Establishment of effective therapy for neuropathic pain based on axonal ionic pathophysiology

• Project/Area Number: 19790600
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Neurology
• Research Institution: Chiba University
• Principal Investigator: MISAWA Sonoko Chiba University, 大学院医学研究院, 助教 (30375753)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,560,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2007: ¥2,000,000 (Direct Cost: ¥2,000,000)
• Keywords: 臨床神経生理学 / 生理学 / 神経科学 / 糖尿病 / 神経原性疼痛

Research Abstract

神経原性疼痛には再生に伴う軸索のNaチャネルの過剰発現による興奮性増大が関係するとされる。軸索イオンチャネル機能を非侵襲的かつリアルタイムに評価できる唯一の手法であるコンピューター制御軸索機能検査法を神経原性慢性疼痛患者の末梢感覚神経に応用し、疼痛の病態機序の一つとして、軸索Na電流の増大があることをヒトで初めて示した。

Research Products

• [Journal Article] Differences in excitability properties of FDI and ADM motor axons. (2009)
  • Author(s): Bae JS, Sawai S, Misawa S, et al.
  • Journal Title: Muscle Nerve. 39 Pages: 350-4
  • Peer Reviewed
• [Journal Article] Utility of trapezius EMG for diagnosis of amyotrophic lateral sclerosis. (2009)
  • Author(s): Sonoo M, Kuwabara S, Shimizu T, Komori T, Hirashima F, Inaba A, Hatanaka Y, Misawa S, Kugio Y, Tokyo Metropolitan Neuromuscular Electrodiagnosis Study Group.
  • Journal Title: Muscle Nerve. 39 Pages: 63-70
  • Peer Reviewed
• [Journal Article] Successful combination treatment with bevacizumab, thalidomide and autologous PBSC for severe POEMS syndrome. (2009)
  • Author(s): Ohwada C, Nakaseko C, Sakai S, Takeda Y, Abe D, Takeuchi M, Sakaida E, Masuda S, Shimizu N, Cho R, Nishimura M, Kanai K, Misawa S, Kuwabara S.
  • Journal Title: Bone Marrow Transplant. (in press)
  • Peer Reviewed
• [Journal Article] Differences in excitability properties of FDI and ADM motor axons (2009)
  • Author(s): Bae JS, Sawai S, Misawa S, Kanai K. Those S. Kuwabara S.
  • Journal Title: Muscle Nerve 39 Pages: 350-4
  • Peer Reviewed
• [Journal Article] Treatment for POEMS (polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes) syndrome (2009)
  • Author(s): Kuwabara S, Dispenzieri A, Arimura K, Misawa S.
  • Journal Title: Cochrane Database Syst Rev
  • Peer Reviewed
• [Journal Article] Neurologic improvement after peripheral blood stem cell transplantation in POEMS syndrome (2009)
  • Author(s): Kuwabara S, Misawa S, et.al.
  • Journal Title: Neurology 71 Pages: 1691-5
  • Peer Reviewed
• [Journal Article] Treatment for POEMS (polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes) syndrome. (2008)
  • Author(s): Kuwabara S, Dispenzieri A, Arimura K, Misawa S.
  • Journal Title: Cochrane Database Syst Rev. 4
  • Peer Reviewed
• [Journal Article] Neurologic improvement after peripheral blood stem cell transplantation in POEMS syndrome. (2008)
  • Author(s): Kuwabara S, Misawa S, Kanai K, Suzuki Y, Kikkawa Y, Sawai S, Hattori T, Nishimura M, Nakaseko C.
  • Journal Title: Neurology. 71 Pages: 1691-5
  • Peer Reviewed
• [Journal Article] Development of Isaacs' syndrome following complete recovery of voltage-gated potassium channel antibody-associated limbic encephalitis. (2008)
  • Author(s): Takahashi H, Mori M, Sekiguchi Y, Misawa S, Sawai S, Hattori T, Kuwabara S.
  • Journal Title: J Neurol. Sci. 275 Pages: 185-7
  • Peer Reviewed
