J Physiol Heart Circ Physiol 294

      Pages: 426-432

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exogenous ghrelin attenuates the progression of chronic hypoxia-induced pulmonary hypertension in conscious rats.2008

    • Author(s)
      Schwenke DO., et. al.
    • Journal Title

      Endocrinology 149

      Pages: 237-244

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cardioprotective effects of natriuretic peptides.2007

    • Author(s)
      Tokudome T, Kishimoto I, Horio T, kangawa K.
    • Journal Title

      Nippon Rinsho 65(Suppl 4)

      Pages: 165-169

    • NAID

      40015438296

    • Related Report
      2008 Final Research Report
  • [Journal Article] Cardioprotective effects of natriuretic peptides2007

    • Author(s)
      Takeshi Tokudome, et. al.
    • Journal Title

      Nippon Rinsho 65 Suppl 4

      Pages: 165-169

    • NAID

      40015438296

    • Related Report
      2007 Annual Research Report
  • [Journal Article] C-type natriuretic peptide is a Schwann cell-derived factor for development and function of sensory neurons.

    • Author(s)
      Kishimoto I, Tokudome T, Horio T, Soeki T, Chusho H, Nakao K, Kangawa K
    • Journal Title

      J Neuroendocrinol 20(11)

      Pages: 1213-1223

    • Related Report
      2008 Final Research Report
  • [Presentation] Regulator of G-protein Signaling 4 Mediates Antihypertrophic Effect of Endogenous Natriuretic Peptides in the Heart.2008

    • Author(s)
      徳留 健
    • Organizer
      第31回日本高血圧学会
    • Place of Presentation
      ロイトン札幌
    • Year and Date
      2008-10-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] Regulator of G-protein Signaling 4 Mediates Antihypertrophic Effect of Endogenous Natriuretic Peptides in the Heart2007

    • Author(s)
      徳留 健
    • Organizer
      第11回日本心不全学会(YIA口演)
    • Place of Presentation
      浦安(ヒルトン東京ベイ)
    • Year and Date
      2007-09-09
    • Related Report
      2007 Annual Research Report
  • [Presentation] Regulator of G-protein Signaling 4 Mediates Antihypertropnic Effect of Endogenous Natriuretic Peptides in the heart.

    • Author(s)
      徳留 健
    • Organizer
      第11回日本心不全学会(YIA口演)
    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://www.ncvc.go.jp/res/byoin/byoinj_04.html^#c

    • Related Report
      2008 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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