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Clinicopathohogical study of the immunopathological roles of the anti-Aquaporin4 antibody in multiple sclerosis.

Research Project

Project/Area Number 19790599
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Neurology
Research InstitutionTohoku University

Principal Investigator

MISU Tatsuro  Tohoku University, 大学院・医学研究科, 助教 (00396491)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,630,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥2,200,000 (Direct Cost: ¥2,200,000)
Keywords多発性硬化症 / アクアポリン4 / 視神経脊髄炎 / アストロサイト / ウォーターチャンネル / 神経病理 / 神経免疫 / 炎症性疾患 / 中枢神経系
Research Abstract

19世紀半ばに多発性硬化症(MS)の概念が発表されて以来、視神経脊髄炎(NMO)はMSとの異同が不明であったが、脱髄疾患であるMSとは異なりアクアポリン4抗体によるアストロサイト障害を起因として生じる疾患である事を解明し、NMOにおける脱髄は二次的であることを報告した。その成果は国際誌Brainに相次いで掲載し国際学会にて発表するとともに、AQP4抗体の病原性を知る手掛かりを得て国内外から高い評価を得た。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (50 results)

All 2008 2007 Other

All Journal Article (23 results) (of which Peer Reviewed: 8 results) Presentation (21 results) Book (2 results) Remarks (4 results)

  • [Journal Article] A prominent elevation of glial fibrillary acidic protein in the cerebrospinal fluid during relapse in neuromyelitis optica.2008

    • Author(s)
      Takano R, Misu T, Takahashi T, Izumiyama M, Fujihara K, Itoyama Y.
    • Journal Title

      Tohoku J Exp Med 215

      Pages: 55-59

    • NAID

      10024167900

    • Related Report
      2008 Final Research Report
  • [Journal Article] Intractablc hiccup and nausea in neuromyelitis optica with anti-aquaporin4 antibody: a herald of acute exacerbations.2008

    • Author(s)
      Takahashi T, Miyazawa I, Misu T, Takano R, Nakashima I, Fujihara K, Tobita M, Itoyama Y.
    • Journal Title

      J Neurol Neurosurg Psychiatry 79

      Pages: 1075-8

    • Related Report
      2008 Final Research Report
  • [Journal Article] Development of extensive brain lesions following interferon beta therapy in relapsing neuromyelitis optica and longitudinally extensive myelitis.2008

    • Author(s)
      Shimizu Y, Yokoyama K, Misu T, Takahashi T, Fujihara K, Kikuchi S, Itoyama Y, Iwata M.
    • Journal Title

      J Neurol 255

      Pages: 305-307

    • Related Report
      2008 Final Research Report
  • [Journal Article] Preferential spinal central gray matter involvement in neuromyelitis optica. An MRI study.2008

    • Author(s)
      Nakamura M, Miyazawa I, Fujihara K, Nakashima I, Misu T, Watanabe S, Takahashi T, Itoyama Y.
    • Journal Title

      J Neurol 255

      Pages: 163-170

    • Related Report
      2008 Final Research Report
  • [Journal Article] 視神経脊髄炎(NMO)とアクアポリン4抗体2008

    • Author(s)
      三須建郎、藤原一男、糸山泰人
    • Journal Title

      BRAIN and NERVE 60(5)

      Pages: 527-537

    • NAID

      40016064922

    • Related Report
      2008 Final Research Report
  • [Journal Article] アクアポリン4抗体と視神経脊髄炎(NMO)2008

    • Author(s)
      藤原一男、三須建郎、高橋利幸、中島一郎、糸山泰人
    • Journal Title

      神経内科 69(4)

      Pages: 367-371

    • Related Report
      2008 Final Research Report
  • [Journal Article] NMOの診断と病態におけるアクアポリン4抗体の意義2008

    • Author(s)
      藤原一男、三須建郎、高橋利幸、中島一郎、中村正史、佐藤滋、糸山泰人
    • Journal Title

      Neuroimmunol 16(2)

