The role of Dendritic cells for the autoimmune kidney injury

• Project/Area Number: 19790578
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Kidney internal medicine
• Research Institution: Kanazawa University
• Principal Investigator: IWATA Yasunori Kanazawa University, 保健管理センター, 助教 (90432137)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,090,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥1,400,000 (Direct Cost: ¥1,400,000)
• Keywords: 自己免疫性疾患 / 樹状細胞 / ループス腎炎 / HMGB-1 / 内科 / 免疫学 / 細胞・組織

Research Abstract

ヒト全身性エリテマトーシス類似の病態を呈するMRL-Fas^<lpr>マウスを用いて自己免疫性腎障害における樹状細胞(DCs)とp38MAPKの関与を検討した. われわれの結果よりDCsはp38MAPK活性化を介して自己免疫性臓器障害の進展に関与することが示唆された. 樹状細胞の制御は自己免疫性臓器障害の新たな治療標的として有用であると考えられた。

Research Products

• [Journal Article] Dendritic cells contribute to autoimmune kidney injury in MRL-Faslpr mice. Dendritic cells contribute to autoimmune kidney injury in MRL-Fas^<lpr> mice. (2009)
  • Author(s): Iwata Y, Furuichi K, Sakai N, Yamauchi H, Shinozaki Y, Shu K, Kurokawa Y, Toyama T, Kitajima S, Okumura T, Yamada S, Maruyama I, Matsushima K, Kaneko S, Wada T
  • Journal Title: Journal of Rheumatology. 36 Pages: 306-314
• [Journal Article] Dendritic cells contribute to autoimmune kidney injury in MRL-Fas^<1pr> mice (2009)
  • Author(s): Iwata Y., et.al.
  • Journal Title: Journal of Rheumatology 36 Pages: 306-314
  • Peer Reviewed
• [Journal Article] Combined pure red cell aplasia and autoimmune hemolytic anemia in systemic lupus erythematosus with anti-erythropoietin autoantibodies. (2008)
  • Author(s): Hara A, Wada T, Kitajima S, Toyama T, Okumura T, Kitagawa K, Iwata Y, Sakai N, Furuichi K, Higuchi M, Kaneko S
  • Journal Title: American Journal of hematology 83 Pages: 750-752
  • NAID: 120001130482
• [Journal Article] Thyroid crisis following interstitial nephritis (2008)
  • Author(s): Kahara T, Yoshizawa M, Nakaya I, Uchiyama A, Miwa A, Iwata Y, Torita M, Usuda R, Iida H
  • Journal Title: Internal Medicine 47 Pages: 1237-1240
  • NAID: 130000078836
• [Journal Article] Combined pure red cell aplasia and autoimmune hemolytic anemia in systemic lupus erythematosus with anti-erythropoietin autoantibodies (2008)
  • Author(s): Hara A., et.al.
  • Journal Title: American Journal of hematology 83 Pages: 750-752
  • Peer Reviewed
• [Journal Article] Thyroid crisis following interstitial nephritis (2008)
  • Author(s): Kahara T, et.al.
  • Journal Title: Internal Medicine 47 Pages: 1237-1240
  • Peer Reviewed
• [Presentation] 自己免疫性腎障害における樹状細胞の関与 (2008)
  • Author(s): 岩田恭宜, 他
  • Organizer: 第52回日本リウマチ学会総会
  • Place of Presentation: ロイトン札幌
  • Year and Date: 2008-04-20
• [Presentation] Dendritic Cel ls Contributes to Autoimmune Kidney Injury in MRL-Faslpr Mice. (2007)
  • Author(s): Yasunori Iwata, et. al.
  • Organizer: American Socity of Nephrology 2007
  • Place of Presentation: サンフランシスコ
  • Year and Date: 2007-11-02
• [Presentation] Dendritic Cells Contributes to Autoimmune Kidney Injury in MRL-Faslpr Mice. (2007)
  • Author(s): Yasunori Iwata, et. al.
  • Organizer: American Socity of Nephrology 2007
  • Place of Presentation: サンフランシスコ
  • Year and Date: 2007-11-02
• [Presentation] p38 MAPKを介したCD11c陽性細胞の関与-自己免疫性マウス腎炎モデルを用いた検討- (2007)
  • Author(s): 岩田恭宜, 他
  • Organizer: 第35回日本臨床免疫学会総会
  • Place of Presentation: ホテル阪急エキスポパーク
  • Year and Date: 2007-10-20
• [Presentation] p38 MAPKを介したCD11c陽性細胞の関与-自己免疫性マウス腎炎モデルを用いた検討- (2007)
  • Author(s): 岩田 恭宜, 他
  • Organizer: 第35回 日本臨床免疫学会総会
  • Place of Presentation: ホテル阪急エキスポパーク
  • Year and Date: 2007-10-20
• [Presentation] マウスループス腎炎モデルにおけるp38 MAPKの樹状細胞への関与 (2007)
  • Author(s): 岩田恭宜, 他
  • Organizer: 第51回日本リウマチ学会総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-04-28
• [Presentation] マウスループス腎炎モデルにおけるp38 MAPKの樹状細胞への関与 (2007)
  • Author(s): 岩田 恭宜, 他
  • Organizer: 第51回 リウマチ学会総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-04-28
• [Book] 内科診療実践マニュアル (2009)
  • Author(s): 岩田恭宜、和田隆志
  • Publisher: 日本医学出版(印刷中)
• [Book] 内科診療実践マニュアル, 腎不全
  • Author(s): 岩田恭宜、和田隆志
  • Publisher: 日本医学出版(印刷中)