Research for novel podocyte-protective and podocyte-destructive factors for development of glomerular regeneration therapy

• Project/Area Number: 19790597
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Kidney internal medicine
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: SAWAI Kazutomo National Cardiovascular Center Research Institute, 生化学部, 特任研究員 (80393213)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,690,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥2,000,000 (Direct Cost: ¥2,000,000)
• Keywords: 腎臓学 / podocyte / 糸球体足細胞 / ネフローゼ症候群 / 巣状糸球体硬化症 / 単状糸球体硬化症 / 単状糸球体硬化症因子 / LDLアフェレーシス / 巣状糸球体硬化症因子 / 腎保護因子

Research Abstract

人工腎臓(透析)治療中の末期腎不全患者は国内で27万人を突破し、その右肩上がりの増加にもかかわらず腎臓病の根本的治療法は存在しない。これは腎臓病特異的な傷害機序が十分に解明されていないことに起因するが、特に腎臓の血液濾過装置を構成する糸球体足細胞(podocyte)の傷害は新しい腎臓特異的な治療標的として注目されている。そこで足細胞に焦点を絞り「足細胞傷害因子」および「足細胞保護因子」の探索を行い、候補因子の同定に成功した。

Research Products

• [Journal Article] Adrenomedullin inhibits connective tissue growth factor expression, extracellular signal-regulated kinase activation and renal fibrosis. (2008)
  • Author(s): Nagae T, Mori K, Mukoyama M, Kasahara M, Yokoi H, Suganami T, Sawai K, Yoshioka T, Koshikawa M, Saito Y, Ogawa Y, Kuwabara T, Tanaka I, Sugawara A, Kuwahara T, Nakao K
  • Journal Title: Kidney Int 74 Pages: 70-80
  • Peer Reviewed
• [Journal Article] Overexpression of connective tissue growth factor in podocytes worsens diabetic nephropathy in mice. (2008)
  • Author(s): Yokoi H, Mukoyama M, Mori K, Kasahara M, Suganami T, Sawai K, Yoshioka T, Saito Y, Ogawa Y, Kuwabara T, Sugawara A, Nakao K
  • Journal Title: Kidney Int 73 Pages: 446-455
  • Peer Reviewed
• [Journal Article] Adrenomedullin inhibits connective tissue growth factor expression, extracellular signal-regulated kinase activation and renal fibrosis. (2008)
  • Author(s): Nagae T, et al.
  • Journal Title: Kidney International 74 Pages: 70-80
  • Peer Reviewed
• [Journal Article] Overexpression of connective tissue growth factor in podocytes worsens diabetic nephropathy in mice. (2008)
  • Author(s): Yokoi H, et al.
  • Journal Title: Kidney International 73 Pages: 446-455
  • Peer Reviewed
• [Journal Article] Overexpression of connective tissue growth factor in podocytes worsens diabetic nephropathy in mice (2008)
  • Author(s): Yokoi H, Mukoyama M, Mori K, Kasahara M, Suganami T, Sawai K, et. al.
  • Journal Title: Kidney International 73・4 Pages: 446-455
  • Peer Reviewed
• [Journal Article] Expression of CCN1 (CYR61) in developing, normal, and diseased human kidney. (2007)
  • Author(s): Sawai K, Mukoyama M, Mori K, Kasahara M, Koshikawa M, Yokoi H, Yoshioka T, Ogawa Y, Sugawara A, Nishiyama H, Yamada S, Kuwahara T, Saleem MA, Shiota K, Ogawa O, Miyazato M, Kangawa K, Nakao K
  • Journal Title: Am J Physiol Renal Physiol 293
  • Peer Reviewed
• [Journal Article] Expression of CCN1(CYR61)in developing,normal,and diseased human kidney (2007)
  • Author(s): Kazutomo Sawai., et. al.
  • Journal Title: American Journal of Physiology, Renal Physiology 293・4
  • Peer Reviewed
• [Presentation] 培養ヒト足細胞を用いたFSGS因子の探索 (2008)
  • Author(s): 澤井一智、宮里幹也、Moin Saleen、寒川賢治
  • Organizer: 第53回日本透析医学会学術集会・総会
  • Place of Presentation: 神戸
  • Year and Date: 2008-06-20
• [Presentation] 培養ヒトpodocyteを用いた巣状糸球体硬化症の原因因子の探索 (2008)
  • Author(s): 澤井一智、宮里幹也、Moin Saleen、寒川賢治
  • Organizer: 第51回日本腎臓学会学術総会
  • Place of Presentation: 福岡
  • Year and Date: 2008-05-30