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Search on genes related to depressive symptoms in COPD

Research Project

Project/Area Number 19790570
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Respiratory organ internal medicine
Research InstitutionNippon Medical School

Principal Investigator

ISHII Takeo  Nippon Medical School, 医学部, 助教 (90445750)

Project Period (FY) 2007 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥3,920,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥720,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥800,000 (Direct Cost: ¥800,000)
Keywords慢性閉塞性肺疾患 / 欝症状 / セロトニン代謝関連遺伝子 / 肺高血圧 / 睡眠時無呼吸症候群 / 肥満 / 鬱症状
Research Abstract

A serotonin transporter gene, SLC6A4, is thought to be related to nicotine dependence and depression, one of the comorbidities of chronic obstructive pulmonary disease (COPD). The rare allele rs2020936 was significantly associated with COPD incidence in the trend model (P=0.003 ; odds ratio, 2.20 ; 95% confidence interval, 1.31-3.74). This allele was also associated with the number of pack-years (P=0.026). The major allele of another SNP of SLC6A4, namely rs3794808, correlated with the HADS depression score (P=0.016). We conclude that SLC6A4 variation affects COPD pathogenesis, and this effect depends partly on tobacco consumption. SLC6A4 variation also affects depressive symptoms. SLC6A4 could be modified to prevent COPD and treat the depressive symptoms of COPD.

Report

(6 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report   Self-evaluation Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (14 results)

All 2010 2009 2008

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (12 results)

  • [Journal Article] Association of serotonin transporter gene variation with smoking, chronic obstructive pulmonary disease, and its depressive symptoms.2010

    • Author(s)
      Ishii T, et al.
    • Journal Title

      Journal of Human Genetics. 56

      Pages: 41-46

    • NAID

      10030657316

    • Related Report
      2010 Final Research Report
  • [Journal Article] Association of serotonin transporter gene variation with smoking, chronic obstructive pulmonary disease, and its depressive symptoms.2010

    • Author(s)
      Ishii T, et al.
    • Journal Title

      Journal of Human Genetics

      Volume: 56 Pages: 41-46

    • NAID

      10030657316

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Association of serotonin transporter gene variation with smoking, COPD and its depressive symptoms.2010

    • Author(s)
      Takeo ISHII, et al.
    • Organizer
      ATS[American Thoracic Society]2010
    • Place of Presentation
      ニューオリンズ(アメリカ)
    • Year and Date
      2010-05-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Serotonin transporter 遺伝子とうつ合併の気道病変型COPDとの関連2010

    • Author(s)
      石井健男, 他
    • Organizer
      第50回日本呼吸器学会総会
    • Place of Presentation
      京都
    • Year and Date
      2010-04-25
    • Related Report
      2010 Final Research Report
  • [Presentation] Serotonin transporter遺伝子とうつ合併の気道病変型COPDとの関連2010

    • Author(s)
      石井健男, 他
    • Organizer
      第50回日本呼吸器学会学術講演会
    • Place of Presentation
      京都(日本)
    • Year and Date
      2010-04-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] COPDのgeneticsとphenotypes.2010

    • Author(s)
      石井健男, 他
    • Organizer
      第2回呼吸機能イメージング研究会
    • Place of Presentation
      沖縄
    • Year and Date
      2010-01-30
    • Related Report
      2010 Final Research Report 2009 Self-evaluation Report
  • [Presentation] COPDのgeneticsとphenotypes2010

    • Author(s)
      石井健男, 他
    • Organizer
      第2回呼吸機能イメージング研究会
    • Place of Presentation
      沖縄
    • Year and Date
      2010-01-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Association of serotonin transporter gene variation with smoking, COPD, and its depressive symptoms.2010

    • Author(s)
      石井健男, 他
    • Organizer
      ATS [American Thoracic Society] 2009.
    • Place of Presentation
      ニューオリンズ(アメリカ)
    • Related Report
      2010 Final Research Report
  • [Presentation] 慢性閉塞性肺疾患における鬱症状規定因子の検討及びQOLとの関係2009

    • Author(s)
      石井健男, 他
    • Organizer
      第49回日本呼吸器学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-06-13
    • Related Report
      2010 Final Research Report 2009 Annual Research Report 2009 Self-evaluation Report
  • [Presentation] 慢性閉塞性肺疾患における欝症状規定因子の検討2008

    • Author(s)
      石井健男, 他
    • Organizer
      日本呼吸器学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2008-06-17
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] 慢性閉塞性肺疾患における鬱症状規定因子の検討2008

    • Author(s)
      石井健男, 他
    • Organizer
      日本呼吸器学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2008-06-17
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] The factors related to depressive symptoms in chronic obstructive pulmonary disease.2008

    • Author(s)
      石井健男, 他
    • Organizer
      ATS [American Thoracic Society] 2008.
    • Place of Presentation
      トロント(カナダ)
    • Year and Date
      2008-05-18
    • Related Report
      2010 Final Research Report
  • [Presentation] The factors reLated to depressive symptoms in chronic obs tructive pulmonary disease.2008

    • Author(s)
      石井健男, 他
    • Organizer
      ATS [Am erican Thoracic Society] 2008
    • Place of Presentation
      トロント(カナダ)
    • Year and Date
      2008-05-18
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] The factors related to depressive symptoms in chronic obstruct lye oulmonary disease2008

    • Author(s)
      石井健男、他
    • Organizer
      ATS [American Thoracic Society]2008
    • Place of Presentation
      トロント(カナダ)
    • Year and Date
      2008-05-18
    • Related Report
      2008 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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