Molecular analysls of transcriptional function of SLPI

• Project/Area Number: 19790554
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Respiratory organ internal medicine
• Research Institution: Tohoku University
• Principal Investigator: SAKAKIBARA Tomohiro Tohoku University, 病院, 助教 (80422111)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,030,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2007: ¥1,600,000 (Direct Cost: ¥1,600,000)
• Keywords: SLPI / 結合タンパク質 / 結合蛋白質 / 抗体

Research Abstract

肺組織に存在するタンパク分解酵素阻害であるSLPIは様々な肺疾患に関与する可能性がある。その機能を解明するために、SLPI結合タンパク質の候補であるTaxREB107に関して、SLPIとの結合を確認し、さらに新規SLPI結合タンパク質を検索した。しかし実験結果において、SLPIとTaxREB107との結合は証明されず、また新規SLPI結合タンパク質も同定できなかった。

Research Products

• [Journal Article] Successful treatment of carcinomatous meningitis with gefitinib in a patient with lung adenocarcinoma harboring a mutated EGF receptor gene (2008)
  • Author(s): 福原達朗、榊原智博、ほか6名
  • Journal Title: Tohoku J Exp Med 4月号 Pages: 359-363
  • NAID: 10024167697
  • Peer Reviewed
• [Journal Article] Adenocarcinoma With Epidermal Growth Factor Receptor Gene Mutations in Three Siblings (2008)
  • Author(s): 榊原智博、ほか7名
  • Journal Title: Journal of Thoracic Oncology 3月号 Pages: 311-313
  • Peer Reviewed
• [Journal Article] Successful treatment of carcinomatous meningitis with gefitinib in a pat ient with lung adenocarcinoma harboring a mutated EGF receptor gene (2008)
  • Author(s): 福原達朗、榊原智博, 他6名
  • Journal Title: Tohoku J Exp Med 214 Pages: 359-363
  • NAID: 10024167697
  • Peer Reviewed
• [Journal Article] Adenocarcinoma With Epidermal Growth Factor Receptor Gene Mutations in Three Siblings (2008)
  • Author(s): 榊原智博, 他7名
  • Journal Title: Journal of Thoracic Oncology 3 Pages: 311-313
  • Peer Reviewed