      Pages: 155-159

    • Related Report
      2008 Final Research Report
  • [Journal Article]2008

    • Author(s)
      藤原一男、中島一郎、三須建郎、高橋利幸、渡辺承平、中村正史、佐藤滋、糸山泰人
    • Journal Title

      神経治療学 25(6)

      Pages: 701-706

    • Related Report
      2008 Final Research Report
  • [Journal Article] 視神経脊髄炎とアクアポリン4抗体〜アストログリア病との出会い(日本神経免疫学会賞)2008

    • Author(s)
      三須建郎
    • Journal Title

      東北医学雑誌 120

      Pages: 58-61

    • Related Report
      2008 Final Research Report
  • [Journal Article] NMOとアクアポリン4抗体の病理学的意義-アストロサイトに注目して2008

    • Author(s)
      三須建郎、藤原一男、糸山泰人
    • Journal Title

      Clinical Neuroscience 26

      Pages: 770-773

    • Related Report
      2008 Final Research Report
  • [Journal Article] 多発性硬化症におけるrituximabを用いたB細胞標的療法の有効性2008

    • Author(s)
      三須建郎
    • Journal Title

      内科 102(5)

      Pages: 1023-1025

    • NAID

      40016306962

    • Related Report
      2008 Final Research Report
  • [Journal Article] Intractable hiccup and nausea in neuromyelitis optica with anti-aquapor in-4 antibody : a herald of acute exacerbation2008

    • Author(s)
      Takahashi T, et.al.
    • Journal Title

      J Neurol Neurosurg Psychiatry 79

      Pages: 1075-1078

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A prominent elevation of glial fibrillary acidic protein in the cerebrospin al fluid during relapse in neuromyelitis optica2008

    • Author(s)
      Takano R, et.al.
    • Journal Title

      Tohoku J Exp Med 215

      Pages: 55-59

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuromyelitis optica and anti-aquaporin 4 antibody-an overview2008

    • Author(s)
      Misu T, et.al.
    • Journal Title

      Brain Nerve 60

      Pages: 527-537

    • NAID

      40016064922

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Preferential spinal central gray matter involvement in neuromyelitis optica. An MRI study2008

    • Author(s)
      Nakamura M, et. al.
    • Journal Title

      J Neurol 255

      Pages: 163-70

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of extensive brain lesions following interferon bate therapy in relapsing neuromyelitis optica and longitudinally extensive myelitis2008

    • Author(s)
      Shimizu Y, et. al.
    • Journal Title

      J Neurol 255

      Pages: 305-7

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Low-dose coriticosteroids reduce relapse in neuromyelitis optica: a retrospective analysis.2007

    • Author(s)
      Watanabe S, Misu T, et al.
    • Journal Title

      Mult Scler 13

      Pages: 968-74

    • Related Report
      2008 Final Research Report
  • [Journal Article] Anti-aquaporin-4 antibody is involved in the pathogenesis of NMO: a study on antibody titre.2007

    • Author(s)
      Takahashi T, Fujihara K, Nakashima I, Misu T, et al.
    • Journal Title

      Brain 130

      Pages: 1235-43

    • Related Report
      2008 Final Research Report
  • [Journal Article] Loss of aquaporin 4 in lesions of neuromyelitis optica: distinction from multiple selerosis.2007

    • Author(s)
      Misu T, Fujihara K, et al.
    • Journal Title

      Brain 130

      Pages: 1224-34

    • Related Report
      2008 Final Research Report
  • [Journal Article] Modulation of dendritic cell development by immunoglobulin G in control subjects and multiple sclerosis patients2007

    • Author(s)
      Ohkuma K, et. al.
    • Journal Title

      Clin Exp Immunol 150

      Pages: 397-406

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Low-dose corticosteroids reduce relapses in neuromyelitis optica: a retrospective analysis2007

    • Author(s)
      Watanabe, et. al.
    • Journal Title

      Mult Scler 13

      Pages: 968-74

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-aquaporin4 antibody is involved in the pathogenesis of NMO: a study on antibody titre2007

    • Author(s)
      Takahashi T, et. al.
    • Journal Title

      Brain 130

      Pages: 1235-43

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Loss of aquaporin 4 in lesions of neuromyelitis optica: distinction from multiple sclerosis2007

