Regulation of adipokine by SLPI

• Project/Area Number: 19790551
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Respiratory organ internal medicine
• Research Institution: Tohoku University
• Principal Investigator: FUKUHARA Tatsuro Tohoku University, 病院, 助教 (80400365)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,620,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥420,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2007: ¥1,800,000 (Direct Cost: ¥1,800,000)
• Keywords: SLPI / アディポカイン / 発癌 / cell senescellce

Research Abstract

蛋白分解酵素阻害物質SLPIは、アディポカインを抑制していることが明らかとなったが、マウスの実験系において、脂質糖代謝系への影響は明らかではなく、その生理的意義は不明であった。一方、肺の上皮細胞株においては、SLPIは増殖能を高めているが、浸潤・遊走能への影響は明らかではなく、蛋自分解酵素阻害作用以外の肺上皮細胞への作用の存在が示唆された。

Research Products

• [Journal Article] Suppression of surfactant protein A by an epidermal growth factor receptor tyrosine kinase inhibitor exacerbates lung innammation. (2008)
  • Author(s): Inoue A, Xin H, Suzuki T, Kanehira M, Kuroki Y, Fukuhara T, 他4名
  • Journal Title: Cancer Sci. Aug Pages: 1679-1684
  • Peer Reviewed
• [Journal Article] Secretory leukocyte peptidase inhibitor and lung cancer. (2008)
  • Author(s): Nukiwa T, Suzuki T, Fukuhara T, Kikuchi T
  • Journal Title: Cancer Sci. May Pages: 849-855
  • NAID: 10024005504
  • Peer Reviewed
• [Journal Article] Suppression of surfactant protein A by an epidermal growth factor rece ptor tyrosine kinase inhibitor exacerbates lung inflammation (2008)
  • Author(s): Inoue A, Xin H T, et.al.
  • Journal Title: Cancer sci. 99 Pages: 1679-1684
  • Peer Reviewed
• [Journal Article] Secretory leukocyte peptidase inhibitor and lung cancer. (2008)
  • Author(s): Nukiwa T, Suzuki T, et. al.
  • Journal Title: Cancer sci. 99 Pages: 849-855
  • Peer Reviewed
• [Presentation] 蛋白分解酵素阻害物質Secretory leukoprotease inhibitor (SLPI)の肺癌形成における役割 (2008)
  • Author(s): 福原達朗、鈴木拓児他
  • Organizer: 日本癌学会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-28
• [Presentation] 蛋白分解酵素阻害物質Secretory leukoprotease inhibitor(SLPI)の肺癌形成における役割 (2008)
  • Author(s): 福原達朗, 鈴木拓児, 他
  • Organizer: 日本癌学会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2008-10-28
• [Presentation] 蛋白分解酵素阻害物質Secretory leukoprotease inhibitor (SLPI)による肺癌形成促進の機序 (2007)
  • Author(s): 福原達朗、鈴木拓児他
  • Organizer: 日本癌学
  • Place of Presentation: 千葉
  • Year and Date: 2007-10-04
• [Presentation] 蛋白分解酵素阻害物質Secretory leukoprotease inhibitor (SLPI)による肺癌形成促進の機序 (2007)
  • Author(s): 福原 達朗, 鈴木 拓児, 他
  • Organizer: 日本癌学会
  • Place of Presentation: 横浜 幕張メッセ
  • Year and Date: 2007-10-04