• [Journal Article] Effects of age on excitability properties in human motor axons. (2008)
  • Author(s): Bae JS, Sawai S, Misawa S, Kanai K, Isose S, Shibuya K, Kuwabara S.
  • Journal Title: Clin Neurophysiol. 119 Pages: 2282-6
  • Peer Reviewed
• [Journal Article] Restrictive usage of monoclonal immunoglobulin lambda light chain germline in POEMS syndrome. (2008)
  • Author(s): Abe D, Nakaseko C, Takeuchi M, Tanaka H, Ohwada C, Sakaida E, Takeda Y, Oda K, Ozawa S, Shimizu N, Masuda S, Cho R, Nishimura M, Misawa S, Kuwabara S, Saito Y.
  • Journal Title: Blood. 112 Pages: 836-9
  • Peer Reviewed
• [Journal Article] Peripheral nerve demyelination in multiple sclerosis. (2008)
  • Author(s): Misawa S, Kuwabara S, Mori M, Hayakawa S, Sawai S, Hattori T.
  • Journal Title: Clin Neurophysiol. 119 Pages: 1829-33
  • Peer Reviewed
• [Journal Article] Sympathetic sweat responses and skin vasomotor reflexes in carpal tunnel syndrome. (2008)
  • Author(s): Kuwabara S, Tamura N, Yamanaka Y, Misawa S, Isose S, Bae JS, Hattori T, Asahina M.
  • Journal Title: Clin Neurol Neurosurg. 110 Pages: 691-5
  • Peer Reviewed
• [Journal Article] The ipsilateral cortico-spinal tract is activated after hemiparetic stroke. (2008)
  • Author(s): Misawa S, Kuwabara S, Matsuda S, Honma K, Ono J, Hattori T.
  • Journal Title: Eur J Neurol. 15 Pages: 706-11
  • Peer Reviewed
• [Journal Article] Thalidomide reduces serum VEGF levels and improves peripheral neuropathy in POEMS syndrome. (2008)
  • Author(s): Kuwabara S, Misawa S, Kanai K, Sawai S, Hattori T, Nishimura M, Nakaseko C.
  • Journal Title: J Neurol Neurosurg Psychiatry. 79 Pages: 1255-7
  • Peer Reviewed
• [Journal Article] Changes in excitability properties associated with axonal regeneration in human neuropathy and mouse Wallerian degeneration. (2008)
  • Author(s): Sawai S, Kanai K, Nakata M, Hiraga A, Misawa S, Isose S, Hattori T, Kuwabara S.
  • Journal Title: Clin Neurophysiol. 119 Pages: 1097-105
  • Peer Reviewed
• [Journal Article] Bickerstaff's brainstem encephalitis and Fisher syndrome form a continuous spectrum: clinical analysis of 581 cases. (2008)
  • Author(s): Ito M, Kuwabara S, Odaka M, Misawa S, Koga M, Hirata K, Yuki N.
  • Journal Title: J Neurol. 255 Pages: 674-82
  • Peer Reviewed
• [Journal Article] Dissociated small hand muscle atrophy in amyotrophic lateral sclerosis: frequency, extent, and specificity. (2008)
  • Author(s): Kuwabara S, Sonoo M, Komori T, Shimizu T, Hirashima F, Inaba A, Misawa S, Hatanaka Y; Tokyo Metropolitan Neuromuscular Electrodiagnosis Study Group.
  • Journal Title: Muscle Nerve. 37 Pages: 426-30
  • Peer Reviewed
• [Journal Article] Genetically confirmed Huntington's disease masquerading as motor neuron disease. (2008)
  • Author(s): Kanai K, Kuwabara S, Sawai S, Nakata M, Misawa S, Isose S, Hirano S, Kawaguchi N, Katayama K, Hattori T.
  • Journal Title: Mov Disord. 23 Pages: 748-51
  • Peer Reviewed
• [Journal Article] Pharmacologic intervention in axonal excitability: In vivo assessment of nodal persistent sodium currents in human neuropathies (2008)
  • Author(s): Kuwabara S and Misawa S
  • Journal Title: Current Molecular Pharmacology 1 Pages: 61-67