    • Author(s)
      Misu T, et. al.
    • Journal Title

      Brain 130

      Pages: 1224-34

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 視神経脊髄炎における抗アクアポリン4抗体の病理学的意義-続報2008

    • Author(s)
      三須建郎
    • Organizer
      第13回グリア研究会
    • Place of Presentation
      東京
    • Year and Date
      2008-11-08
    • Related Report
      2008 Final Research Report
  • [Presentation] 抗アクアポリン4抗体の病理学的意義〜その研究の進歩2008

    • Author(s)
      三須建郎
    • Organizer
      第3回川棚神経科学の会
    • Place of Presentation
      長崎県川棚
    • Year and Date
      2008-11-07
    • Related Report
      2008 Final Research Report
  • [Presentation] Heterogeneity vs Homogeneity〜MS pathology review up-to-date2008

    • Author(s)
      三須建郎
    • Organizer
      第7回MSワークショップ
    • Place of Presentation
      大阪
    • Year and Date
      2008-08-03
    • Related Report
      2008 Final Research Report
  • [Presentation] NMOの病理とアクアポリン4自己免疫の実験モデル2008

    • Author(s)
      三須建郎
    • Organizer
      第7回MSワークショップ
    • Place of Presentation
      大阪
    • Year and Date
      2008-08-02
    • Related Report
      2008 Final Research Report
  • [Presentation] Neuromyelitis opticaの病巣におけるAquapo4inrの欠落とアストロサイト障害の関連:MSとの相違2008

    • Author(s)
      三須建郎、藤原一男、柿田明美、今野秀彦、高橋均、糸山泰人
    • Organizer
      第49回日本神経病理学会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-21
    • Related Report
      2008 Final Research Report
  • [Presentation] Neuromyelitis opticaの病巣におけるAquaporin4の欠落とアストロサイト障害の関連 : MSとの相違2008

    • Author(s)
      三須建郎
    • Organizer
      第49回日本神経病理学会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] Neuromyelitis opticaの病巣におけるアストロサイト障害の検討2008

    • Author(s)
      三須建郎、藤原一男、高野里奈、高橋利幸、柿田明美、高橋均、糸山泰人
    • Organizer
      第49回日本神経学会
    • Place of Presentation
      横浜
    • Year and Date
      2008-05-16
    • Related Report
      2008 Final Research Report
  • [Presentation] Markcd increase of CSF GFAP in neuromyelitis optica-an astrocytic damage marker.2008

    • Author(s)
      Misu T, Takano R, Fujihara K, Takahashi T, Sato S, Itoyama Y.
    • Organizer
      1st Pan-Asian Committee of Treatment and Research in Multiple Sclerosis (PACTRIMS2008)
    • Place of Presentation
      Malasia
    • Related Report
      2008 Final Research Report
  • [Presentation] Immunopathology of MS and Implications for Classification: Differences in MS and NMO.2007

    • Author(s)
      Misu T
    • Organizer
      5th Pan Asian MS Forum Conference.
    • Place of Presentation
      台湾
    • Year and Date
      2007-11-02
    • Related Report
      2007 Annual Research Report
  • [Presentation] Loss of Aquaporin 4 in lesions of Neuromyelitis optica: distinction from multiple sclerosis.2007

    • Author(s)
      Misu T, Fujihara K, Kakita A
    • Organizer
      23rd Congress of the European Comittee for Treatment and Research in Multiple Sclerosis.
    • Place of Presentation
      プラハ(チェコ)
    • Year and Date
      2007-10-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] 視神経脊髄炎の病巣におけるアクアポリン4の欠落:多発性硬化症との相違 アストロサイトの意義に注目して.2007

    • Author(s)
      三須建郎
    • Organizer
      正常圧水頭症と関連疾患の病因・病態と治療に関する研究(厚生労働科学難治性疾患克服研究事業(H17-難治-一般017).
    • Place of Presentation
      千葉
    • Year and Date
      2007-09-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] Loss of Aquaporin 4 in lesions of Neuromyelitis optica: distinction from multiple sclerosis.2007

