Role of CTGF in renal diseases in conditional knockout mice
Project/Area Number |
19790581
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Kidney internal medicine
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Research Institution | Kyoto University |
Principal Investigator |
YOKOI Hideki Kyoto University, 医学研究科・産学官連携, 助教 (90378779)
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Project Period (FY) |
2007 – 2008
|
Project Status |
Completed (Fiscal Year 2008)
|
Budget Amount *help |
¥3,630,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥2,200,000 (Direct Cost: ¥2,200,000)
|
Keywords | 腎臓学 / CTGF / CreERT2 / コンディショナルノックアウトマウス / タモキシフェン / Cre リコンビナーゼ / 腎臓 / 糖尿病性腎症 / ポドサイト / CreER^<T2> / ネフリン / loxP / FRT / Rosa26Rマウス |
Research Abstract |
CTGFコンディショナルノックアウトマウスの作製を行った。Targetingコンストラクト、組み換えES細胞、キメラマウスを作製しhomozygous floxed CTGFマウスを確認した。Heterozygous floxed CTGFマウスと全身性の誘導性Creマウスとの交配により得られた変異マウスは、tamoxifenにより組み換えが起こることを確認した。さらにtamoxifenによる誘導型糸球体上皮細胞特異的CreERT2マウスを作製し、薬剤誘導性に上皮細胞特異的に組み換えが認められた。
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Report
(3 results)
Research Products
(17 results)
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[Journal Article] Urinary neutrophil gelatinase-associated lipocalin levels reflect damage in glomeruli, proximal and distal nephrons.2009
Author(s)
Kuwabara T, Mori K, Mukoyama M, Kasahara M, Yokoi H, Saito Y, Yoshioka T, Ogawa Y, Imamaki H, Kusakabe T, Ebihara K, Omata M, Satoh N, Sugawara A, Barasch J, Nakao K.
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Journal Title
Kidney Int 75
Pages: 285-294
Related Report
Peer Reviewed
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[Journal Article] Overexpression of connective tissue growth factor worsens diabetic nephropathy in mice.2008
Author(s)
Yokoi H, Mukoyama M, Mori K, Kasahara M, Suganami T, Sawai K, Yoshioka T, Saito Y, Ogawa Y, Kuwabara T, Sugawara A, Nakao K.
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Journal Title
Kidney Int 73
Pages: 446-455
Related Report
Peer Reviewed
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[Journal Article] Adrenomedullin inhibits connective tissue growth factor expression, extracellular signal-regulated kinase activation and renal fibrosis.2008
Author(s)
Nagae T, Mori K, Mukoyama M, Kasahara M, Yokoi H, Suganami T, Sawai K, Yoshioka T, Koshikawa M, Saito Y, Ogawa Y, Kuwabra T, Tanaka I, Sugawara A, Kuwahara T, Nakao K.
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Journal Title
Kidney Int 74
Pages: 70-80
Related Report
Peer Reviewed
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[Journal Article] Expression of CCN1(CYR61) in developing, normal, and diseased human kidney.2007
Author(s)
Sawai K, Mukoyama M, Mori K, Kasahara M, Koshikawa M, Yokoi H, Yoshioka T, Ogawa Y, Sugawara A, Nishiyama H, Yamada S, Kuwahara T. Saleem MA, Shiota K, Ogawa O, Miyazato M, Kangawa K, Nakao K.
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Journal Title
Related Report
Peer Reviewed
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