• [Journal Article] Peripheral nerve demyelination in multiple sclerosis (2008)
  • Author(s): Misawa S, et. al.
  • Journal Title: Clin Neurophysiol (In press)
  • Peer Reviewed
• [Journal Article] The ipsilateral cortico-spinal tract is activated after hemiparetic stroke (2008)
  • Author(s): Misawa S, et. al.
  • Journal Title: Eur J Neurol (In press)
  • Peer Reviewed
• [Journal Article] Anti-GQ1b antibody does not affect neuromuscular transmission in human limb muscle. (2007)
  • Author(s): Kuwabara S, Misawa S, Takahashi H, Sawai S, Kanai K, Nakata M, Mori M, Hattori T, Yuki N.
  • Journal Title: J Neuroimmunol. 189 Pages: 158-62
  • Peer Reviewed
• [Journal Article] Median-radial sensory nerve comparative studies in the detection of median neuropathy at the wrist in diabetic patients. (2007)
  • Author(s): Imada M, Misawa S, Sawai S, Tamura N, Kanai K, Sakurai K, Sakamoto S, Nomura F, Hattori T, Kuwabara S.
  • Journal Title: Clin Neurophysiol. 118 Pages: 1405-9
  • Peer Reviewed
• [Journal Article] Failure of treatment with anti-VEGF monoclonal antibody for long-standing POEMS syndrome. (2007)
  • Author(s): Kanai K, Kuwabara S, Misawa S, Hattori T.
  • Journal Title: Intern Med. 46 Pages: 311-3
  • NAID: 130000078542
  • Peer Reviewed
• [Journal Article] Is excitation-contraction coupling impaired in myasthenia gravis? (2007)
  • Author(s): Nakata M, Kuwabara S, Kawaguchi N, Takahashi H, Misawa S, Kanai K, Tamura N, Sawai S, Motomura M, Shiraishi H, Takamori M, Maruta T, Yoshikawa H, Hattori T.
  • Journal Title: Clin Neurophysiol. 118 Pages: 1144-8
  • Peer Reviewed
• [Journal Article] Time course of axonal regeneration in acute motor axonal neuropathy. (2007)
  • Author(s): Tamura N, Kuwabara S, Misawa S, Kanai K, Nakata M, Sawai S, Mori M, Hattori T.
  • Journal Title: Muscle Nerve. 35 Pages: 793-5
  • Peer Reviewed
• [Journal Article] Anti-MuSK-positive myasthenia gravis: neuromuscular transmission failure in facial and limb muscles. (2007)
  • Author(s): Kuwabara S, Nemoto Y, Misawa S, Takahashi H, Kawaguchi N, Hattori T.
  • Journal Title: Acta Neurol Scand. 115 Pages: 126-8
  • Peer Reviewed
• [Presentation] 軸索イオンチャネル機能モニタリングに基づく糖尿病性末梢神経障害治療 (2008)
  • Author(s): 三澤園子
  • Organizer: 第38回臨床神経生理学会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2008-11-12
• [Presentation] 筋萎縮性側索硬化症における解離性小手筋萎縮:CMAP 振幅による定量的検討 (2008)
  • Author(s): 三澤園子ほか.
  • Organizer: 第38回日本臨床神経生理学会学術集会
  • Place of Presentation: 神戸
• [Presentation] 慢性炎症性脱髄性多発ニューロパチーの臨床病型と治療反応性 (2008)
  • Author(s): 三澤園子ほか.
  • Organizer: 第19回日本末梢神経障害学会学術集会
  • Place of Presentation: 名古屋
• [Presentation] 脳性麻痺の頚部ジストニアによる頚椎症周術期管理におけるボツリヌス治療 (2008)
  • Author(s): 三澤園子ほか.
  • Organizer: 第26回神経治療学会
  • Place of Presentation: 横浜
• [Presentation] クロウ・フカセ症候群における新規治療展望:サリドマイド療法 (2008)
  • Author(s): 三澤園子ほか.
  • Organizer: 第49回日本神経学会総会
  • Place of Presentation: 横浜
• [Presentation] 慢性炎症性脱髄性多発ニューロパチーの臨床的電気生理学的病型と治療反応性 (2008)
  • Author(s): 三澤園子ほか.
  • Organizer: 第20回日本神経免疫学会学術集会
  • Place of Presentation: 新潟
• [Presentation] 教育講演:糖尿病性ニューロパチーにおけるイオンチャネルの病態 (2007)
  • Author(s): 三澤 園子
  • Organizer: 第37回臨床神経生理学会
  • Place of Presentation: 栃木県総合文化センター
  • Year and Date: 2007-11-21