    • Author(s)
      Misu T, Fujihara K, Kakita A
    • Organizer
      The 6th MS Workshop in Sapporo.
    • Place of Presentation
      札幌
    • Year and Date
      2007-08-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] Loss of Aquaporin 4 in lesions of Neuromyelitis optica: distinction from multiple sclerosis.2007

    • Author(s)
      Misu T, Fujihara K, Kakita A, et. al.
    • Organizer
      第5回アクアポリン国際会議.
    • Place of Presentation
      奈良
    • Year and Date
      2007-07-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] Loss of Aquaporin 4 in lesions of Neuromyelitis optica: distinction from multiple sclerosis.2007

    • Author(s)
      三須建郎
    • Organizer
      MSカンファレンス.
    • Place of Presentation
      仙台
    • Year and Date
      2007-06-19
    • Related Report
      2007 Annual Research Report
  • [Presentation] 視神経脊髄炎の病巣におけるアクアポリン4の欠落:多発性硬化症との相違.2007

    • Author(s)
      三須建郎
    • Organizer
      東北臨床超微形態懇話会.
    • Place of Presentation
      仙台
    • Year and Date
      2007-06-06
    • Related Report
      2007 Annual Research Report
  • [Presentation] Loss of Aquaporin 4 in lesions of Neuromyelitis optica: distinction from multiple sclerosis.2007

    • Author(s)
      Misu T, Fujihara K, Kakita A, et. al.
    • Organizer
      59th Annual meeting of the American Academy of Neurology.
    • Place of Presentation
      ボスント(アメリカ)
    • Year and Date
      2007-05-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] Loss of Aquaporin 4 in lesions of Neuromyelitis optica: distinction from multiple sclerosis.2007

    • Author(s)
      Misu T, Fujihara K, Kakita A, et. al.
    • Organizer
      平成19年度生理学研究所研究会『グリア細胞による脳機能調節機構の解明 新しいグリアの手がかりを求めて』.
    • Place of Presentation
      名古屋(生理学研究所)
    • Year and Date
      2007-04-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] Neuromyelitis opticaの脊髄病巣におけるアクアポリン4の欠落.2007

    • Author(s)
      三須建郎、藤原一男、柿田明美, 他
    • Organizer
      第48回日本神経学会総会.
    • Place of Presentation
      名古屋
    • Year and Date
      2007-04-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] 抗アクアポリン4抗体とNMO-IgGの比較検討.2007

    • Author(s)
      高橋利幸、中村正史, 三須建郎, 他
    • Organizer
      日本神経免疫学会
    • Place of Presentation
      金沢
    • Year and Date
      2007-04-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] 視神経脊髄炎(NMO)の病理学的検討〜アクアポリン4、アストログリアを起因とする疾患2007

    • Author(s)
      三須建郎、藤原一男、柿田明美, 他
    • Organizer
      日本神経免疫学会
    • Place of Presentation
      金沢
    • Year and Date
      2007-04-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] 視神経脊髄炎における低用量連日プレドニゾロン投与の再発抑制効果.2007

    • Author(s)
      渡部承平, 三須建郎, 宮澤イザベル, 他
    • Organizer
      日本神経免疫学会
    • Place of Presentation
      金沢
    • Year and Date
      2007-04-12
    • Related Report
      2007 Annual Research Report
  • [Book] I.多発性硬化症の特殊型と類縁疾患 (2)Neuro myelitis optica(NMO)とアクアポリン4抗体. 多発性硬化症の診断と治療2008

    • Author(s)
      三須建郎、藤原一男、糸山泰人
    • Publisher
      新興医学出版社
    • Related Report
      2008 Final Research Report
  • [Book] 多発性硬化症の診断と治療2008

    • Author(s)
      三須建郎
    • Total Pages
      285
    • Publisher
      新興医学出版社
    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://neurol.med.tohoku.ac.jp/index.html

    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://www.ms.med.tohoku.ac.jp/index.html

    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://neural.med.tohoku.ac.jp/inckex.html

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.ins.med.tohoku.ac.jp/index.html

    • Related Report
      2008 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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