| Budget Amount *help |
¥4,298,160 (Direct Cost: ¥3,629,354、Indirect Cost: ¥668,806)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥558,160 (Direct Cost: ¥429,354、Indirect Cost: ¥128,806)
Fiscal Year 2007: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Research Abstract |
We previously discovered that the glycosylation of three glycoproteins were altered in Alzheimer's disease (AD). In this study, we identified all glycoproteins, established the methods to quantify the sugars of each glycoproteins and measured glycosylation of them. Identified serum transferrin and immune system associated protein had altered quantities of several kinds of sugar in AD patients compared with non-demented control (NDC) groups. Sialic acid in Alzheimer's serum transferrin also changed in early stage of AD, which suggests the sialic acid of transferrin is an available serum diagnostic marker of AD. Immune system associated protein had altered sugars compared with not only NDC groups but also non-AD dementia groups, and correlated with cerebrospinal fluid amyloid β(Aβ). This glycoprotein is expected to be an efficient serum marker which can monitor the changes of Aβ in the brain.
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