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Function Analysis of immune globulin in the pathogenesis of bronchial asthma

Research Project

Project/Area Number 19790557
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Respiratory organ internal medicine
Research InstitutionKobe University

Principal Investigator

KOBAYASHI Kazuyuki  Kobe University, 医学部・附属病院, 特定助教 (50403275)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,570,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥2,400,000 (Direct Cost: ¥2,400,000)
Keywords気管支喘息 / 大量免疫グロブリン療法 / 抗原提示細胞 / 免疫グロブリン / 樹状細胞
Research Abstract

気道粘膜におけるIgG輸送がFcRnを介して行われていることを示した。また、喘息モデルマウスに外因性にIgGを投与したところ喘息が軽減することが示された。この効果は特にIgG1型の免疫グロブリンで顕著であったが、FcγレセプターIIBを欠損させたマウスでは効果は認められなかった。これは肺の抗原提示細胞の活性化修飾によるもので、FcγレセプターIIB欠損マウスに野生型マウスの骨髄から誘導した抗原提示細胞を移植することで、野生型マウス同様にIgGの抑制効果を認めたことで証明された。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (6 results)

All 2008 2007

All Presentation (6 results)

  • [Presentation] IgG Ameliorates Inflammation via Fcγ Receptor IIB pn Lung CD11c+ Cells2008

    • Author(s)
      Masatsugu Yamamoto, Kazuyuki Kobayashi
    • Organizer
      ERS 2008
    • Place of Presentation
      Berlin, Germany
    • Year and Date
      2008-10-07
    • Related Report
      2008 Final Research Report
  • [Presentation] Intratracheal instillation of antigen specific IgG ameliorated murine bronchial asthma via reduction of antigen2008

    • Author(s)
      Yumiko Ishikawa, Kazuyuki Kobayashi
    • Organizer
      ERS 2008
    • Place of Presentation
      Berlin, Germany
    • Year and Date
      2008-10-06
    • Related Report
      2008 Final Research Report
  • [Presentation] Intravenous IgG Ameliorates Allergic Airway inflammation via Fcgamma Receptor IIB2008

    • Author(s)
      Yumiko Ishikawa, Kazuuki Kobayashi
    • Organizer
      ATS 2008 International Conference
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2008-05-17
    • Related Report
      2008 Final Research Report
  • [Presentation] Intravenous IgG Ameliorates Allergic Airway Inflammation via Fcgamma Receptor IIB2008

    • Author(s)
      Y Ishikawa, K Kobayashi, et.al.
    • Organizer
      ATS 2008 International Conference
    • Place of Presentation
      トロント(カナダ)
    • Related Report
      2008 Annual Research Report
  • [Presentation] Intratracheal instillation of antigen specific IgG ameliorated murine bronchial asthma via reduction of antigen presentation of airway dendritic cells2008

    • Author(s)
      Y Ishikawa, K Kobayashi, et.al.
    • Organizer
      ERS 2008
    • Place of Presentation
      ベルリン(ドイツ)
    • Related Report
      2008 Annual Research Report
  • [Presentation] IgG静注はFcg受容体IIBを介してアレルギー性気道炎症を抑制する2007

    • Author(s)
      山本正嗣, 小林和幸
    • Organizer
      第57回日本アレルギー学会秋季学術大会
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Year and Date
      2007-11-01
    • Related Report
      2008 Final Research Report 2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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